Results 31 to 40 of about 6,653 (173)

Recombinant hirudin attenuates pulmonary hypertension and thrombosis in acute pulmonary embolism rat model [PDF]

PeerJ
Background Acute pulmonary embolism (APE) is classified as a subset of diseases that are characterized by lung obstruction due to various types of emboli.
Xiang Wei, Yanfen Zou, Shunli Dong, Yi Chen, Guoping Li, Bin Wang   +5 more
doaj   +2 more sources

A human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNA. [PDF]

PLoS ONE, 2013
Therapeutic oligonucleotides including siRNA and immunostimulatory ligands of Toll-like receptors (TLR) or RIG-I like helicases (RLH) are a promising novel class of drugs. They are in clinical development for a broad spectrum of applications, e.g.
Christoph Coch, Christian Lück, Anna Schwickart, Bastian Putschli, Marcel Renn, Tobias Höller, Winfried Barchet, Gunther Hartmann, Martin Schlee   +8 more
doaj   +1 more source

Hirudin promotes cerebral angiogenesis and exerts neuroprotective effects in MCAO/R rats by activating the Wnt/β-catenin pathway

Journal of Stroke and Cerebrovascular Diseases
Objective: Hirudin has shown potential in promoting angiogenesis and providing neuroprotection in ischemic stroke; however, its therapeutic role in promoting cerebrovascular angiogenesis remains unclear.
Linrong He, Ruolan Lei, Shuangyang Li, Xiaoying Zhao, Xinying He, Xinyue Yang, Ping Liu, Dechou Zhang, Yu Jiang   +8 more
doaj   +1 more source

PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence

Biomedicines
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease for which there is a lack of effective pharmacological treatments. Hirudin, a natural peptide extracted from leeches, has been used for broad pharmacological purposes. In
Bin He, Qian Zeng, Yumei Tian, Yuyang Luo, Minlin Liao, Wenjie Huang, Bin Wu, Ziqiang Luo, Xiaoting Huang, Wei Liu, Siyuan Tang   +10 more
doaj   +1 more source

Measurement of Active Thrombin Bound to Circulating D‐Dimers as a Sensitive Biomarker for Prothrombotic Conditions

Journal of Clinical Laboratory Analysis, EarlyView.
Scheme of preparation of D‐dimers and evaluation of D‐dimer‐bound thrombin activity. Thrombin bound to fibrin participates in ongoing fibrinogen transformation and its inhibition is impeded. Our detection system may aid in identifying patients at risk of recurrent thrombotic events or complications, regardless of the origin of the acute health problem.
Jana Stikarova, Leona Chrastinova, Kristyna Svobodova, Marek Havlicek, Jan Louzil, Eliska Ceznerova, Alzbeta Hlavackova, Ondrej Pastva, Pavla Pecherkova, Ingrid Hrachovinova, Ondrej Kucerka, Roman Kotlin, Petr Soukup, Peter Salaj, Martin Maly, Jiri Suttnar   +15 more
wiley   +1 more source

Altered cytoskeletal integrity underlies impaired platelet shape change and defective thrombus formation in ETV6‐related thrombocytopenia

British Journal of Haematology, EarlyView.
Summary ETV6‐related thrombocytopenia (ETV6‐RT) is an inherited platelet disorder caused by germline ETV6 variants. Despite recent progress, the mechanisms underlying platelet dysfunction in ETV6‐RT remain unclear. We investigated 12 patients from six families using functional assays, electron microscopy, quantitative proteomics and cytoskeletal ...
Ivan P. Tesakov, Julia‐Jessica D. Korobkin, Daria V. Fedorova, Sofia V. Galkina, Maria M. Golomysova, Sergei I. Obydennyi, Anastasia A. Ignatova, Ekaterina‐Iva A. Adamanskaya, Eugenia V. Yushkova, Anna V. Pavlova, Pavel A. Zharkov, Igor I. Kireev, Galina A. Novichkova, Viktor G. Zgoda, Mikhail A. Panteleev, Anastasia N. Sveshnikova   +15 more
wiley   +1 more source

Whole blood platelet aggregation determined by the ROTEM platelet equipment; reference intervals and stability

Platelets, 2020
Point of care testing of residual effect of antiplatelet therapy in trauma patients or during major surgery may result in improved clinical management of significant bleeding. We included 121 healthy individuals (57 females and 64 males, aged 22–65 years)
Peter H. Nissen, Mette Tiedemann Skipper, Anne-Mette Hvas   +2 more
doaj   +1 more source

Leech therapy in the treatment of a penile haematoma in a stallion

Veterinární Medicína, 2021
Treatment of penile haematomas includes conventional therapy and/or surgical intervention which may not always result in the recovery of all penile functions.
A Nowicki, J Jaworska, W Baranski
doaj   +1 more source

Bioresorbable Scaffolds for Coronary Arteries: Where Do We Stand Today?

VIEW Medicine, Volume 1, Issue 1, August 2026.
Bioresorbable coronary scaffolds are moving from thick strut pitfalls to thinner, stronger, healing‐oriented designs. Integrating advances in materials, guided implantation with preparation, size, and postdilation steps, and resorption aligned to healing, we synthesize clinical evidence and chart a roadmap toward intelligent, transient platforms ...
Junya Matsuda, Tatsuya Watanabe, Satoshi Yuhara, John M. Kelly, Hirotsugu Kurobe, Toshiharu Shinoka   +5 more
wiley   +1 more source

Reconstructing the Post‐Burn Auricle: A Microsurgical Approach Using a Contralateral Free Temporoparietal Fascial Flap and Autologous Costal Cartilage Framework

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Post‐burn auricular defects compromise both aesthetics and facial symmetry, often imposing significant social and psychological burdens that severely diminish patients' quality of life. Scarring in the mastoid region following burns typically exhibits poor elasticity and texture, along with compromised cutaneous blood supply.
Siming Wei, Yongjun Chen, Liwei Dong
wiley   +1 more source