Aspects of histocompatibility testing in xenotransplantation. [PDF]
Transpl Immunol, 2021 Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a solution to the organ shortage. The biggest barrier to clinical implementation is the antigenicity of pig cells. Humans possess preformed antibody to pig cells that initiate antibody-mediated rejection of pig organs in primates. Advances in genetic engineering
Ladowski JM +5 more
europepmc +4 more sources
Histocompatibility Testing: A Fundamental Aspect of Renal Transplant Workup
TransplantologyHistocompatibility testing is pivotal in any renal transplantation workup, aimed at enhancing prospective donor recipient compatibility and improving transplant outcomes.
Vikash Chandra Mishra +2 more
doaj +3 more sources
Seventy-five years of service: an overview of the College of American Pathologists’ proficiency testing program in histocompatibility and identity testing [PDF]
Frontiers in Genetics, 2023 The Histocompatibility and Identity Testing Committee offers an overview of the College of American Pathologists’ (CAP) Proficiency Testing (PT) program, commemorating its significant 75th anniversary in 2024. The CAP PT program has undergone significant
H. Cliff Sullivan +13 more
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Histocompatibility Testing for Organ Transplantation Purposes in Albania: A Single Center Experience [PDF]
Balkan Medical Journal, 2014 Background: Histocompatibility testing (HT) which includes donor-recipient human leukocyte antigen (HLA) matching, cross-match testing (XMT) and anti-HLA antibody searching are crucial examinations in solid organ transplantation aiming to avoid the ...
Erkena Shyti, Genc Sulcebe, Alma Idrizi
doaj +2 more sources
Indian Journal of Transplantation, 2021 Remarkable advances in histocompatibility testing have immensely improved the safety of transplantation and have decreased the incidence of rejections.
Feroz Aziz +3 more
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Frontiers in Immunology, 2020 Antidrug antibody (ADA) responses impact drug safety, potency, and efficacy. It is generally assumed that ADA responses are associated with human leukocyte antigen (HLA) class II-restricted CD4+ T-cell reactivity.
Sinu Paul +5 more
doaj +2 more sources
A modular verification and validation framework for hybrid-capture next-generation sequencing HLA typing in clinical histocompatibility laboratories [PDF]
Frontiers in GeneticsHybrid-capture next-generation sequencing HLA workflows are increasingly used in clinical histocompatibility laboratories for high-resolution HLA typing.
Alice Scarpa +4 more
doaj +2 more sources
Deceased organ donation: laboratory testing and histocompatibility assessment in Korea
Clinical Transplantation and ResearchHistocompatibility testing is essential for ensuring both safety and fairness in deceased donor organ transplantation. In Korea, such testing is strictly regulated under the Organ Transplant Act and centralized within organ procurement organization ...
Borae G. Park, Samuel Lee
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Status quo of histocompatibility testing and prospects for virtual crossmatching within the Korean kidney allocation system: survey of laboratory directors [PDF]
Clinical Transplantation and ResearchBackground : The Korean kidney allocation system (KAS) currently imposes disparities for highly sensitized candidates because it does not account for human leukocyte antigen (HLA) antibody-defined unacceptable antigens.
John Jeongseok Yang +6 more
doaj +2 more sources
Current status and perspectives of the quality system in histocompatibility laboratories in Poland [PDF]
Frontiers in GeneticsAllogeneic transplantation is a multi-step process involving many clinicians and laboratory personnel working together to achieve a common goal—to maximize the recipients’ chance of survival and to improve their quality of life.
Izabela Uhrynowska-Tyszkiewicz +6 more
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