Results 181 to 190 of about 135,178 (348)

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16

The FEBS Journal, EarlyView.
To investigate the impact of dietary components on animal growth, an Escherichia coli single‐gene deletion library was screened using the Caenorhabditis elegans growth model. Thirty‐four E. coli mutants were identified to delay worm development. Notably, E.
Min Feng, Baizhen Gao, L. Rene Garcia, Qing Sun   +3 more
wiley   +1 more source

Brain pyridoxal kinase. Purification, substrate specificities, and sensitized photodestruction of an essential histidine.

, 1979
Francis Kwok, Jorge E. Churchich
openalex   +1 more source

The Role of Histidines in the Acetate Kinase fromMethanosarcina thermophila [PDF]

, 2000
Cheryl Ingram‐Smith, Robert D. Barber, James G. Ferry   +2 more
openalex   +1 more source

Effect of histidine protonation state on ligand binding at the ATP-binding site of human protein kinase CK2

Scientific Reports
Histidine residues contribute to numerous molecular interactions, owing to their structure with the ionizable aromatic side chain with pKa close to the physiological pH.
Maria Winiewska-Szajewska, Daniel Paprocki, Ewa Marzec, Jarosław Poznański   +3 more
doaj   +1 more source

Molecular mechanisms of hotspot variants in cytoskeletal β‐actin associated with Baraitser–Winter syndrome

The FEBS Journal, EarlyView.
Variants at position R196 in cytoskeletal β‐actin are the most common variants associated with Baraitser–Winter cerebrofrontofacial syndrome and result in craniofacial anomalies and neurodevelopmental disorders, most likely due to neuronal migration defects. This study explores the molecular mechanisms of p.R196 variants using purified proteins.
Johannes N. Greve, Dietmar J. Manstein
wiley   +1 more source

The LytS-type histidine kinase BtsS is a 7-transmembrane receptor that binds pyruvate. [PDF]

mBio, 2023
Qiu J, Gasperotti A, Sisattana N, Zacharias M, Jung K.   +4 more
europepmc   +1 more source

A Bacterial Receptor PcrK Senses the Plant Hormone Cytokinin to Promote Adaptation to Oxidative Stress

Cell Reports, 2017
Summary: Recognition of the host plant is a prerequisite for infection by pathogenic bacteria. However, how bacterial cells sense plant-derived stimuli, especially chemicals that function in regulating plant development, remains completely unknown. Here,
Fang-Fang Wang, Shou-Ting Cheng, Yao Wu, Bao-Zhen Ren, Wei Qian   +4 more
doaj  

Circulating Mast Cell Progenitors Are Depleted by Benralizumab in Severe Asthma

Allergy, EarlyView.
Michael Fricker, John Harrington, Sarah A. Hiles, Peter G. Gibson   +3 more
wiley   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

SAGEPhos: Sage Bio-Coupled and Augmented Fusion for Phosphorylation Site Detection [PDF]

arXiv
Phosphorylation site prediction based on kinase-substrate interaction plays a vital role in understanding cellular signaling pathways and disease mechanisms. Computational methods for this task can be categorized into kinase-family-focused and individual kinase-targeted approaches.
arxiv