Results 91 to 100 of about 724,595 (331)
Expression profile of CREB knockdown in myeloid leukemia cells. [PDF]
, 2008 BackgroundThe cAMP Response Element Binding Protein, CREB, is a transcription factor that regulates cell proliferation, differentiation, and survival in several model systems, including neuronal and hematopoietic cells.
Cheng, Jerry C +6 more
core +2 more sources
Frontiers in Endocrinology, 2018 Gonadotropin-releasing hormone (GnRH) stimulates the expression of multiple genes in the pituitary gonadotropes, most notably to induce synthesis of the gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH), but also to ensure ...
Philippa Melamed +6 more
doaj +1 more source
Mapping Influenza-Induced Posttranslational Modifications on Histones from CD8+ T Cells
Viruses, 2020 T cell function is determined by transcriptional networks that are regulated by epigenetic programming via posttranslational modifications (PTMs) to histone proteins and DNA.
Svetlana Rezinciuc +5 more
doaj +1 more source
On the origin of the histone fold [PDF]
BMC Structural Biology, 2007 AbstractBackgroundHistones organize the genomic DNA of eukaryotes into chromatin. The four core histone subunits consist of two consecutive helix-strand-helix motifs and are interleaved into heterodimers with a unique fold. We have searched for the evolutionary origin of this fold using sequence and structure comparisons, based on the hypothesis that ...
Alva, Vikram +3 more
openaire +5 more sources
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
From supramolecular chemistry to the nucleosome: studies in biomolecular recognition
Beilstein Journal of Organic Chemistry, 2016 This review highlights the author’s indirect path to research at the interface of supramolecular chemistry and chemical biology.
Marcey L. Waters
doaj +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Histone Mutants Separate R Loop Formation from Genome Instability Induction [PDF]
, 2017 R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R loops but do not cause instability.
Aguilera López, Andrés +5 more
core +1 more source
Molecules, 2018 With the increasing interest in scarce proteins, reducing the sample volume for circular dichroism (CD) spectroscopy has become desirable. Demagnification of the incident beam size is required to reduce the sample volume for CD spectroscopy detecting ...
Yudai Izumi, Koichi Matsuo
doaj +1 more source
Lysine methyltransferase SETD6 modifies histones on a glycine-lysine motif
Epigenetics, 2020 Although central to regulating the access to genetic information, most lysine methyltransferases remain poorly characterised relative to other family of enzymes. Herein, I report new substrates for the lysine methyltransferase SETD6.
Olivier Binda
doaj +1 more source