Laryngeal Leech as a Live Foreign Body: Case Reports and a Safe Removal Technique. [PDF]
Case Rep OtolaryngolLeech infestation in the larynx is a rare condition with serious implications due to airway obstruction and persistent bleeding. This report presents two cases of dysphonia and hemoptysis caused by laryngeal leeches after consuming contaminated water.
Mohebbi M +6 more
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Identification and characterization of hirudin-HN, a new thrombin inhibitor, from the salivary glands of Hirudo nipponia [PDF]
PeerJ, 2019 Transcriptome sequencing data (6.5 Gb) of the salivary glands of the haematophagous leech Hirudo nipponia was obtained by using the BGIseq-500 platform.
Boxing Cheng +6 more
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Catabolism of hirudin and thrombin-hirudin complexes in the rat [PDF]
Biochemical Journal, 1993 The metabolic fate of the anticoagulant protein, hirudin, and its complex with thrombin are presently unknown. Therefore we have labelled hirudin and human thrombin-hirudin complex with the residualizing label dilactitol-125I-tyramine (*I-DLT) in order to identify their tissue sites of catabolism in the rat.
Bichler, Johann +2 more
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Frontiers in Pharmacology, 2021 Background: Hirudin has been widely used in the treatment of antifibrosis. Previous studies have shown that hirudin can effectively improve the clinical remission rate of chronic kidney disease. However, the mechanism of its renal protection has not been
Hang-Xing Yu +18 more
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Expression, purification, and mass spectrometric analysis of 15N, 13C-labeled RGD-hirudin, expressed in Pichia pastoris, for NMR studies. [PDF]
PLoS ONE, 2012 A novel recombinant hirudin, RGD-hirudin, inhibits the activity of thrombin and the aggregation of platelets. Here, we successfully expressed (15)N, (13)C-labeled RGD-hirudin in Pichia pastoris in a fermenter.
Yinong Huang +8 more
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Preparation of monoclonal antibodies to hirudin and hirudin peptides [PDF]
European Journal of Biochemistry, 1990 A panel of four monoclonal antibodies was obtained against hirudin, a potent and specific inhibitor of thrombin, by immunizing three groups of mice with protein conjugates made of recombinant desulfatohirudin (group I) or two synthetic peptides representing the C‐terminal sequences 40–65 (group II) and 52–65 (group III) of hirudin.
J M, Schlaeppi +3 more
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The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells [PDF]
Acta Cirúrgica Brasileira, 2019 Purpose: To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis.
Jiangying Zhu +6 more
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The effects of a hirudin/liposome complex on a diabetic nephropathy rat model
BMC Complementary and Alternative Medicine, 2019 Background Hirudin, an extract from Hirudo spp., is an anticoagulant used to treat a variety of renal diseases, including diabetic nephropathy (DN).
Hongwu Wang +8 more
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An Aptamer-Based EXACT Anticoagulant as a Sustainable, Animal-Free Alternative to Unfractionated Heparin. [PDF]
Adv Sci (Weinh)By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Yu H +11 more
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Scrotal Hirudiniasis: The Mysterious Migration of a Leech Into the Scrotum: A Case Report. [PDF]
Clin Case RepABSTRACT Hirudiniasis, or leech infestation, is a rare parasitic condition typically involving external skin or mucosal surfaces. We report a case of scrotal hirudiniasis, an 11 cm long leech discovered within the scrotal sac of a 15‐year‐old male.
Chakroborty P, Quadir MA.
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