Results 211 to 220 of about 82,686 (281)

Histidine kinase-mediated cross-regulation of the vancomycin-resistance operon in Clostridioides difficile. [PDF]

Mol Microbiol
Belitsky BR.
europepmc   +1 more source

Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid

ChemistryEurope, Volume 4, Issue 1, January 2026.
Amyloid‐selective catalytic photooxygenation reduces amyloid toxicity, aggregation tendencies, and seeding activities. Achieving therapeutic catalysis for intracellular amyloids is challenging due to conflicting oxygenation and reductive cellular environments.
Atsushi Iwai, Youhi Hwang, Hiroki Umeda, Taka Sawazaki, Ikumi Tomizawa, Maiko Ono, Makoto Higuchi, Youhei Sohma, Yukiko Hori, Taisuke Tomita, Harunobu Mitsunuma, Motomu Kanai   +11 more
wiley   +1 more source

Mapping of PTP1B, TCPTP, SHP2, and Putative Substrates Reveals Novel Networks in Glomerular Podocytes

Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.
Abstract Preservation of the insulin‐sensitive glomerular podocyte is imperative for normal kidney function. The protein tyrosine phosphatases (PTPs), protein tyrosine phosphatase 1B (PTP1B), T‐cell protein tyrosine phosphatase (TCPTP), and Src homology phosphatase 2 (SHP2) are established regulators of insulin signaling in vivo and implicated in renal
Grace LeBleu, Ming‐Fo Hsu, Yoshihiro Ito, Suh‐Yuen Liang, Kwan‐Liu Ma, Tzu‐Ching Meng, Fawaz G. Haj   +6 more
wiley   +1 more source

PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer. [PDF]

EMBO J
Wang Y, Shu H, Qu Y, Jin X, Liu J, Peng W, Wang L, Hao M, Xia M, Zhao Z, Dong K, Di Y, Tian M, Hao F, Xia C, Zhang W, Ba X, Feng Y, Wei M.   +18 more
europepmc   +1 more source

Visualizing Evolutionary Relationships of Multidomain Proteins: An Example from Receiver (REC) Domains of Sensor Histidine Kinases in the Candidatus Maribeggiatoa str. Orange Guaymas Draft Genome

, 2020
Barbara J. MacGregor
openalex   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 69-106, January/February 2026.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Chemotaxis and phototaxis require a CheA histidine kinase in the archaeon Halobacterium salinarium.

, 1995
Johannes Rudolph, Dieter Oesterhelt
openalex   +2 more sources

Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity

Obesity, Volume 34, Issue 1, Page 127-137, January 2026.
ABSTRACT Objective Severe obesity poses a major public health concern due to its links with cardiometabolic complications and mortality. Visceral adipose tissue (VAT) plays a key role in these processes through distinct molecular features. This study aimed to characterize the VAT proteome of individuals with severe obesity and investigate its ...
Prince Dadson, Miikka‐Juhani Honka, Tomi Suomi, Anne Rokka, Saila Kauhanen, Paulina Salminen, Mika Helmiö, Peter James, Laura L. Elo, Vesa M. Olkkonen, Pirjo Nuutila   +10 more
wiley   +1 more source

An open axial channel of the AAA ClpXP protease enhances degradation of specific classes of protein substrates

Protein Science, Volume 35, Issue 1, January 2026.
Abstract ClpXP and other AAA proteases maintain proteostasis and regulate cellular functions by degrading misfolded, incomplete, or regulatory proteins. ClpX recognizes substrates via unstructured degron sequences, typically located at the N‐ or C‐terminus. Although five classes of degrons are known, only recognition of the ssrA tag, a C‐motif‐1 degron,
Yifei Lyu, Isabella Bolstad, Joseph H. Davis, Robert T. Sauer, Alireza Ghanbarpour   +4 more
wiley   +1 more source

Low-Cost Communication: Allosteric Activation Pathway in Histidine-Kinases

Juan Cruz Almada, Ana Bortolotti, Lucía Porrini, Daniela Albanesi, Virginia Miguel, Larisa E. Cybulski   +5 more
openalex   +1 more source