Results 91 to 100 of about 570,523 (273)
Frontiers in Pharmacology, 2017 Introduction: Epigenetic regulation of fibrogenesis through post-translational histone modifications (marks) may be a key determinant of progression in renal disease. In this study, we examined the distribution and acquisition of histone 3 Lysine 9 (H3K9)
Timothy D. Hewitson +8 more
doaj +1 more source
The histone octamer influences the wrapping direction of DNA on it: Brownian dynamics simulation of the nucleosome chirality [PDF]
Journal of Theoretical Biology 235 (2005) 365-372, 2005 In eukaryote nucleosome, DNA wraps around a histone octamer in a left-handed way. We study the process of chirality formation of nucleosome with Brownian dynamics simulation. We model the histone octamer with a quantitatively adjustable chirality: left-handed, right-handed or non-chiral, and simulate the dynamical wrapping process of a DNA molecule on ...
arxiv
Controlled DNA compaction within chromatin: the tail-bridging effect [PDF]
, 2005 We study the mechanism underlying the attraction between nucleosomes, the fundamental packaging units of DNA inside the chromatin complex. We introduce a simple model of the nucleosome, the eight-tail colloid, consisting of a charged sphere with eight oppositely charged, flexible, grafted chains that represent the terminal histone tails. We demonstrate
arxiv +1 more source
DeepChrome: Deep-learning for predicting gene expression from histone modifications [PDF]
arXiv, 2016 Motivation: Histone modifications are among the most important factors that control gene regulation. Computational methods that predict gene expression from histone modification signals are highly desirable for understanding their combinatorial effects in gene regulation. This knowledge can help in developing 'epigenetic drugs' for diseases like cancer.
arxiv
Histone Modifications and Cancer.
Cold Spring Harbor Perspectives in Biology, 2016 Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin.
J. Audia, R. Campbell
semanticscholar +1 more source
A quantum spin approach to histone dynamics [PDF]
arXiv, 2009 Post-translational modifications of histone proteins are an important factor in epigenetic control that serve to regulate transcription, depending on the particular modification states of the histone proteins. We study the stochastic dynamics of histone protein states, taking into account a feedback mechanism where modified nucleosomes recruit enzymes ...
arxiv
Epigenetic Dynamics of Cell Reprogramming [PDF]
arXiv, 2014 Reprogramming is a process of transforming differentiated cells into pluripotent stem cells by inducing specific modifying factors in the cells. Reprogramming is a non-equilibrium process involving a collaboration at levels separated by orders of magnitude in time scale, namely transcription factor binding/unbinding, protein synthesis/degradation, and ...
arxiv
Epigenetics, 2017 Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin
Eleonore Maury, Rintaro Hashizume
doaj +1 more source
Modeling the dynamics of bivalent histone modifications [PDF]
arXiv, 2013 Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have "bivalent domains" in which the nucleosomes contain both active (H3K4me3) and repressive (H3K27me3) marks. It is generally agreed that
arxiv
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
Science, 2019 Oxygen sensing revisited The cellular response to hypoxia (oxygen deficiency) is a contributing factor in many human diseases. Previous studies examining the way in which hypoxia alters gene expression have focused on oxygen-sensing enzymes that regulate
A. Chakraborty +18 more
semanticscholar +1 more source