A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen. [PDF]
Microb Pathog, 2023 Chaves-Olarte E +15 more
europepmc +1 more source
Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock
The FEBS Journal, EarlyView.Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány +6 more
wiley +1 more source
Constitutive competence for genetic transformation in Streptococcus pneumoniae caused by mutation of a transmembrane histidine kinase [PDF]
, 2001 Sanford A. Lacks, Bill Greenberg
openalex +1 more source
The FEBS Journal, EarlyView.Regions flanking the PCNA‐binding motif in p21 contribute to high‐affinity binding through complementary charges without specific contacts. These regions affect p21 abundance, but their exact Lys/Arg composition is unimportant for PCNA binding. Conversely, both context and Lys/Arg composition of the N‐terminal flanking region are crucial for p21 ...
Signe Simonsen +8 more
wiley +1 more source
Structural and Mutational Analysis of the PhoQ Histidine Kinase Catalytic Domain [PDF]
, 2001 Alberto Marina +4 more
openalex +1 more source
The FEBS Journal, EarlyView.TENT5C is a suppressor of ERα and GR transcriptional activation. A specific LXXLL motif in TENT5C, absent in the other members of the TENT5 subfamily, mediates a stable interaction with the Ligand Binding Domain of ERα but not with that of GR.
Yin Li +5 more
wiley +1 more source
Characterization of the Catalytic Activities of the PhoQ Histidine Protein Kinase of Salmonella enterica Serovar Typhimurium [PDF]
, 2001 Martin Montagne +2 more
openalex +1 more source
Integration of Genetic Algorithms and Deep Learning for the Generation and Bioactivity Prediction of Novel Tyrosine Kinase Inhibitors [PDF]
arXivThe intersection of artificial intelligence and bioinformatics has enabled significant advancements in drug discovery, particularly through the application of machine learning models. In this study, we present a combined approach using genetic algorithms and deep learning models to address two critical aspects of drug discovery: the generation of novel
arxiv
Osmotic Stress Responses, Cell Wall Integrity, and Conidiation Are Regulated by a Histidine Kinase Sensor in Trichoderma atroviride. [PDF]
J Fungi (Basel), 2023 Calcáneo-Hernández G +4 more
europepmc +1 more source