Results 71 to 80 of about 12,117 (216)
Evidence that heparin but not hirudin reduces PAI-1 expression in cultured human endothelial cells [PDF]
, 1999 Heparin and other antithrombotic drugs besides their anticoagulant action could have a profibrinolytic effect. We have analyzed the effect of unfractionated heparin (UFH) and hirudin on PAI-1 gene expression in human umbilical vein endothelial cells ...
Montes, R. (Ramón) +4 more
core +1 more source
Veterinary Medicine International, Volume 2026, Issue 1, 2026.The livestock industry in Ethiopia suffers greatly from parasites and parasitic diseases including leech infestation. Leech infestation is a serious disease of animals and occasionally humans, but it is usually ignored. A cross‐sectional study design was carried out from January 2022 to June 2022 to estimate the prevalence of leech infestation in ...
Moges Maru +11 more
wiley +1 more source
Medical Laboratory Journal, 2015 Background and Objective: Hirudin is an anticoagulant polypeptide secreted from the salivary glands of leeches. Recombinant hirudin is a strong anticoagulant agent in arterial and venous thrombosis.
Parisa Bakhshi +4 more
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Effects of hirudin-induced activation of nonenzymatic fibrinolysis during immobilization stress [PDF]
The specific inhibitor of thrombin, hirudin, was used for studying the mechanism of the activating effect of ACTH and adrenalin on nonenzymatic fibrinolytic activity (NEFA), the latter characterizing the function of the anticoagulation system (ACS ...
Baskova, I. P. +4 more
core +1 more source
Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]
, 2017 Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J. +7 more
core +2 more sources
Improvement of Hemocompatibility in Passive Cardiovascular Implant Devices
Advanced Therapeutics, Volume 8, Issue 12, December 2025.With the ever‐increasing reliance on cardiovascular devices and implants, minimizing their impact on blood is vital for their continued success. This review investigates the common methods of tackling this challenge through careful selections of material and surface modifications.
Shiyen L. Perera +4 more
wiley +1 more source
Advanced Science, Volume 12, Issue 42, November 13, 2025.An injectable PSA‐ZnO through multiple intermolecular including hydrogen bonds and electrostatic interactions for effectively prevents abdominal adhesions. The PSA‐ZnO hydrogel demonstrates superior wound healing promotion (≥ 95%) and more effective inhibition of scar formation compared to the commercial 3M dressing (≈80%), and prevents post‐operative ...
Na Wen +9 more
wiley +1 more source
MedComm, Volume 6, Issue 11, November 2025.Summary of PCSK9 inhibitor mechanisms. PCSK9 inhibitors (PCSK9‐i) primarily lower LDL‐cholesterol (LDL‐C) by blocking PCSK9‐mediated degradation of hepatic LDL receptors (LDLR), enhancing LDL clearance. Beyond LDLR‐dependent effects, PCSK9‐i exert multiple benefits via LDLR‐independent pathways.
Jia Kuang +3 more
wiley +1 more source
Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue [PDF]
, 2009 The ubiquitous thioredoxin fold proteins catalyze oxidation, reduction, or disulfide exchange reactions depending on their redox properties. They also play vital roles in protein folding, redox control, and disease.
Guoping Ren +66 more
core +3 more sources
The Antithrombotic Effect of Recombinant Neorudin on Thrombi
Drug Design, Development and Therapy, 2022 Yu-Bin Liu,1 Lin Zhang,1 Xing-Chen Zhou,1 Ying Zhou,1 Yun Liu,1 Can Zheng,1 Xiao Xu,1 Pan-Pan Geng,1 Chun-Hua Hao,2 Zhuan-You Zhao,2 Chu-Tse Wu,1 Ji-De Jin1 1Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine,
Liu YB +11 more
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