Results 41 to 50 of about 8,473,299 (309)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape. [PDF]

, 1994
An immediate-early protein of murine cytomegalovirus (MCMV), pp89, elicits an immunodominant and protective major histocompatibility complex (MHC) class I Ld-restricted CD8+ T-lymphocyte response.
Ruppert, Siegfried, Koszinowski, Ulrich H., Lucin, Pero, Jonjic, Stipan, Hengel, Hartmut   +4 more
core   +1 more source

Regulation of major histocompatibility complex class II gene expression in trophoblast cells

Reproductive Biology and Endocrinology, 2004
Trophoblast cells are unique because they are one of the few mammalian cell types that do not express major histocompatibility complex (MHC) class II antigens, either constitutively or after exposure to IFN-γ.
Choi Jason C, Murphy Shawn P, Holtz Renae   +2 more
doaj   +1 more source

Structural analysis of the adenovirus type 2 E3/19K protein using mutagenesis and a panel of conformation-sensitive monoclonal antibodies [PDF]

, 2008
The E3/19K protein of human adenovirus type 2 (Ad2) was the first viral protein shown to interfere with antigen presentation. This 25 kDa transmembrane glycoprotein binds to major histocompatibility complex (MHC) class I molecules in the endoplasmic ...
Menz, Beatrice, Schmid, Ralf, Burgert, Hans-Gerhard, Martina Sester, Hans-Gerhard Burgert, Sester, Martina, Koebernick, Katja, Beatrice Menz, Katja Koebernick, Ralf Schmid   +9 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation

iScience, 2019
Summary: Antigen presentation to T cells in major histocompatibility complex class II (MHC class II) requires the conversion of early endo/phagosomes into lysosomes by a process called maturation.
Maksim V. Baranov, Frans Bianchi, Anastasiya Schirmacher, Melissa A.C. van Aart, Sjors Maassen, Elke M. Muntjewerff, Ilse Dingjan, Martin ter Beest, Martijn Verdoes, Samantha G.L. Keyser, Carolyn R. Bertozzi, Ulf Diederichsen, Geert van den Bogaart   +12 more
doaj   +1 more source

CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system

Experimental and Molecular Medicine, 2023
The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid antigens. Moreover, the CD1-restricted T cells that recognize these self and foreign antigens participate in
Seohyun Kim, Sumin Cho, Ji Hyung Kim
doaj   +1 more source

Endogenous human cytomegalovirus gB is efficiently presented by MHC class II molecules to CD4+ CTL [PDF]

, 2005
Human cytomegalovirus (HCMV) infects endothelial, epithelial, and glial cells in vivo. These cells can express MHC class II proteins, but are unlikely to play important roles in priming host immunity.
Nelson, JA, Dunn, C, Johnson, DC, Hegde, NR, Lewinsohn, DM, Jarvis, MA   +5 more
core  

A peptide filtering relation quantifies MHC class I peptide optimization [PDF]

, 2011
Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to
Luca Cardelli, Goldstein, LD, Phillips, Andrew, Emmott, Stephen, Elliott, T, Mark Howarth, Werner, JM, Werner, Joern M., Leonard D. Goldstein, Andrew Phillips, Elliot, Tim, Dalchau, Neil, Goldstein, Leonard D., Cardelli, L, Cardelli, Luca, Tim Elliott, Dalchau, N, Emmott, S, Neil Dalchau, Howarth, M, Elliott, Tim, Leonard D Goldstein, Joern M. Werner, Phillips, A, Joern M Werner, Stephen Emmott, Howarth, Mark   +26 more
core   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source