The histo-blood group antigens of the host cell may determine the binding of different viruses such as SARS-CoV-2. [PDF]
Future Microbiol, 2021 Viruses have caused the death of millions of people worldwide. Specifically, human viruses are grouped into 21 families, including the family of coronaviruses (CoVs). In December 2019, in Wuhan, China, a new human CoV was identified, SARS-CoV-2.
Cuéllar-Cruz M.
europepmc +2 more sources
Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance Group A rotaviruses cause severe gastroenteritis in infants and young children worldwide, with P[II] genogroup rotaviruses (RVs) responsible for >90% of global cases. Existing RV vaccines are successful in many developed countries, but their
Xu S +10 more
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Free Chlorine and Peroxynitrite Alter the Capsid Structure of Human Norovirus GII.4 and Its Capacity to Bind Histo-Blood Group Antigens. [PDF]
Front Microbiol, 2021 Human noroviruses (HuNoVs) are one of the leading causes of acute gastroenteritis worldwide. HuNoVs are frequently detected in water and foodstuffs. Free chlorine and peroxynitrite (ONOO−) are two oxidants commonly encountered by HuNoVs in humans or in ...
Chassaing M +7 more
europepmc +2 more sources
Histo-Blood Group Antigens, Enteropathogen Carriage and Environmental Enteropathy in Stunted Zambian Children. [PDF]
J Pediatr Gastroenterol Nutr, 2022 Objectives: Stunting, the most common form of childhood undernutrition, is associated with environmental enteropathy (EE). Enteric infections are believed to play a role in the pathophysiology of EE and stunting though the exact mechanism remains ...
Chandwe K +8 more
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Histo-blood group antigens of glycosphingolipids predict susceptibility of human intestinal enteroids to norovirus infection. [PDF]
J Biol Chem, 2020 The molecular mechanisms behind infection and propagation of human restricted pathogens such as human norovirus (HuNoV) have defied interrogation because they were previously unculturable.
Rimkute I +12 more
europepmc +2 more sources
Histo-blood group antigens as divergent factors of groups A and C rotaviruses circulating in humans and different animal species. [PDF]
Emerg Microbes Infect, 2020 Histo-blood group antigens (HBGAs) have been found to be important host susceptibility factors or receptors for human rotavirus (RVs) with genotype-specific host ranges, impacting the disease patterns, epidemiology, and strategy development against RV ...
Zhao D +7 more
europepmc +2 more sources
A New Chemical Approach to Human ABO Histo-Blood Group Type 2 Antigens [PDF]
Molecules, 2013 A new chemical approach to synthesizing human ABO histo-blood type 2 antigenic determinants was developed. N-Phthaloyl-protected lactosaminyl thioglycoside derived from lactulose via the Heyns rearrangement was employed to obtain a type 2 core ...
Atsushi Hara +4 more
doaj +2 more sources
Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma. [PDF]
J Breast Cancer, 2020 Purpose Aberrant glycosylation of the histo-blood group antigens (including the angina bullosa haemorrhagica [ABH]) is often observed during malignant transformation in most types of carcinomas.
Zouine S +8 more
europepmc +2 more sources
Blood ties: ABO is a trans-species polymorphism in primates [PDF]
, 2012 The ABO histo-blood group, the critical determinant of transfusion incompatibility, was the first genetic polymorphism discovered in humans. Remarkably, ABO antigens are also polymorphic in many other primates, with the same two amino acid changes ...
A. Venkat +38 more
core +2 more sources
Snow Mountain Virus recovery by synthetic human histo-blood group antigens is heavily influenced by matrix effects. [PDF]
Sci Rep, 2020 Noroviruses are known to bind to histo-blood group antigens (HBGAs) and the specific binding patterns depend on the virus genotype. However, the development of point-of-care diagnostic assays based on this binding has been challenging due to low assay ...
Kirby AE +9 more
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