Results 41 to 50 of about 82,686 (281)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A novel insight into ComE-mediated activation of gene expression in Streptococcus mutans
Microbiology SpectrumBacteria use two-component signal transduction systems (TCSs) to sense and respond to environmental changes. TCSs comprise a histidine kinase that senses environmental signals and a response regulator that regulates cognate promoters.
Hemendra Pal Singh Dhaked +2 more
doaj +1 more source
Mechanism of Regulation of Receptor Histidine Kinases [PDF]
Structure, 2012 Bacterial transmembrane receptors regulate an intracellular catalytic output in response to extracellular sensory input. To investigate the conformational changes that relay the regulatory signal, we have studied the HAMP domain, a ubiquitous intracellular module connecting input to output domains.
Ferris, Hedda U. +8 more
openaire +4 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Phytochrome: If It Looks and Smells Like a Histidine Kinase, Is It a Histidine Kinase? [PDF]
Cell, 1997 That's all fine and good for cyanobacterial phytochrome, but the real excitement has to do with potential functional homology of plant phytochromes. Specifically, do plant phytochromes possess histidine kinase activity and what then do we make of phytochrome-associated serine kinase activity? As discussed by Quail 1997xQuail, P.H. BioEssay.
Elich, Tedd D, Chory, Joanne
openaire +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Molecular Plant-Microbe Interactions, 1997 A mutant of Erwinia carotovora subsp. carotovora, AH2552, created by a Mud1 insertion was found to be reduced in plant pathogenicity and deficient in extracellular protease and cellulase activity, although it produced normal levels of pectate lyase and ...
Reid D. Frederick +3 more
doaj +1 more source
Dimer Asymmetry and Light Activation Mechanism in Brucella Blue-Light Sensor Histidine Kinase
mBio, 2021 Bacteria employ two-component systems (TCSs) to sense and respond to changes in their surroundings. At the core of the TCS signaling pathway is the multidomain sensor histidine kinase, where the enzymatic activity of its output domain is allosterically ...
Jimena Rinaldi +13 more
doaj +1 more source
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source