Results 21 to 30 of about 6,653 (173)
Cell Transplantation, 2006 Human islets induce an injurious clotting reaction at the time of transplantation. A potential strategy to counteract this reaction would be to allow the islets to express hirudin, a protein with direct anticoagulative activity.
Sanja Cabric +4 more
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Pharmacokinetics study of recombinant hirudin in the plasma of rats using chromogenic substrate, ELISA, and radioisotope assays. [PDF]
PLoS ONE, 2013 AIM: To compare the analytical methods used to study the pharmacokinetics of recombinant hirudin in the plasma of rats that had been injected with (125)I-recombinant hirudin.
Su-Yun Jiang +3 more
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Comparison between Topical Beta-sitosterol and Topical Hirudin in Management of Facial Burns
Egyptian Journal of Plastic and Reconstructive Surgery, 2023 Background: Facial burns are challenging, as the aesthetic outcome is as important as the functional. Topical interventions are currently the cornerstone of treatment of facial burns.
nourhan mohamed +3 more
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The effect of recombinant hirudin on rabbit ear flaps with venous insufficiency
Indian Journal of Plastic Surgery, 2014 The effect of recombinant hirudin, which is the most powerful antithrombotic agent, on flaps with venous insufficiency was investigated. Oedema and congestion are frequent on flaps, causing necrosis unpredictably.
Serdar Duzgun +2 more
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Diselenide crosslinks for enhanced and simplified oxidative protein folding
Communications Chemistry, 2021 Hirudin is a widely studied model for folding of disulfide-rich proteins, which folds through a slow pathway with highly heterogeneous intermediates and scrambled isomers before it reaches its native state.
Reem Mousa +7 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: Approximately 10%-20% of patients with acute cardiovascular disease who have received coronary intervention suffer restenosis and high inflammation.
Hongmei Li, Xian Wang, Anlong Xu
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Platelets, 2023 Citrate is widely used as an anticoagulant for platelet function tests (PFTs). Due to an intrinsic inhibitory effect of citrate on platelet function, hirudin is used as an alternative.
Wasanthi Wickramasinghe +10 more
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Hirudin ameliorates immunoglobulin A nephropathy by inhibition of fibrosis and inflammatory response
Renal Failure, 2019 Immunoglobulin A nephropathy (IgAN) is characterized by mesangial IgA and IgG co-deposition. As the clinical course of IgAN is highly variable, a lot of patients will eventually develop to end-stage renal disease (ESRD) within years.
Fei Deng +6 more
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Asian Journal of Pharmaceutical Sciences, 2022 Cardiovascular disease is the leading cause of global mortality, with anticoagulant therapy being the main prevention and treatment strategy. Recombinant hirudin (r-hirudin) is a direct thrombin inhibitor that can potentially prevent thrombosis via ...
Mengfang Wu +9 more
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Structural Analysis of Hirudin Using FT-IR and FT-Raman Spectroscopic Techniques [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2000 FT-IR and FT-Raman spectra of hirudin have been recorded from the native solid hirudin. The conformation of the molecule has been discussed on the basis of IR and Raman data. It has been concluded that hirudin molecule has a mixed a-helix and random coil
Amanollah Aminzadeh
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