Results 181 to 190 of about 46,942 (270)
Cancer Innovation, Volume 4, Issue 3, June 2025.ABSTRACT Background The phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a critical role in breast cancer pathogenesis and progression, and is closely linked with resistance to endocrine therapy in advanced breast cancer.
The Breast Cancer Expert Committee of the National Quality Control Center for Cancer +3 more
wiley +1 more source
Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets
ESC Heart Failure, Volume 12, Issue 3, Page 1739-1758, June 2025.Abstract The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune ...
Gen Li, Wu He, Dao Wen Wang
wiley +1 more source
Histamine-induced cytosolic calcium mobilization in human bronchial smooth muscle cells. [PDF]
J Smooth Muscle ResChoi KJ +4 more
europepmc +1 more source
The Essentiality of Amino Acids in Healthiness and Disease State: Type II Diabetes as a Case Study
Food Science &Nutrition, Volume 13, Issue 6, June 2025.This review investigates the functions of amino acids in normal physiological states, their potential as a diagnostic biomarker, the probable risk of deficiency, and the therapeutic ability for managing and preventing type 2 diabetes mellitus. ABSTRACT A healthy life depends on the availability and the synthesis of amino acids as they are building ...
Samuel Idowu Fayomi +2 more
wiley +1 more source
The developmental toxicity of the H1 histamine antagonists
Reproductive Toxicology, 1996 Anthony R. Scialli, Armand Lione
openaire +3 more sources
International Journal of Cancer, Volume 156, Issue 11, Page 2225-2236, 1 June 2025.What's new? Despite advances, the efficacy of current immune checkpoint inhibitor therapies remains suboptimal in non‐small cell lung cancer due to the immunosuppressive tumor microenvironment. Here, ILT5 was found to be highly expressed in tumor‐associated macrophages from non‐small cell lung cancer tissues and associated with poor patient survival ...
Huijun Xu +10 more
wiley +1 more source
GnRH Peptide Antagonist: Comparative Analysis of Chemistry and Formulation with Implications for Clinical Safety and Efficacy. [PDF]
Pharmaceuticals (Basel)Patel S, Saxena B, Mehta P, Niazi SK.
europepmc +1 more source
Acta Psychiatrica Scandinavica, Volume 151, Issue 6, Page 719-730, June 2025.ABSTRACT Background Metformin shows potential in combating clozapine‐induced weight gain (CIWG). However, current evidence for its use remains limited. Through an audit we determined the prevalence of metformin use among clozapine‐treated patients and its impact on weight and waist circumference (WC).
Bee Leng Per +5 more
wiley +1 more source
Risk factors for Clostridioides difficile infection caused by ribotype 027 strains in the Veterans Affairs Healthcare System: a matched case-control study. [PDF]
Antimicrob Resist Infect ControlSilva SY, Wilson BM, Donskey CJ.
europepmc +1 more source
Engineered pulmonary artery tissues for measuring contractility, drug testing and disease modelling
British Journal of Pharmacology, Volume 182, Issue 12, Page 2585-2602, June 2025.Abstract Background and Purpose Vasoreactivity of pulmonary arteries regulates blood flow through the lungs. Excessive constriction of these vessels contributes to pulmonary arterial hypertension (PAH), a progressive and incurable condition, resulting in right heart failure.
Adam L. Fellows +8 more
wiley +1 more source