Results 31 to 40 of about 12,117 (216)
Diselenide crosslinks for enhanced and simplified oxidative protein folding
Communications Chemistry, 2021 Hirudin is a widely studied model for folding of disulfide-rich proteins, which folds through a slow pathway with highly heterogeneous intermediates and scrambled isomers before it reaches its native state.
Reem Mousa +7 more
doaj +1 more source
Asian Journal of Pharmaceutical Sciences, 2022 Cardiovascular disease is the leading cause of global mortality, with anticoagulant therapy being the main prevention and treatment strategy. Recombinant hirudin (r-hirudin) is a direct thrombin inhibitor that can potentially prevent thrombosis via ...
Mengfang Wu +9 more
doaj +1 more source
Platelets, 2023 Citrate is widely used as an anticoagulant for platelet function tests (PFTs). Due to an intrinsic inhibitory effect of citrate on platelet function, hirudin is used as an alternative.
Wasanthi Wickramasinghe +10 more
doaj +1 more source
Hirudin ameliorates immunoglobulin A nephropathy by inhibition of fibrosis and inflammatory response
Renal Failure, 2019 Immunoglobulin A nephropathy (IgAN) is characterized by mesangial IgA and IgG co-deposition. As the clinical course of IgAN is highly variable, a lot of patients will eventually develop to end-stage renal disease (ESRD) within years.
Fei Deng +6 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Approximately 10%-20% of patients with acute cardiovascular disease who have received coronary intervention suffer restenosis and high inflammation.
Hongmei Li, Xian Wang, Anlong Xu
doaj +1 more source
A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA. [PDF]
PLoS ONE, 2013 Therapeutic oligonucleotides including siRNA and immunostimulatory ligands of Toll-like receptors (TLR) or RIG-I like helicases (RLH) are a promising novel class of drugs. They are in clinical development for a broad spectrum of applications, e.g.
Christoph Coch +8 more
doaj +1 more source
Serotonin reuptake inhibitors and cardiovascular disease [PDF]
, 2005 Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Belcher, P.R. +2 more
core +1 more source
Structural Analysis of Hirudin Using FT-IR and FT-Raman Spectroscopic Techniques [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2000 FT-IR and FT-Raman spectra of hirudin have been recorded from the native solid hirudin. The conformation of the molecule has been discussed on the basis of IR and Raman data. It has been concluded that hirudin molecule has a mixed a-helix and random coil
Amanollah Aminzadeh
doaj
Recombinant hirudin attenuates pulmonary hypertension and thrombosis in acute pulmonary embolism rat model [PDF]
PeerJBackground Acute pulmonary embolism (APE) is classified as a subset of diseases that are characterized by lung obstruction due to various types of emboli.
Xiang Wei +5 more
doaj +2 more sources