Acute and subchronic effects of the H1‐histamine receptor antagonist ebastine in 10, 20 and 30 mg dose, and triprolidine 10 mg on car driving performance. [PDF]
K A Brookhuis, G de Vries, Dick de Waard
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MRI‐based surrogates of brain clearance in narcolepsy type 1
Summary Brain clearance involves the drainage of waste molecules from the brain, a process that is suggested to be amplified during sleep. Recently proposed MRI‐based methods attempt to approximate human brain clearance with surrogate measures. The current study aimed to explore whether two brain clearance surrogates are altered in narcolepsy.
Eva M. van Heese+6 more
wiley +1 more source
Mast Cells May Differentially Regulate Growth of Lymphoid Neoplasms by Opposite Modulation of Histamine Receptors. [PDF]
Paudel S, Mehtani D, Puri N.
europepmc +1 more source
Novel histamine H3 receptor antagonists: affinities in an H3 receptor binding assay and potencies in two functional H3 receptor models [PDF]
Eberhard Schlicker+4 more
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Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy
ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash+5 more
wiley +1 more source
Research Advances and Prospects on Mechanism of Sinomenin on Histamine Release and the Binding to Histamine Receptors. [PDF]
Zhang YS, Han JY, Iqbal O, Liang AH.
europepmc +1 more source
In vitro studies with GI surgical specimens or biopsy are a critical step in translating preclinical studies in animals to humans before testing potential therapeutic interventions in expensive clinical trials. Routine availability of human gut specimens, in combination with technological advances and powerful new in vitro models of the human ENS from ...
Dmitrii Pavlov, Fievos L. Christofi
wiley +1 more source
Cudrania tricuspidata Extract Protects against Reflux Esophagitis by Blocking H2 Histamine Receptors. [PDF]
Kim JY+4 more
europepmc +1 more source
Tiotidine, a new long-acting histamine H2-receptor antagonist: Comparison with cimetidine
Charles T. Richardson+3 more
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Defective lymphatic vasculature in obesity
Summary Lymphedema is an important, and often underdiagnosed complication of obesity and is likely due to acquired defects in the lymphatic vasculature. Study of diet‐induced obesity animal models have indicated defective lymphatic vasculatures might extend to other anatomical sites, especially visceral depots.
Jingjing Zhu, John P. H. Wilding, Ji Hu
wiley +1 more source