Results 11 to 20 of about 7,687 (206)
Journal of Pharmacological Sciences, 2005 The second-generation histamine-H1-receptor antagonists, such as epinastine and cetirizine, are used as non-sedating antihistamines for treating allergic symptoms due to their poor ability to penetrate blood-brain barrier.
Junzo Kamei +4 more
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Cetirizine a histamine H1 receptor antagonist improves viral myocarditis [PDF]
Journal of Inflammation, 2010 We showed that mast cells played a critical role in the progression of heart failure induced by pressure overload and viral myocarditis in mice. In this study, we investigated the effect of cetirizine, a selective H1 receptor antagonist, on experimental viral myocarditis induced by encephalomyocarditis (EMC) virus.Four-week-old inbred male DBA/2 mice ...
Yamamoto Kanjo +2 more
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Could Histamine H1 Receptor Antagonists Be Used for Treating COVID-19? [PDF]
International Journal of Molecular Sciences, 2021 COVID-19 has rapidly become a pandemic worldwide, causing extensive and long-term health issues. There is an urgent need to identify therapies that limit SARS-CoV-2 infection and improve the outcome of COVID-19 patients. Unbalanced lung inflammation is a common feature in severe COVID-19 patients; therefore, reducing lung inflammation can undoubtedly ...
Changbo Qu, Gwenny Fuhler, Yihang Pan
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Journal of Pharmacological Sciences, 2014 There is argument whether non-sedative properties of histamine H1–receptor antagonists (antihistamines) are determined by their active extrusions from the brain via P-glycoprotein or their restricted penetration through the blood-brain barrier.
Yoshihiro Uesawa +2 more
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Effects of administration of histamine and its H1, H2, and H3 receptor antagonists into the primary somatosensory cortex on inflammatory pain in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2014 Objective(s): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on ...
Esmaeal Tamaddonfard +1 more
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The developmental toxicity of the H1 histamine antagonists
Reproductive Toxicology, 1996 A, Lione, A R, Scialli
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Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats
Drug Design, Development and Therapy, 2019 Joanna Folwarczna, Natalia Konarek, Karolina Freier, Dawid Karbowniczek, Piotr Londzin, Aleksandra Janas Department of Pharmacology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice ...
Folwarczna J +5 more
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Journal of Pharmacological Sciences, 2008 We evaluated changes in the binding properties of sedative and non-sedative histamine H1–receptor antagonists induced by internalization of H1 receptors in intact human U373 MG astrocytoma cells.
Shigeru Hishinuma +4 more
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Histamine antagonists promote cancer immunosurveillance
OncoImmunology, 2023 Recently, a cellular mini-immune system comprising infinitely expandable dendritic cells and T cells led to the discovery that histamine receptor H1 antagonists act on T cells to stimulate their proliferation and polarization toward a Th1/Tc1 phenotype ...
Peng Liu, Guido Kroemer, Oliver Kepp
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Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns
Frontiers in Endocrinology, 2023 Severe burns induce a catecholamine surge, causing severe damage to the organism and raising the possibility of multisystem organ failure. Few strategies are generally acceptable to reduce catecholamine surge and organ injury post-burn.
Jizhuang Wang +8 more
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