Results 61 to 70 of about 135,178 (348)

Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes [PDF]

Genome Biology and Evolution, 2018
Histidine kinases (HKs) are primary sensor proteins that act in cell signaling pathways generically referred to as "two-component systems" (TCSs). TCSs are among the most widely distributed transduction systems used by both prokaryotic and eukaryotic organisms to detect and respond to a broad range of environmental cues.
Kabbara, Samar, Hérivaux, Anaïs, Dugé de Bernonville, Thomas, Courdavault, Vincent, Clastre, Marc, Gastebois, Amandine, Osman, Marwan, Hamze, Monzer, Cock, J. Mark, Schaap, Pauline, Papon, Nicolas   +10 more
openaire   +6 more sources

β-Catenin is a pH sensor with decreased stability at higher intracellular pH. [PDF]

, 2018
β-Catenin functions as an adherens junction protein for cell-cell adhesion and as a signaling protein. β-catenin function is dependent on its stability, which is regulated by protein-protein interactions that stabilize β-catenin or target it for ...
Aberle, Baumgartner, Bree K. Grillo-Hill, Chairoungdua, Choi, Choi, Cold Spring Harbor Protocols, Dai, Daugherty, Denker, Denker, Diane L. Barber, Endo, Forbes, Forbes, Frantz, Frescas, Grillo-Hill, Ha, Hart, Ismahan Chire, Jobelle Peralta, Katharine A. White, Klaus, Krausova, Lee, Li, Liu, Liu, Mario Esquivel, Megy, Morin, Pai, Parks, Peifer, Peifer, Petherick, Pronobis, Reim, Reshkin, Sadot, Sahai-Hernandez, Schönichen, Sedgwick, Shafique, Simons, Stamos, Stehbens, Ulmschneider, Valenta, Vivian N. Bui, Waghmare, Webb, White, White, Wolff, Wu   +56 more
core   +1 more source

Mechanism of transmembrane signaling by sensor histidine kinases [PDF]

Science, 2017
Bacterial sensing mechanism revealed Escherichia coli use a transmembrane sensor protein to sense nitrate in their external environment and initiate a biochemical response. Gushchin et al. compared crystal structures of portions of the NarQ receptor that included the transmembrane helices in ...
Valentin Gordeliy, Valentin Gordeliy, Ivan Gushchin, Andrii Ishchenko, Gordon A. Leonard, Taras Balandin, Pavel Buslaev, Anastasia Yuzhakova, Ekaterina Round, Gleb Bourenkov, Georg Büldt, Alexander Popov, Valentin Borshchevskiy, Dieter Willbold, Igor Melnikov, Sergei Grudinin, Sergei Grudinin, Sergei Grudinin, Vitaly Polovinkin, Vitaly Polovinkin   +19 more
openaire   +5 more sources

Identification of possible Ser/Thr/Tyr phosphorylation sites in the fungal histidine kinase CaNik1p by peptide array technique

Bulletin of Faculty of Pharmacy Cairo University, 2018
CaNik1p is a histidine kinase (HK) that is present in Candida albicans. It was found to be a target for antifungal activities on the hyperosmotic glycerol pathway.
Mohammed El-Mowafy, Ursula Bilitewski
doaj   +1 more source

Transposon and deletion mutagenesis of genes involved in perchlorate reduction in Azospira suillum PS. [PDF]

, 2013
UnlabelledAlthough much work on the biochemistry of the key enzymes of bacterial perchlorate reduction, chlorite dismutase, and perchlorate reductase has been published, understanding of the molecular mechanisms of this metabolism has been somewhat ...
Clark, Iain C, Coates, John D, Liao, Annette, Melnyk, Ryan A   +3 more
core   +2 more sources

Stable Radical Polymers as New Electroactive Materials: Synthesis, Properties, and Emerging Applications

Advanced Functional Materials, EarlyView.
This review covers the recent advances in the synthesis and properties of stable radical polymers (SRPs) and presents their applications in electronics, magnetics, optoelectronics, and biomedicines. The review concludes with a discussion of the challenges in radical chemistry and functionalization, while shedding light on the groundbreaking potential ...
Yufeng Xiong, Yingjiang Li, Xinfang Cui, Shiwei Li, Xiangdong Peng, Yanyun Ju, Tong Zhou, Rui Feng, Yang Zhang, Zehong Wang, Qing Wang, Lijie Dong   +11 more
wiley   +1 more source

Structural insights into characterizing binding sites in EGFR kinase mutants [PDF]

Journal of Chemical Information and Modeling, 2018, 2018
Over the last two decades epidermal growth factor receptor (EGFR) kinase has become an important target to treat non-small cell lung cancer (NSCLC). Currently, three generations of EGFR kinase-targeted small molecule drugs have been FDA approved. They nominally produce a response at the start of treatment and lead to a substantial survival benefit for ...
arxiv   +1 more source

Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation [PDF]

, 2017
This work was funded by the UK Biotechnology and Biological Research Council [www.bbsrc.ac.uk] JQ (BB/K016393/1); AJPB (BB/K017365/1). The work was also supported by the Wellcome Trust [www.wellcome.ac.uk], JQ (086048, 097377); AJPB (097377)); LPE ...
Brown, Alistair J P, Day, Alison M, Erwig, Lars P, Haider, Mohammed, Herrero De Dios, Carmen M, Ikeh, Mélanie A C, MacCallum, Donna M, Morgan, Brian A, Quinn, Janet, Smith, Deborah A   +9 more
core   +3 more sources

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Inferring the Sign of Kinase-Substrate Interactions by Combining Quantitative Phosphoproteomics with a Literature-Based Mammalian Kinome Network [PDF]

, 2010
Protein phosphorylation is a reversible post-translational modification commonly used by cell signaling networks to transmit information about the extracellular environment into intracellular organelles for the regulation of the activity and sorting of proteins within the cell.
arxiv   +1 more source