Results 61 to 70 of about 82,686 (281)

Cytokinin receptor: Just another histidine kinase [PDF]

Current Biology, 2001
The cytokinin family of plant hormones is involved in diverse aspects of plant growth and development in vivo and in culture. Two groups have recently shown that a two-component histidine kinase functions as a cytokinin receptor specifically required for vascular development.
openaire   +2 more sources

Determinants of Homodimerization Specificity in Histidine Kinases [PDF]

Journal of Molecular Biology, 2011
Two-component signal transduction pathways consisting of a histidine kinase and a response regulator are used by prokaryotes to respond to diverse environmental and intracellular stimuli. Most species encode numerous paralogous histidine kinases that exhibit significant structural similarity.
Ashenberg, Orr, Rozen-Gagnon, Kathryn, Keating, Amy E., Laub, Michael T   +3 more
openaire   +4 more sources

An Engineered Solidified Peptide Hemocyte Sponge as Nanomotor Storage to Combat Bacterial Colitis

Advanced Science, EarlyView.
Peptides immobilized via nickel coordination can stabilize the framework structure. Following coating with red blood cell membranes, these constructs are capable of continuously sequestering endotoxins and mitigating colonic pathogenic damage by alleviating bacterial‐induced ferroptosis.
Yuxin Fang, Jianming Yan, Tongxin Yu, Zichuan An, Kaikai Lv, Chenyu Xue, Hongyang Yu, Na Dong, Anshan Shan   +8 more
wiley   +1 more source

Evolutionary Relationships among Virulence-Associated Histidine Kinases [PDF]

Infection and Immunity, 2001
ABSTRACT A strong relationship between virulence-associated sensor histidine kinases of fungi and those in Streptomyces coelicolor was observed, and phylogenetic analysis suggested that bacterium-to-eukaryote horizontal gene transfer had occurred between ancestors of these organisms.
F S, Brinkman, E L, Macfarlane, P, Warrener, R E, Hancock   +3 more
openaire   +2 more sources

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

His kinase or mine? Histidine kinases through evolution

Journal of Biosciences, 2000
Sensing environmental changes and responding to them is the key to any organism’s survival. The simplest example of a sensor-response system is seen in bacteria in the form of what is known as the two-component system. This system involves proteins in which the sensor or component I detects the stimulus via its input or sensor domain and is trans ...
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Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
ABSTRACT This special issue marking the University of Bath's 60th anniversary offers an opportunity to reflect on nearly a decade of research into the evolution of gene regulatory networks (GRNs) from members of the lab and elsewhere. Our goal is to understand how GRNs rewire and how new transcription factor (TF) functions evolve. Using an experimental
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Diversity of two-component systems: insights into the signal transduction mechanism by the Staphylococcus aureus two-component system GraSR [v2; ref status: indexed, http://f1000r.es/4qf]

F1000Research, 2014
The response to cationic antimicrobial peptides (CAMPs) in Staphylococcus aureus relies on a two-component system (TCS), GraSR, an auxiliary protein GraX and an ATP-binding cassette (ABC) transporter, VraF/G.
Uzma Muzamal, Daniel Gomez, Fenika Kapadia, Dasantila Golemi-Kotra   +3 more
doaj   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Signal transduction in photoreceptor histidine kinases [PDF]

Protein Science, 2019
AbstractTwo‐component systems (TCS) constitute the predominant means by which prokaryotes read out and adapt to their environment. Canonical TCSs comprise a sensor histidine kinase (SHK), usually a transmembrane receptor, and a response regulator (RR). In signal‐dependent manner, the SHK autophosphorylates and in turn transfers the phosphoryl group to ...
openaire   +2 more sources