Results 41 to 50 of about 135,178 (348)
Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B. [PDF]
, 2015 UnlabelledNitric oxide (NO) plays an important signaling role in all domains of life. Many bacteria contain a heme-nitric oxide/oxygen binding (H-NOX) protein that selectively binds NO.
Marletta, Michael A +2 more
core +3 more sources
Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]
, 2008 Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad +4 more
core +1 more source
The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis [PDF]
, 2020 International ...
Boissan, Mathieu +6 more
core +4 more sources
mBio, 2015 HAMP domains are α-helical coiled coils that often transduce signals from extracytoplasmic sensing domains to cytoplasmic domains. Limited structural information has resulted in hypotheses that specific HAMP helix movement changes downstream enzymatic ...
Susana Matamouros +2 more
doaj +1 more source
Inferring interaction partners from protein sequences [PDF]
Proc. Natl. Acad. Sci. U.S.A., 113(43): 12180-12185 (2016), 2016 Specific protein-protein interactions are crucial in the cell, both to ensure the formation and stability of multi-protein complexes, and to enable signal transduction in various pathways. Functional interactions between proteins result in coevolution between the interaction partners, causing their sequences to be correlated.
arxiv +1 more source
NM23-H1: a Metastasis-Associated Gene
Taiwanese Journal of Obstetrics & Gynecology, 2006 The protein product of nm23-H1 gene has activity of nucleoside diphosphate (NDP) kinase, which catalyzes the phosphorylation of nucleoside diphosphates to the corresponding nucleoside triphosphates.
Yi-Torng Tee +4 more
doaj +1 more source
Proton transfer in histidine-tryptophan heterodimers embedded in helium droplets [PDF]
Journal of Chemical Physics 142, 114306 (2015), 2015 We used cold helium droplets as nano-scale reactors to form and ionize, by electron bombardment and charge transfer, aromatic amino acid heterodimers of histidine with tryptophan, methyl-tryptophan, and indole. The molecular interaction occurring through an N-H...N hydrogen bond leads to a proton transfer from the indole group of tryptophan to the ...
arxiv +1 more source
Frontiers in Pharmacology, 2015 Reversible phosphorylation of amino acid side chains in proteins is a frequently used mechanism in cellular signal transduction and alterations of such phosphorylation patterns are very common in cardiovascular diseases.
Thomas Wieland, Paul V. Attwood
doaj +1 more source
Characterization of CHARK, an unusual cytokinin receptor of rice
Scientific Reports, 2021 The signal transduction of the plant hormone cytokinin is mediated by a His-to-Asp phosphorelay. The canonical cytokinin receptor consists of an extra cytoplasmic hormone binding domain named cyclase/histidine kinase associated sensory extracellular ...
Mhyeddeen Halawa +3 more
doaj +1 more source
Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1 [PDF]
, 2009 Background. In Xenopus retinogenesis, p27Xic1, a Xenopus cyclin dependent kinase inhibitor, functions as a cell fate determinant in both gliogenesis and neurogenesis in a context dependent manner.
Aikaterini Bilitou +6 more
core +3 more sources