Results 1 to 10 of about 7,899 (213)

Retention of critical platelet hemostatic functions of amotosalen‐UVA pathogen‐reduced cryoprecipitated fibrinogen complex

Transfusion, Volume 66, Issue 2, Page 393-404, February 2026.
Abstract Background Cryoprecipitate Anti‐Haemophilic Factor (CRYO‐AHF) is enriched for fibrinogen, VWF, FVIII, FXIII and fibronectin, but has short post‐thaw expiration due to risk of transfusion‐transmitted infection (TTI) limiting availability for rapid treatment.
Florian Tupin, Clarisse Mouriaux, Michelle Gatmaitan, Kaja Kaastrup, Subramanian Yegneswaran, Laurence Corash, Pierre H. Mangin   +6 more
wiley   +1 more source

Hirudin inhibit the formation of NLRP3 inflammasome in cardiomyocytes via suppressing oxidative stress and activating mitophagy

Heliyon
Context: Cardiomyocyte hypertrophy due to hemodynamic overload eventually leads to heart failure. Hirudin has been widely used in the treatment of cardiovascular diseases and NLRP3 inflammasome was proven to induce cardiomyocyte pyroptosis.
Gang Luo, Li Chen, Mingtai Chen, Linshen Mao, Qihu Zeng, Yuan Zou, Jinyi Xue, Ping Liu, Qibiao Wu, Sijin Yang, Mengnan Liu   +10 more
doaj   +1 more source

Hirudotherapy in Medicine and Dentistry [PDF]

Journal of Clinical and Diagnostic Research, 2015
The concept of Unani medicine is based on balancing body humours, the imbalance of which causes diseases. The application of leech therapy in medical and dental science is well recognized. Although easy and non-invasive, complications also exist.
Kunal Jha, Aarti Garg, Ridhi Narang, Sunanda Das   +3 more
doaj   +1 more source

Mechanism of the inhibition of α‐thrombin by hirudin‐derived fragments hirudin(1–47) and hirudin(45–65) [PDF]

European Journal of Biochemistry, 1991
The kinetic mechanism of the inhibition of α‐thrombin by hirudin was analyzed using the hirudin‐derived fragments hirudin(1–47) and hirudin(45–65). Previously, these fragments have been shown to interact with α‐thrombin at distinct sites inhibiting thrombin‐mediated clot formation.
T, Schmitz, M, Rothe, J, Dodt
openaire   +2 more sources

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

European Medicinal Leeches—New Roles in Modern Medicine

Biomedicines, 2020
Before the advent of modern medicine, natural resources were widely used by indigenous populations for the prevention and treatment of diseases. The associated knowledge, collectively described as folk medicine or traditional medicine, was largely based ...
Sarah Lemke, Andreas Vilcinskas
doaj   +1 more source

eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

Small, Volume 22, Issue 1, 2 January 2026.
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha, Yeonji Kim, Subin Park, Hu‐Lin Jiang, Jae‐Young Lee, Daesik Kim, Jee‐Heon Jeong   +6 more
wiley   +1 more source

Evaluating the Effect of Protein A Signal Peptide on Extracellular Expression of Recombinant Hirudin in E.Coli

Medical Laboratory Journal, 2015
Background and Objective: Hirudin is an anticoagulant polypeptide secreted from the salivary glands of leeches. Recombinant hirudin is a strong anticoagulant agent in arterial and venous thrombosis.
Parisa Bakhshi, Massoud Saidijam, Delavar Shahbazzadeh, Nazanin Mohajerani, Hassan Mirzahoseini   +4 more
doaj  

Comparison between Topical Beta-Sitosterol and Topical Hirudin in Management of Facial Burns [PDF]

Egyptian Journal of Plastic and Reconstructive Surgery
Background: Facial burns are challenging, as the aestheticoutcome is as important as the functional. Topical interventionsare currently the cornerstone of treatment of facial burns.Although there is no gold standard agent for the treatment offacial burns,
Nourhan Mohamed, Ahmed Abolnaga, Amr Moghazy, Amr Gomaa   +3 more
doaj   +1 more source

Testicular Compartment Syndrome Post Bilateral Microdissection Testicular Sperm Extraction: A Case Report and Review of the Current Literature

Case Reports in Urology, Volume 2026, Issue 1, 2026.
Background Testicular compartment syndrome (TCS) is a rare phenomenon with around 14 cases reported in the literature. It occurs when extraluminal compression or increased venous resistance leads to raised intratesticular pressure. The fibrous tunica albuginea covering the testes does not distend, meaning the pressure is not relieved and compartment ...
Catherine Larard, Katie McComb, Ivo Donkov, Alberto Coscione, Panagiotis Nikolinakos, Karl H. Pang, Suraiya Saleem   +6 more
wiley   +1 more source