In vitro studies with GI surgical specimens or biopsy are a critical step in translating preclinical studies in animals to humans before testing potential therapeutic interventions in expensive clinical trials. Routine availability of human gut specimens, in combination with technological advances and powerful new in vitro models of the human ENS from ...
Dmitrii Pavlov, Fievos L. Christofi
wiley +1 more source
COMPARISONS OF VARIOUS HISTAMINE ANTAGONISTS [PDF]
openaire +3 more sources
Effect of Histamine-2 Receptor Antagonists on Hypocalcemia after Thyroidectomy: A Retrospective Cohort Study and Sensitivity Analysis. [PDF]
Rossip M+6 more
europepmc +1 more source
This article presents the outcomes of a three‐tiered outpatient treatment algorithm for the prophylactic management of cyclical vomiting syndrome (CVS). Three key messages: (1) 61% of patients responded to the treatment algorithm, (2) opioid cessation was associated with clinical response to the treatment algorithm (p = 0.03), and (3) a low‐dose ...
Mohsin F. Butt+4 more
wiley +1 more source
HDC/histamine Signaling Axis Drives Macrophage Reprogramming to Promote Angiogenesis in Hindlimb-Ischemic Mice. [PDF]
Sun D+10 more
europepmc +1 more source
Defective lymphatic vasculature in obesity
Summary Lymphedema is an important, and often underdiagnosed complication of obesity and is likely due to acquired defects in the lymphatic vasculature. Study of diet‐induced obesity animal models have indicated defective lymphatic vasculatures might extend to other anatomical sites, especially visceral depots.
Jingjing Zhu, John P. H. Wilding, Ji Hu
wiley +1 more source
Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice. [PDF]
Kaita S+3 more
europepmc +1 more source
Evaluation of dipeptidyl peptidase-4 inhibitor-associated gastrointestinal symptoms using the prescription claims database. [PDF]
Funabashi A+5 more
europepmc +1 more source
Oxyntomodulin physiology and its therapeutic development in obesity and associated complications
Abstract figure legend Physiological influences of OXM and its emerging insights from evidence on bariatric surgery effects. CCK, cholecystokinin; FGF21, fibroblast growth factor 21; GLUT4, glucose transporter type 4; IRS1, insulin receptor substrate‐1; NNMT, nicotinamide N‐methyltransferase; OXM, oxyntomodulin Abstract Incretins, such as glucagon‐like
Martin T. W. Kueh+3 more
wiley +1 more source