The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions
Frontiers in Pharmacology, 2021 This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart.
Joachim Neumann +4 more
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Cetirizine a histamine H1 receptor antagonist improves viral myocarditis [PDF]
Journal of Inflammation, 2010 We showed that mast cells played a critical role in the progression of heart failure induced by pressure overload and viral myocarditis in mice. In this study, we investigated the effect of cetirizine, a selective H1 receptor antagonist, on experimental viral myocarditis induced by encephalomyocarditis (EMC) virus.Four-week-old inbred male DBA/2 mice ...
Kanjo Yamamoto +2 more
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Histamine antagonists promote cancer immunosurveillance
OncoImmunology, 2023 Recently, a cellular mini-immune system comprising infinitely expandable dendritic cells and T cells led to the discovery that histamine receptor H1 antagonists act on T cells to stimulate their proliferation and polarization toward a Th1/Tc1 phenotype ...
Peng Liu, Guido Kroemer, Oliver Kepp
doaj +1 more source
Histamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]
, 2019 Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [75, 163]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [75]. The human and rat
Chazot, Paul +19 more
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Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns
Frontiers in Endocrinology, 2023 Severe burns induce a catecholamine surge, causing severe damage to the organism and raising the possibility of multisystem organ failure. Few strategies are generally acceptable to reduce catecholamine surge and organ injury post-burn.
Jizhuang Wang +8 more
doaj +1 more source
Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands [PDF]
, 2019 In this study, we report a ligand-guided homology modeling approach allowing the analysis of relevant binding site residue conformations and the identification of two novel histamine H3 receptor ligands with binding affinity in the nanomolar range.
Hagenow, Stefanie +3 more
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Performance studies with the H1‐histamine receptor antagonists, astemizole and terfenadine. [PDF]
British Journal of Clinical Pharmacology, 1982 1 Effects of the antihistamines, terfenadine (60 mg) and astemizole (10 and 20 mg), on performance (visuo‐motor coordination, arithmetical ability and digit symbol substitution) and on mood were studied in six healthy adult females. The study was double‐blind, placebo controlled and included an antihistamine with known central effects (triprolidine 10 ...
AN Nicholson, BM Stone
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Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]
, 2017 The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
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Pharmacophore Modeling of N1-alkyltheobromine as Histamine-H1 Receptor Antagonist [PDF]
International Journal of Modeling and Optimization, 2015 Maywan Hariono, Habibah A. Wahab
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ACSEE: Antagonistic Crowd Simulation Model with Emotional Contagion and Evolutionary Game Theory [PDF]
IEEE Transactions on Affective Computing (2019), 2019 Antagonistic crowd behaviors are often observed in cases of serious conflict. Antagonistic emotions, which is the typical psychological state of agents in different roles (i.e. cops, activists, and civilians) in crowd violent scenes, and the way they spread through contagion in a crowd are important causes of crowd antagonistic behaviors.
arxiv +1 more source