Results 51 to 60 of about 7,899 (213)
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Post‐burn auricular defects compromise both aesthetics and facial symmetry, often imposing significant social and psychological burdens that severely diminish patients' quality of life. Scarring in the mastoid region following burns typically exhibits poor elasticity and texture, along with compromised cutaneous blood supply.
Siming Wei, Yongjun Chen, Liwei Dong
wiley +1 more source
Leech therapy in the treatment of a penile haematoma in a stallion
Veterinární Medicína, 2021 Treatment of penile haematomas includes conventional therapy and/or surgical intervention which may not always result in the recovery of all penile functions.
A Nowicki, J Jaworska, W Baranski
doaj +1 more source
Pharmacokinetics of recombinant hirudin in healthy horses
, 2004 REASONS FOR PERFORMING STUDY: Recombinant (r)-hirudin is a specific inhibitor of thrombin that is independent of the activity of antithrombin. OBJECTIVES: To evaluate pharmacokinetic properties and coagulatory changes of r-hirudin in healthy horses ...
Wunderli-Allenspach, H +5 more
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British Journal of Haematology, Volume 208, Issue 6, Page 1965-1979, June 2026.Summary ETV6‐related thrombocytopenia (ETV6‐RT) is an inherited platelet disorder caused by germline ETV6 variants. Despite recent progress, the mechanisms underlying platelet dysfunction in ETV6‐RT remain unclear. We investigated 12 patients from six families using functional assays, electron microscopy, quantitative proteomics and cytoskeletal ...
Ivan P. Tesakov +15 more
wiley +1 more source
Effects of Recombinant Hirudin (r-Hirudin, HBW 023) on Coagulation and Platelet Activation In Vivo
, 1995 In a double-blind, randomized, crossover study, we investigated in 15 healthy male volunteers the effects of recombinant (r-) hirudin (HBW 023, 0.35 mg/kg body wt SC), unfractionated heparin (UFH, HeparinNovo; 150 IU/kg body wt SC), and a low-molecular ...
Hans-Georg Eichler +7 more
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Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT CYP2C19 genetic polymorphisms impact the antiplatelet effect of clopidogrel and associate with ischemic and bleeding risk in patients undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the association of CYP2C19 and platelet reactivity (PR) with these risks, in atrial fibrillation (AF) patients undergoing PCI ...
Diona Gjermeni +12 more
wiley +1 more source
Sulphation of hirudin in BHK cells
, 1990 Hirudin, a thrombin inhibitor of the leech, was expressed in BHK cells; the alpha 1-antitrypsin signal peptide was used to direct secretion into the culture medium.
Bischoff, Rainer; id_orcid +7 more
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Journal of Pharmacopuncture, 2004 Objective : This experimental studies were performed in order to prove the effect of Hirudin Herbal-acupuncture by using rats that had neuronal damage due to the Middle Cerebral Artery Occulsion(MCAO).
Suk Jae-Wook +4 more
doaj +1 more source
Diabetes and Delayed Wound Healing: Molecular Mechanisms and Dermatological Interventions
International Wound Journal, Volume 23, Issue 6, June 2026.ABSTRACT Diabetes mellitus is a global burden that affects wound healing at nearly every stage, transforming what should be a coordinated and self‐limited repair process into a chronic, non‐healing state. In diabetic patients, sustained hyperglycemia drives persistent inflammation, impaired angiogenesis, fibroblast dysfunction and extracellular matrix ...
Sasha Jreije +4 more
wiley +1 more source
Production of disulfide-linked hirudin dimer by in vitro folding
, 1993 A simple process of in vitro folding has been developed for the preparation of hirudin dimer. A variant of recombinant hirudin with Asp33 replaced by Cys was expressed in yeast and isolated by HPLC.
Meyhack, Bernd +7 more
core +1 more source