Results 41 to 50 of about 58,945 (147)

Histamine stimulates human microglia to alter cellular prion protein expression via the HRH2 histamine receptor

Scientific Reports
Although the cellular prion protein (PrPC) has been evolutionarily conserved, the role of this protein remains elusive. Recent evidence indicates that PrPC may be involved in neuroinflammation and the immune response in the brain, and its expression may ...
Marcus Pehar, Melissa Hewitt, Ashley Wagner, Jagdeep K. Sandhu, Aria Khalili, Xinyu Wang, Jae-Young Cho, Valerie L. Sim, Marianna Kulka   +8 more
doaj   +1 more source

Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation.

PLoS ONE, 2012
IntroductionChronic mast cell activation is a characteristic feature of asthma. BEAS-2B human airway epithelial cells (AEC) profoundly inhibit both constitutive and IgE-dependent human lung mast cell (HLMC) histamine release. The aim of this study was to
Neil Martin, Andrew Ruddick, Greer K Arthur, Heidi Wan, Lucy Woodman, Christopher E Brightling, Don J L Jones, Ian D Pavord, Peter Bradding   +8 more
doaj   +1 more source

IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

Mediators of Inflammation, 1998
The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is
U. Westin, E. Lundberg, K. Ohlsson
doaj   +1 more source

Synthesis of Gallic Acid Analogs as Histamine and Pro-Inflammatory Cytokine Inhibitors for Treatment of Mast Cell-Mediated Allergic Inflammation

Molecules, 2017
Gallic acid (3,4,5-trihydroxybenzoic acid), is a natural product found in various foods and herbs that are well known as powerful antioxidants. Our previous report demonstrated that it inhibits mast cell-derived inflammatory allergic reactions by ...
Xiang Fei, In-Gyu Je, Tae-Yong Shin, Sang-Hyun Kim, Seung-Yong Seo   +4 more
doaj   +1 more source

Different hypersensitivities against homologous proteins of MGL_1304 in patients with atopic dermatitis

Allergology International, 2018
Background: Atopic dermatitis (AD) is exacerbated by sweating, and the skin of most patients with AD are resided by Malassezia (M.) fungi. Recently, MGL_1304 produced by Malassezia globosa was identified as the major histamine releasing antigen in human ...
Takuma Kohsaka, Takaaki Hiragun, Kaori Ishii, Makiko Hiragun, Akiko Kamegashira, Michihiro Hide   +5 more
doaj   +1 more source

Effects of histamine on human periodontal ligament fibroblasts under simulated orthodontic pressure.

PLoS ONE, 2020
As type-I-allergies show an increasing prevalence in the general populace, orthodontic patients may also be affected by histamine release during treatment.
Marcella Groeger, Gerrit Spanier, Michael Wolf, James Deschner, Peter Proff, Agnes Schröder, Christian Kirschneck   +6 more
doaj   +1 more source

Nigella sativa as an anti-inflammatory agent in asthma

BMC Research Notes, 2018
Objective Nigella sativa (N. sativa) has several pharmacological actions which include antioxidant, antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, and bronchodilator.
Mukhtar Ikhsan, Nurul Hiedayati, Kazutaka Maeyama, Fariz Nurwidya   +3 more
doaj   +1 more source

Interleukin-4 (IL-4) enhances and soluble interleukin-4 receptor (sIL-4R) inhibits histamine release from peripheral blood basophils and mast cells in vitro and in vivo

Mediators of Inflammation, 1997
The aim of the study was to analyse the effect of interleukin-4 (IL-4) on allergen and anti-IgE mediated histamine release from basophils and human skin mast cells and to assess whether soluble recombinant interleukin-4 receptor (sIL4R) can inhibit these
B. Niggemann, T. Zuberbier, U. Herz, K. Enssle, U. Wahn, H. Renz   +5 more
doaj   +1 more source

Stabilizing histamine release in gut mast cells mitigates peripheral and central inflammation after stroke. [PDF]

J Neuroinflammation, 2023
Conesa MPB, Blixt FW, Peesh P, Khan R, Korf J, Lee J, Jagadeesan G, Andersohn A, Das TK, Tan C, Di Gesu C, Colpo GD, Moruno-Manchón JF, McCullough LD, Bryan R, Ganesh BP.   +15 more
europepmc   +1 more source

IgE clonality and aggregation of insulin affect IgE-mediated activation of sensitized basophils

Journal of Allergy and Clinical Immunology: Global
Background: Skin prick testing and specific IgE determination do not discriminate between sensitization and clinically relevant insulin allergic reactions, whereas the basophil histamine release assay has proven useful in identifying clinically relevant ...
Steffen Christoffersen, MSc, Katrine Baumann, PhD, Anders Holm Millner, PhD, Henrik Toft-Hansen, PhD, Eva Johansson, PhD, Camilla Thorlaksen, PhD, Per Stahl Skov, PhD   +6 more
doaj   +1 more source