Scientific Reports, 2023 Hirudin is a pharmacologically active substance in leeches with potent blood anticoagulation properties. Although recombinant hirudin production isolated from Hirudo medicinalis Linnaeus and Hirudinaria manillensis Lesson is known, to our knowledge, this
Ping Shi +5 more
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Identification and characterization of hirudin-HN, a new thrombin inhibitor, from the salivary glands of Hirudo nipponia [PDF]
PeerJ, 2019 Transcriptome sequencing data (6.5 Gb) of the salivary glands of the haematophagous leech Hirudo nipponia was obtained by using the BGIseq-500 platform.
Boxing Cheng +6 more
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Frontiers in Pharmacology, 2021 Background: Hirudin has been widely used in the treatment of antifibrosis. Previous studies have shown that hirudin can effectively improve the clinical remission rate of chronic kidney disease. However, the mechanism of its renal protection has not been
Hang-Xing Yu +18 more
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Thrombin regulates the ability of Schwann cells to support neuritogenesis and to maintain the integrity of the nodes of Ranvier [PDF]
, 2020 Schwann cells (SC) are characterized by a remarkable plasticity that enables them to promptly respond to nerve injury promoting axonal regeneration. In peripheral nerves after damage SC convert to a repair-promoting phenotype activating a sequence of ...
Ciraci, Viviana +9 more
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Expression, purification, and mass spectrometric analysis of 15N, 13C-labeled RGD-hirudin, expressed in Pichia pastoris, for NMR studies. [PDF]
PLoS ONE, 2012 A novel recombinant hirudin, RGD-hirudin, inhibits the activity of thrombin and the aggregation of platelets. Here, we successfully expressed (15)N, (13)C-labeled RGD-hirudin in Pichia pastoris in a fermenter.
Yinong Huang +8 more
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An Aptamer-Based EXACT Anticoagulant as a Sustainable, Animal-Free Alternative to Unfractionated Heparin. [PDF]
Adv Sci (Weinh)By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Yu H +11 more
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Scrotal Hirudiniasis: The Mysterious Migration of a Leech Into the Scrotum: A Case Report. [PDF]
Clin Case RepABSTRACT Hirudiniasis, or leech infestation, is a rare parasitic condition typically involving external skin or mucosal surfaces. We report a case of scrotal hirudiniasis, an 11 cm long leech discovered within the scrotal sac of a 15‐year‐old male.
Chakroborty P, Quadir MA.
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The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells [PDF]
Acta Cirúrgica Brasileira, 2019 Purpose: To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis.
Jiangying Zhu +6 more
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The effects of a hirudin/liposome complex on a diabetic nephropathy rat model
BMC Complementary and Alternative Medicine, 2019 Background Hirudin, an extract from Hirudo spp., is an anticoagulant used to treat a variety of renal diseases, including diabetic nephropathy (DN).
Hongwu Wang +8 more
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Traditional Chinese Medicinal Leech Induces Apoptosis and Autophagy in Glioblastoma by SGK1/Caspase-3 and PI3K/AKT/mTOR Pathway. [PDF]
CNS Neurosci TherSchematic representation of the underlying molecular mechanisms by which leech mediates apoptosis and autophagy through SGK1/Caspase‐3 and PI3K/AKT/mTOR pathways to inhibit glioblastoma. ABSTRACT Background Glioblastoma (GBM) represents the most lethal form of high‐grade glioma, with current therapeutic options proving largely ineffective. Consequently,
Wu S, Zhou Y, Pei Z, Wang Y, Zhang Z.
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