The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae. [PDF]
Microbiol Spectr, 2022 Human norovirus (HuNoV) is the major agent for viral gastroenteritis, causing >700 million infections yearly. Fucose-containing carbohydrates named histo-blood group antigens (HBGAs) are known (co)receptors for HuNoV.
Cuvry A +6 more
europepmc +6 more sources
Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens. [PDF]
PLoS Pathog, 2019 Rotavirus is the leading agent causing acute gastroenteritis in young children, with the P[8] genotype accounting for more than 80% of infections in humans.
Gozalbo-Rovira R +8 more
europepmc +5 more sources
Lewis fucose is a key moiety for the recognition of histo-blood group antigens by GI.9 norovirus, as revealed by structural analysis. [PDF]
FEBS Open Bio, 2022 Noroviruses have been identified as major causative agents of acute nonbacterial gastroenteritis in humans. Histo‐blood group antigens (HBGAs) are thought to play a major role among the host cellular factors influencing norovirus infection.
Kimura-Someya T +7 more
europepmc +3 more sources
Evolution of the interactions between GII.4 noroviruses and histo-blood group antigens: Insights from experimental and computational studies. [PDF]
PLoS Pathog, 2021 Norovirus (NoV) is the major pathogen causing the outbreaks of the viral gastroenteritis across the world. Among the various genotypes of NoV, GII.4 is the most predominant over the past decades.
Liang Y +8 more
europepmc +4 more sources
Histo-Blood Group Antigens in Children with Symptomatic Rotavirus Infection. [PDF]
Viruses, 2019 Group A rotaviruses are a major cause of acute gastroenteritis in children. The diversity and unequal geographical prevalence of rotavirus genotypes have been linked to histo-blood group antigens (HBGAs) in different human populations.
Pérez-Ortín R +5 more
europepmc +3 more sources
Norovirus Binding to Ligands Beyond Histo-Blood Group Antigens. [PDF]
Front Microbiol, 2017 Histo-blood group antigens (HBGAs) are commonly accepted as the cellular receptors for human norovirus. However, some human noroviruses have been found not to bind any HBGA ligand, suggesting potential additional co-factors.
Almand EA, Moore MD, Jaykus LA.
europepmc +3 more sources
Histo-Blood Group Antigens in Oral Cancer and Potentially Malignant Disorders. [PDF]
Asian Pac J Cancer Prev, 2020 Background: Early detection of oral cancer is of critical importance because survival rates markedly improve when oral lesions are identified at an early stage.
Pokala A +5 more
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Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens. [PDF]
PLoS Pathog, 2020 Initial cell attachment of rotavirus (RV) to specific cell surface glycan receptors, which is the essential first step in RV infection, is mediated by the VP8* domain of the spike protein VP4.
Xu S +10 more
europepmc +3 more sources
Bovine Nebovirus Interacts with a Wide Spectrum of Histo-Blood Group Antigens. [PDF]
J Virol, 2018 Some viruses within the Caliciviridae family initiate their replication cycle by attachment to cell surface carbohydrate moieties, histo-blood group antigens (HBGAs), and/or terminal sialic acids (SAs).
Cho EH +11 more
europepmc +4 more sources
Structural Constraints on Human Norovirus Binding to Histo-Blood Group Antigens. [PDF]
mSphere, 2016 Human norovirus interacts with the polymorphic human histo-blood group antigens (HBGAs), and this interaction is thought to be important for infection. The genogroup II genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every other year, and
Singh BK, Leuthold MM, Hansman GS.
europepmc +3 more sources