Results 161 to 170 of about 13,549 (209)

Determination of some histamine H1-receptor antagonists in dosage forms

Journal of Pharmaceutical and Biomedical Analysis, 2002
Three simple and accurate methods are presented for determination of Cetirizine, Fexofenadine, Loratadine and Acrivastine in pure form and commercial dosage forms. The first method is based on the reaction of the above cited drugs with bromocresol purple dye to form ion-pair complex extractable with chloroform and subsequently measured ...
Azza A, Gazy, Hoda, Mahgoub, F A, El-Yazbi, M A, El-Sayed, Rasha M, Youssef   +4 more
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CNS effects of histamine H₁ antagonists

Clinical & Experimental Allergy, 1999
An accurate evaluation of the functions of the human brain during the administration of drugs is one of the most complex tasks in medical science. In the case of H1 antihistamines, there are many biases that can explain why the interpretation of pharmacological data and those from clinical studies can be very difficult.
J P, Rihoux, F, Donnelly
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Clinical Pharmacology of New Histamiine H1 Receptor Antagonists

Clinical Pharmacokinetics, 1999
The recently introduced H1 receptor antagonists ebastine, fexofenadine and mizolastine, and the relatively new H1 antagonists acrivastine, astemizole, azelastine, cetirizine, levocabastine and loratadine, are diverse in terms of chemical structure and clinical pharmacology, although they have similar efficacy in the treatment of patients with allergic ...
F E, Simons, K J, Simons
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Interactions of Histamine H1-Receptor Agonists and Antagonists with the Human Histamine H4-Receptor

Molecular Pharmacology, 2009
The human histamine H(4)-receptor (hH(4)R) possesses high constitutive activity and, like the human H(1)-receptor (hH(1)R), is involved in the pathogenesis of type-I allergic reactions. The study aims were to explore the value of dual H(1)/H(4)R antagonists as antiallergy drugs and to address the question of whether H(1)R ligands bind to hH(4)R.
Karl-Friedrich, Deml, Silke, Beermann, Detlef, Neumann, Andrea, Strasser, Roland, Seifert   +4 more
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Chemistry of Anti-H1 Histamine Antagonists

1978
In this Chapter a survey and discussion of the chemistry of compounds which antagonize the effects of histamine at H1 receptors are presented. Ellis (1969) has compiled an extensive list of reviews on histamine, 5-hydroxytryptamine, and their antagonists, several of which include some account of the chemical aspects of antihistaminics.
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Inhibition by Cations of Antagonist Binding to Histamine H1-Receptors

1991
The binding of the quaternary radioligand [3H] QMDP to the histamine H1-receptor was inhibited by a series of mono- and di-valent cations. The order of potency was Hg2+ greater than Cd2+ greater than Zn2+ greater than Ni2+ greater than Co2+ greater than Mn2+ greater than Ca2+ greater than Mg2+ greater than Li+ = Na+ greater than K+ greater than Cs ...
J M, Treherne, J S, Stern, W J, Flack, J M, Young   +3 more
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In silico binding characteristics between human histamine H1 receptor and antagonists

Journal of Molecular Modeling, 2010
It is widely acknowledged that the H(1) receptor antagonists have important therapeutic significance in the treatment of various allergic disorders, but little was known about the binding mode between the receptor and antagonists since the crystal structure of G-protein coupling receptors (GPCRs) were hard to obtain.
Xiaojian, Wang, Qian, Yang, Minyong, Li, Dali, Yin, Qidong, You   +4 more
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Pharmacological properties of α-mangostin, a novel histamine H1 receptor antagonist

European Journal of Pharmacology, 1996
In the isolated rabbit thoracic aorta and guinea-pig trachea, alpha-mangostin inhibited histamine-induced contractions in a concentration-dependent manner in the presence or absence of cimetidine, a histamine H2 receptor antagonist. But KCl-, phenylephrine- or carbachol-induced contractions were not affected by alpha-mangostin.
N, Chairungsrilerd, K, Furukawa, T, Ohta, S, Nozoe, Y, Ohizumi   +4 more
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Histamine H1 receptor antagonists

Reactions Weekly, 2009
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Antagonists of H1 Receptors of Histamine: Recent Developments

1991
In the previous handbook of this series on this topic (Casy 1978), attention was drawn to the fact that most compounds known at that time which effectively antagonized histamine at H1-receptor sites could be described by the general structure (1) Open image in new window (1)
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