Results 31 to 40 of about 330,244 (384)

Histamine and the striatum

Neuropharmacology, 2016
The neuromodulator histamine is released throughout the brain during periods of wakefulness. Combined with an abundant expression of histamine receptors, this suggests potential widespread histaminergic control of neural circuit activity. However, the effect of histamine on many of these circuits is unknown.
Bolam, J. Paul, Ellender, Tommas J.
openaire   +4 more sources

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Frontiers in Pharmacology, 2021
This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart.
Joachim Neumann, Uwe Kirchhefer, Stefan Dhein, Britt Hofmann, Ulrich Gergs   +4 more
doaj   +1 more source

Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis

Acta Dermato-Venereologica, 2020
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied by itch.
Kristine Rossbach, Katharina Wahle, Gustav Bruer, Ralph Brehm, Marion Langeheine, Kristina Rode, Katrin Schaper-Gerhardt, Ralf Gutzmer, Thomas Werfel, Manfred Kietzmann, Wolfgang Bäumer   +10 more
doaj   +1 more source

Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review

Brain Sciences, 2023
Background: Histamine is a widely distributed biogenic amine with multiple biological functions mediated by specific receptors that determine the local effects of histamine.
Lingyi Kong, Ewa Domarecka, Agnieszka J. Szczepek   +2 more
doaj   +1 more source

Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine. [PDF]

, 2019
Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA has rarely been reported due to its small size to induce the desired antibodies ...
Dong, Jie-Xian, Hammock, Bruce, Jia, Bao-Zhu, Lei, Hong-Tao, Luo, Lin, Shen, Yu-Dong, Wang, Hong, Wei, Xiao-Qun, Xu, Zhen-Lin, Yang, Jin-Yi   +9 more
core   +1 more source

Histamine, histamine receptors, and neuropathic pain relief

British Journal of Pharmacology, 2019
Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various physiological and pathological processes, including pain. In the last two decades, there has been a particular increase in evidence to support the involvement of H3 ...
I. Obara, V. Telezhkin, Ibrahim Alrashdi, P. Chazot   +3 more
semanticscholar   +1 more source

Histamine promotes angiogenesis through a histamine H1 receptor-PKC-VEGF-mediated pathway in human endothelial cells

Journal of Pharmacological Sciences, 2023
Histamine is a well-known inflammatory mediator, but how histamine induces angiogenesis remains poorly understood. In the present study, we demonstrated a dose-dependent dynamic tube formation in the human endothelial cell line EA.hy926 in the presence ...
Omer Faruk Hatipoglu, Takashi Nishinaka, Masahiro Nishibori, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Kursat Oguz Yaykasli, Hidenori Wake, Hideo Takahashi   +8 more
doaj  

Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome.

Gastroenterology, 2016
BACKGROUND & AIMS Histamine sensitizes the nociceptor transient reporter potential channel V1 (TRPV1) and has been shown to contribute to visceral hypersensitivity in animals.
M. Wouters, Dafne Balemans, S. van Wanrooy, J. Dooley, V. Cibert-Goton, Y. A. Alpizar, Eduardo E Valdez-Morales, Y. Nasser, P. V. Van Veldhoven, Winde Vanbrabant, Schalk van der Merwe, R. Mols, B. Ghesquière, C. Cirillo, I. Kortekaas, P. Carmeliet, W. Peetermans, S. Vermeire, P. Rutgeerts, P. Augustijns, P. Hellings, A. Belmans, S. Vanner, D. Bulmer, K. Talavera, P. Vanden Berghe, A. Liston, G. Boeckxstaens   +27 more
semanticscholar   +1 more source

H3 histamine receptor-mediated activation of protein kinase calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo [PDF]

, 2009
Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The D-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth.
A. Vetuschi, F. Y. Meng, FRANCHITTO, Antonio, G. Alpini, G. Carpino, GAUDIO, EUGENIO, H. Francis, J. Venter, M. White, MANCINELLI, ROMINA, ONORI, PAOLO, R. Sferra, S. Demorrow, S. Kopriva   +13 more
core   +1 more source

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms [PDF]

, 2018
Platelet-activating factor (PAF) stimulates numerous cell types via activation of the G protein-coupled PAF receptor (PAFR). PAFR activation not only induces acute proinflammatory responses, but it also induces delayed systemic immunosuppressive effects ...
FitzGerald, Garret A., Kaplan, Mark H., Ocana, Jesus A., Pawelzik, Sven-Christian, Romer, Eric, Sahu, Ravi, Travers, Jeffrey B.   +6 more
core   +1 more source