Results 151 to 160 of about 13,549 (209)

Pharmacokinetic Optimisation of Histamine H1-Receptor Antagonist Therapy

Clinical Pharmacokinetics, 1991
Second-generation, relatively nonsedating histamine H1-receptor antagonists (H1-RA) are extensively used worldwide for the symptomatic treatment of allergic rhinoconjunctivitis and chronic urticaria. Information about the pharmacokinetics and pharmacodynamics of these medications, while still incomplete, is now sufficient to permit optimisation of ...
F. Estelle, R. Simons, Keith J. Simons
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Histamine H1-receptor antagonist activity assessed in conscious dogs

Journal of Pharmacological Methods, 1987
A simple, minimally invasive technique is described which allows assessment of histamine H1-receptor antagonist activity in conscious dogs. The technique is based on the inhibition of the tachycardia caused by intravenous administration of the H1-receptor agonist, 2-pyridylethylamine.
A, Wright, P, Raval, R J, Eden, D A, Owen   +3 more
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Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties

European Journal of Pharmacology, 2005
Diphenylpyraline hydrochloride (DPP) is used clinically as an antihistamine drug, but its neurobiological effects are not completely understood. Voltammetry and microdialysis were used to investigate potential actions of DPP on the dopamine system. Voltammetric monitoring of dopamine signals in mouse nucleus accumbens slices showed that DPP (10 microM)
Gennady B, Lapa, Tiffany A, Mathews, Jill, Harp, Evgeny A, Budygin, Sara R, Jones   +4 more
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[H1 histamine antagonists].

Revue medicale de Bruxelles, 2003
Histamine is an important mediator for early phase allergic reactions that are involved in atopic diseases, mediated by specific IgE antibodies. After allergenic contact, its liberation induces unpleasant symptoms like itching, several manifestations as local vasodilatation, bronchoconstriction, mucus hypersecretion.
J, Duchateau, M, Heenen, J, Sternon
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Clinical comparison of histamine H1–receptor antagonist drugs

Journal of Allergy and Clinical Immunology, 1996
Nearly 40 million Americans have symptoms of upper respiratory allergies, making antihistamines among the most frequently used pharmacologic agents. Although there are mediators of allergic symptoms in addition to histamine, therapy for allergic rhinitis and urticaria has focused upon the use of antihistamines.
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The histamine H1-antagonist chlorpheniramine facilitates learning in aged rats

Neuroscience Letters, 1997
The effect of the histamine H1-receptor antagonist chlorpheniramine on inhibitory avoidance conditioning was investigated in 31-month-old rats, using a one-trial step-through avoidance task. Immediately after the learning trial, old rats were injected intraperitoneally with 5 or 10 mg/kg d-chlorpheniramine.
C, Frisch, R U, Hasenöhrl, J P, Huston
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The H1-histamine antagonist Dithiaden® inhibits human platelets in vitro

Inflammation Research, 1996
Cationic amphiphilic drugs (CAD), including antihistaminics, inhibit platelet aggregation in vitro [1]. We demonstrated recently that Dithiaden® (DIT) antagonised stimulated rat platelets at the level of the arachidonic acid pathway suggesting that phospholipase A2 may be the si te of DIT action [2].
R, Nosál, V, Jancinová, E, Danihelová
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Trifluoperazine inhibits phosphoinositide hydrolysis as a histamine H1-receptor antagonist

European Journal of Pharmacology: Molecular Pharmacology, 1991
In human astrocytoma cells (1321N1), trifluoperazine potently inhibited histamine-induced phosphoinositide hydrolysis, while it slightly inhibited carbachol-induced phosphoinositide hydrolysis. Trifluoperazine as well as diphenhydramine inhibited [3H]mepyramine binding in astrocytoma cell membranes with Ki values of 0.052 microM and 0.005 microM ...
N, Nakahata, H, Ishimoto, A, Takahashi, K, Ohmori, M, Kurita   +4 more
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Nonsedating histamine H1-receptor antagonists.

Clinical pharmacy, 1989
The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosages of the nonsedating histamine H1-receptor antagonists terfenadine, astemizole, loratadine, and acrivastine are reviewed. Terfenadine and astemizole are chemically unrelated to histamine H1-receptor antagonists such as diphenhydramine and chlorpheniramine ...
K V, Mann, J P, Crowe, K J, Tietze
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