Results 81 to 90 of about 19,031 (233)

Mast Cells May Differentially Regulate Growth of Lymphoid Neoplasms by Opposite Modulation of Histamine Receptors

open access: yesFrontiers in Oncology, 2019
Cancer microenvironment is complex and consists of various immune cells. There is evidence for mast cell (MC) infiltration of tumors, but their role thereof is poorly understood.
Sandeep Paudel   +2 more
doaj   +1 more source

Molecular Regulation of Histamine Synthesis [PDF]

open access: yesarXiv, 2018
Histamine is a critical mediator of IgE/ cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine.
arxiv  

Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]

open access: yesWorld Journal of Research and Review (WJRR) ISSN:2455-3956, Volume-4, Issue-5, May 2017 Pages 26-30, 2020
Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv  

Comparative Evaluation of the Hemodynamic Effects of Oral Cimetidine, Ranitidine, and Famotidine as Determined by Echocardiography [PDF]

open access: yes, 1995
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90052/1/j.1875-9114.1995.tb04349.x ...
Berardi, Rosemary R.   +5 more
core   +1 more source

Impact of Exposure to Benzodiazepines on Adverse Effects and Efficacy of PD‐1/PD‐L1 Blockade in Patients With Non‐Small Cell Lung Cancer

open access: yesThoracic Cancer, Volume 16, Issue 9, May 2025.
The use of benzodiazepine receptor agonists (BZRAs) was linked to a reduced incidence of irAEs in patients with NSCLC receiving anti‐PD‐1/PD‐L1 monotherapy. However, among those who developed irAEs, BZRA use was associated with shorter PFS and OS. These findings suggest that while BZRAs may lower the incidence of irAEs, they could also diminish the ...
Kiyoshi Takagaki   +5 more
wiley   +1 more source

Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study

open access: yesSão Paulo Medical Journal
: CONTEXT AND OBJECTIVE: The prevalence of vitamin B12 deficiency varies from 5.8% to 30% among patients undergoing long-term treatment with metformin. Because of the paucity of data on Brazilian patients, this study aimed to determine the frequency of
Charbel Pereira Damião   +6 more
doaj   +1 more source

Coordination on Time-Varying Antagonistic Networks [PDF]

open access: yesarXiv, 2021
This paper studies coordination problem for time-varying networks suffering from antagonistic information, quantified by scaling parameters. By such a manner, interacting property of the participating individuals and antagonistic information can be quantified in a fully decoupled perspective, thus benefiting from merely directed spanning tree ...
arxiv  

Effect of an antiandrogenic H2 receptor antagonist on hepatic regeneration in rats [PDF]

open access: yes, 1988
Because biochemical 'feminization' of the liver in males is observed with hepatic regeneration and because the hepatic regenerative response in females is greater than that in males, the posibility that antiandrogens might potentiate liver regeneration ...
Chapchap, P   +7 more
core  

Novel sulfonylurea derivatives as H3 receptor antagonists. Preliminary SAR studies [PDF]

open access: yes, 2012
The combination of antagonism at histamine H3 receptor and the stimulation of insulin secretion have been proposed as an approach to new dual therapeutic agents for the treatment of type 2 diabetes mellitus associated with obesity.
Aldana, I. (Ignacio)   +5 more
core   +1 more source

High Throughput Pharmacovigilance Screening for Roflumilast Adverse Effects in Real‐World Settings: A Sequence Symmetry Analysis

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Background Roflumilast is an add‐on therapy for COPD following exacerbations, but real‐world safety data in the United States are limited. Objective This study aimed to identify safety signals associated with roflumilast initiation through a high‐throughput signal detection algorithm. Methods Using sequence symmetry analysis (SSA), we analysed
Abdullah Abdelaziz   +3 more
wiley   +1 more source

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