Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review
Frontiers in Pharmacology, 2021 Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as “Shuizhi” in traditional Chinese medicine), is the strongest natural specific inhibitor of thrombin found so far. Hirudin has been demonstrated to possess
Chen Junren +22 more
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Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway [PDF]
Acta Cirúrgica BrasileiraPurpose: To reveal the role and underlying mechanism of hirudin in renal fibrosis. Methods: The unilateral ureteral obstruction (UUO) rat model and ferroptosis activator RSL3-induced human kidney proximal tubular epithelial cells (HK-2) were established.
Fang Lan +4 more
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The Advances in Novel Delivery Strategies for Hirudin Against Cardiovascular Diseases [PDF]
PharmaceuticalsThe natural polypeptide drug hirudin, a direct thrombin inhibitor, exhibits potent anticoagulant, anti-myocardial fibrotic, and anti-inflammatory effects in the treatment of cardiovascular diseases (CVD), but its clinical application remains limited by ...
Mengjing Li +7 more
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A Biomimetic Macrophage-Membrane-Fused Liposomal System Loaded with GVs-HV Recombinant Plasmid for Targeted Anti-Atherosclerosis Therapy [PDF]
PharmaceuticsBackground: Cardiovascular disease is one of the leading causes of death worldwide. The presence of atherosclerotic plaques in the arteries leads to continuous growth and obstruction of blood vessels, which ultimately leads to acute myocardial infarction
Yuelin Zhang +9 more
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Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease [PDF]
European Journal of HistochemistryChronic kidney disease (CKD) is a progressive disorder characterized by renal fibrosis, inflammation, and dysregulated autophagy and apoptosis. High-mobility group box 1 (HMGB1) plays a crucial role in regulating autophagy in CKD.
Ying Li +5 more
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Expression of Recombinant Hirudin in Bacteria and Yeast: A Comparative Approach [PDF]
Methods and ProtocolsThe expression of recombinant proteins in heterologous hosts is a common strategy to obtain larger quantities of the “protein of interest” (POI) for scientific, therapeutic or commercial purposes.
Zhongjie Wang +3 more
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Comparative Study of Hirudins and Encoding Genes in Hirudo nipponia and Hirudo tianjinensis [PDF]
BiologyThis study systematically compared the genetic characteristics and functional activities of hirudins and their encoding genes between Hirudo nipponia (Hnip1–3) and Hirudo tianjinensis (Htia1–3) through bioinformatics analysis, recombinant protein ...
Jingjing Yin +7 more
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Recombinant neorudin and its active metabolite hirudin: the fate in vivo of a novel anticoagulant drug [PDF]
Frontiers in PharmacologyThrombosis, a prevalent condition, can provoke severe health issues like acute coronary syndrome (ACS), deep vein thrombosis (DVT), and pulmonary embolism (PE).
Qiang Li +7 more
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Recent progress on formulations of hirudin [PDF]
Pharmaceutical Science AdvancesHirudin is an effective active ingredient derived from the salivary glands of leech. It is a small peptide molecule consisting of 65–66 amino acids and demonstrates a strong inhibitory effect on thrombin, providing beneficial anticoagulant and ...
Zheng Bao +8 more
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Frontiers in Pharmacology, 2022 Background: Myocardial hypertrophy is a complex pathological process, which is a common manifestation during the development of various cardiovascular diseases.
Mengnan Liu +11 more
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