Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer +11 more
wiley +1 more source
The unique histidine kinase, AtcS, regulates motility and pathogenicity of the periodontal pathobiont, <i>Treponema denticola</i>. [PDF]
Abdallah DN +6 more
europepmc +1 more source
Auxin-Producing Pseudomonas Recruited by Root Flavonoids Increases Rice Rhizosheath Formation through the Bacterial Histidine Kinase Under Soil Drying. [PDF]
Xu F +23 more
europepmc +1 more source
Human neutrophil defensin-1 binding increases histidine kinase activity of SaeS in <i>Staphylococcus aureus</i>. [PDF]
Qi Z +8 more
europepmc +1 more source
Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs. [PDF]
Brüderlin M +5 more
europepmc +1 more source
The Treponema denticola PAS Domain-Containing Histidine Kinase Hpk2 Is a Heme Binding Sensor of Oxygen Levels [PDF]
Juni Sarkar +3 more
openalex +1 more source
The role of fibroblast growth factors in cell and cancer metabolism
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source

