Results 1 to 10 of about 13,333,450 (231)

Aspects of histocompatibility testing in xenotransplantation. [PDF]

Transpl Immunol, 2021
Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering
Ladowski JM, Houp J, Hauptfeld-Dolejsek V, Javed M, Hara H, Cooper DKC.   +5 more
europepmc   +7 more sources

Histocompatibility Testing for Organ Transplantation Purposes in Albania: A Single Center Experience [PDF]

Balkan Medical Journal, 2014
Background: Histocompatibility testing (HT) which includes donor-recipient human leukocyte antigen (HLA) matching, cross-match testing (XMT) and anti-HLA antibody searching are crucial examinations in solid organ transplantation aiming to avoid the ...
Erkena Shyti, Genc Sulcebe, Alma Idrizi
doaj   +3 more sources

HISTOCOMPATIBILITY TESTING IN THE RABBIT

Transplantation, 1967
A panel of isoantisera, prepared by injecting rabbit spleen cells and adjuvant was used to classify the leucocyte antigens of 52 rabbits. Blood leucocytes from each animal were incubated‘ with each antiserum and the damage was assessed by the eosin dye ...
L. M. Black
semanticscholar   +5 more sources

External proficiency testing for histocompatibility and immunogenetics in today and future [PDF]

Frontiers in Genetics
The Histocompatibility and Immunogenetics laboratories provide disease association and pharmacogenetic analyses as well as the tests required for transplantation immunology and transfusion medicine.
Fatma Savran Oguz
doaj   +4 more sources

Pretransplant histocompatibility testing algorithm: Laboratory and clinical approach in the Indian context

Indian Journal of Transplantation, 2021
Remarkable advances in histocompatibility testing have immensely improved the safety of transplantation and have decreased the incidence of rejections.
Feroz Aziz, Aseem K Tiwari, Himanshu V Patel, Rajni Chauhan   +3 more
doaj   +2 more sources

Major Histocompatibility Complex Binding, Eluted Ligands, and Immunogenicity: Benchmark Testing and Predictions

Frontiers in Immunology, 2020
Antidrug antibody (ADA) responses impact drug safety, potency, and efficacy. It is generally assumed that ADA responses are associated with human leukocyte antigen (HLA) class II-restricted CD4+ T-cell reactivity.
Sinu Paul, Alba Grifoni, Bjoern Peters, Bjoern Peters, Alessandro Sette, Alessandro Sette   +5 more
doaj   +2 more sources

Histocompatibility Testing: A Fundamental Aspect of Renal Transplant Workup [PDF]

Transplantology
Histocompatibility testing is pivotal in any renal transplantation workup, aimed at enhancing prospective donor recipient compatibility and improving transplant outcomes.
Vikash Chandra Mishra, Dinesh Chandra, Vimarsh Raina   +2 more
doaj   +2 more sources

AN AUTOMATED, RAPID, AND QUANTITATIVE MICROASSAY FOR HISTOCOMPATIBILITY TESTING

Transplantation, 1973
The lymphocytotoxicity microassay of histocompatibility testing was quantitated by the use of a new instrument, the Cytograf 6301. Reconstitution experiments and comparison with microscopic observations by technicians confirmed the sensitivity, accuracy,
Merlin R. Wilson, J. F. Dardano, Henry Rothschild   +2 more
openalex   +2 more sources

A special report: histocompatibility testing guidelines for hematopoietic stem cell transplantation using volunteer donors

Tissue Antigens, 1999
The World Marrow Donor Association has formulated guidelines for establishing the extent and quality of histocompatibility testing for unrelated donor registries, umbilical cord blood banks, and transplant centers involved in international exchange of ...
Carolyn Katovich Hurley, Judith A. Wade, Machteld Oudshoorn, Derek Middleton, Debra Kukuruga, Cristina Navarrete, Frank Christiansen, Janet Hegland, Ee-Chee Ren, Irene Andersen, Susan Cleaver, Chaim Brautbar, C Raffoux   +12 more
openalex   +2 more sources

Tools for histocompatibility testing and significance of panel reactive antibodies - A narrative review

Indian Journal of Transplantation, 2021
Immune response directed towards the allograft is a major barrier to the longterm graft survival in kidney transplantation. The importance of various tools for histocompatibility testing including the significance of panel reactive antibodies in ...
Praveen Kumar Etta
doaj   +2 more sources