Two-component histidine kinase DRK1 is required for pathogenesis in Sporothrix schenckii
Molecular Medicine Reports, 2017 Sporothrix schenckii is a pathogenic dimorphic fungus with a global distribution. It grows in a multicellular hyphal form at 25°C and a unicellular yeast form at 37°C.
Zhen-ying Zhang +5 more
semanticscholar +1 more source
Hybrid histidine kinases in pathogenic fungi [PDF]
Molecular Microbiology, 2015 SummaryHistidine kinases (HK) sense and transduce via phosphorylation events many intra‐ and extracellular signals in bacteria, archaea, slime moulds and plants. HK are also widespread in the fungal kingdom, but their precise roles in the regulation of physiological processes remain largely obscure.
Defosse, Tatiana +9 more
openaire +3 more sources
Modification of histidine repeat proteins by inorganic polyphosphate
Cell Reports, 2023 Summary: Inorganic polyphosphate (polyP) is a linear polymer of orthophosphate that is present in nearly all organisms studied to date. A remarkable function of polyP involves its attachment to lysine residues via non-enzymatic post-translational ...
Nolan Neville +6 more
doaj +1 more source
Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation [PDF]
, 2017 This work was funded by the UK Biotechnology and Biological Research Council [www.bbsrc.ac.uk] JQ (BB/K016393/1); AJPB (BB/K017365/1). The work was also supported by the Wellcome Trust [www.wellcome.ac.uk], JQ (086048, 097377); AJPB (097377)); LPE ...
Brown, Alistair J P +9 more
core +3 more sources
Conformational dynamics of the essential sensor histidine kinase WalK
Acta Crystallographica Section D: Structural Biology, 2017 The different conformations of WalK reveal the intrinsic dynamic properties of a sensor histidine kinase structure as a molecular basis for multifunctionality.
Yongfei Cai +9 more
semanticscholar +1 more source
Functional characterization of the diatom cyclin-dependent kinase A2 as a mitotic regulator reveals plant-like properties in a non-green lineage [PDF]
, 2015 Background: Cyclin-dependent kinases (CDKs) are crucial regulators of cell cycle progression in eukaryotes. The diatom CDKA2 was originally assigned to the classical A-type CDKs, but its cell cycle phase-specific transcription at the G2-to-M phase ...
Bowler, Chris +4 more
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A novel insight into ComE-mediated activation of gene expression in Streptococcus mutans
Microbiology SpectrumBacteria use two-component signal transduction systems (TCSs) to sense and respond to environmental changes. TCSs comprise a histidine kinase that senses environmental signals and a response regulator that regulates cognate promoters.
Hemendra Pal Singh Dhaked +2 more
doaj +1 more source
Bulletin of Faculty of Pharmacy Cairo University, 2018 CaNik1p is a histidine kinase (HK) that is present in Candida albicans. It was found to be a target for antifungal activities on the hyperosmotic glycerol pathway.
Mohammed El-Mowafy, Ursula Bilitewski
doaj +1 more source
SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus
PLoS Pathogens, 2018 The success of Staphylococcus aureus, as both a human and animal pathogen, stems from its ability to rapidly adapt to a wide spectrum of environmental conditions. Two-component systems (TCSs) play a crucial role in this process. Here, we describe a novel
O. Poupel +4 more
semanticscholar +1 more source