Results 61 to 70 of about 6,653 (173)

New Advances in Biologic Treatment for Malignant Atrophic Papulosis: A Systematic Review

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Malignant atrophic papulosis (MAP) is the systemic subtype of Degos disease, characterized by high lethality. Currently there is no standardized treatment protocol. Steroids and immunosuppressive therapies result in limited effectiveness. Biologic treatments offer promising therapeutic potential for MAP and significantly improve prognosis ...
Jia-Wei Liu, Xiao Ma, Dong-Lai Ma, Zhirong Yao   +3 more
wiley   +1 more source

Epidemiology of Leech Infestation in Livestock and Evaluation of Phytolacca dodecanda (Endod) for Aquatic Leech Control in Selected Districts of South, Central, and North Gondar Zones, Northwest Ethiopia

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
The livestock industry in Ethiopia suffers greatly from parasites and parasitic diseases including leech infestation. Leech infestation is a serious disease of animals and occasionally humans, but it is usually ignored. A cross‐sectional study design was carried out from January 2022 to June 2022 to estimate the prevalence of leech infestation in ...
Moges Maru, Abrham Ayele Tsegaye, Zewdu Seyoum Tarekegn, Gashaw Getaneh Dagnaw, Seleshe Nigatu, Abibo Wondie, Elias Kebede, Tigist Kindie, Abiy Maru Alemayehu, Nega Yismaw Alemu, Shimelis Dagnachew, Sumanta Nandi   +11 more
wiley   +1 more source

Hirudin in the Treatment of Chronic Kidney Disease

Molecules
Chronic kidney disease (CKD) is a common public health concern. The global burden of CKD is increasing due to the high morbidity and mortality associated with it, indicating the shortcomings of therapeutic drugs at present.
Sai-Ji Liu, Yi-Ling Cao, Chun Zhang
doaj   +1 more source

Research progress on the treatment of diabetic nephropathy with leech and its active ingredients

Frontiers in Endocrinology
Diabetic nephropathy (DN) is a major microvascular complication of diabetes and a common cause of chronic kidney disease. There is currently a lack of effective treatments for DN, and the prognosis for patients remains poor.
Feng Tian, Xiang Yi, Feifei Yang, Yao Chen, Wenhui Zhu, Peng Liu, Shuju Li   +6 more
doaj   +1 more source

The Antithrombotic Effect of Recombinant Neorudin on Thrombi

Drug Design, Development and Therapy, 2022
Yu-Bin Liu,1 Lin Zhang,1 Xing-Chen Zhou,1 Ying Zhou,1 Yun Liu,1 Can Zheng,1 Xiao Xu,1 Pan-Pan Geng,1 Chun-Hua Hao,2 Zhuan-You Zhao,2 Chu-Tse Wu,1 Ji-De Jin1 1Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine,
Liu YB, Zhang L, Zhou XC, Zhou Y, Liu Y, Zheng C, Xu X, Geng PP, Hao CH, Zhao ZY, Wu CT, Jin JD   +11 more
doaj  

Jalaukāvacaraṇa (Hirudo therapy) in the management of necrosed index finger due to crush injury

Ancient Science of Life, 2018
Necrosis of tissue has become the challenging case, considering the difficulties of its management to bring back the normalcy of dead tissue. Treatment choice in surgery ends up with amputation of the affected part which leads to depression to a patient.
Dudhamal Tukaram Sambhaji, Komang Sudarmi   +1 more
doaj   +1 more source

Donepezil Combined with Natural Hirudin Improves the Clinical Symptoms of Patients with Mild-to-Moderate Alzheimer's Disease: A 20-Week Open-Label Pilot Study

International Journal of Medical Sciences, 2012
Aim: To evaluate the efficacy and safety of donepezil plus natural hirudin in patients with mild-to-moderate Alzheimer's Disease. Methods: In the 20-week, randomized, open-label and controlled study, 84 patients received either donepezil (5 mg/day for ...
De-qiang Li, Yu-ping Zhou, Han Yang
doaj  

Protective Effect and Molecular Mechanism of Hirudin on Kidney of Diabetic Rats

Xiehe Yixue Zazhi
Objective To investigate the protective effect of hirudin on kidneys of diabetic rats and its molecular mechanism. Methods Eighteen Sprague-Dawley rats were randomly divided into control group (n=5) and model group (n=13).
HE Yiqian, XIE Jun, ZHAO Bingjia, LIANG Xiaochun, QU Ling   +4 more
doaj   +1 more source

The Properties of Scrambled Hirudins

Journal of Biological Chemistry, 1995
Scrambled hirudins serve as relevant folding intermediates during in vitro renaturation of the reduced/denatured hirudin. Eleven species of scrambled hirudins were isolated and structurally identified. Their properties, including their relative stability and the kinetics of their consolidation (disulfide reshuffling) to attain the native structure ...
openaire   +2 more sources

Construction of hydrogen peroxide-scavenging liposomes based on vitamin E and evaluation of its in vitro anticoagulant effect

陆军军医大学学报
Objective To construct vitamin E (tocopherol, VE)-based liposomes with both hydrogen peroxide-scavenging function and anticoagulant effect, and explore whether they can be used to treat acute ischemic stroke and then evaluate their in vitro anticoagulant
YANG Qinghua, ZHANG Jianxiang, ZHOU Zhenhua   +2 more
doaj   +1 more source