Results 41 to 50 of about 617,156 (199)

Histone variants at a glance

Journal of Cell Science, 2021
Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA entering and exiting the particle may be bound by the linker histone H1.
P. Talbert, S. Henikoff
semanticscholar   +1 more source

Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish

Antibiotics, 2021
Correlation studies about NOD1 and histones have not been reported. In the present study, we report the functional correlation between NOD1 and the histone H2A variant in response to Streptococcus agalactiae infection.
Xiaoman Wu, Fan Xiong, Hong Fang, Jie Zhang, Mingxian Chang   +4 more
doaj   +1 more source

Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer

Cells, 2019
Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers.
Lucile M-P Jeusset, Kirk J McManus
doaj   +1 more source

Writing, erasing and reading histone lysine methylations

Experimental &Molecular Medicine, 2017
Histone modifications are key epigenetic regulatory features that have important roles in many cellular events. Lysine methylations mark various sites on the tail and globular domains of histones and their levels are precisely balanced by the action of ...
K. Hyun, Jongcheol Jeon, Kihyun Park, Jaehoon Kim   +3 more
semanticscholar   +1 more source

Increased histone citrullination in juvenile idiopathic arthritis

Frontiers in Medicine, 2022
ObjectivePosttranslational modifications (PTMs) of proteins are crucial for regulating various biological processes. However, protein alteration via PTMs, and consequently, the creation of new epitopes, can induce abnormal autoimmune responses in ...
Zuzana Parackova, Irena Zentsova, Hana Malcova, Dita Cebecauerova, Anna Sediva, Rudolf Horvath   +5 more
doaj   +1 more source

Accelerated Deficits of Spatial Learning and Memory Resulting From Prenatal Inflammatory Insult Are Correlated With Abnormal Phosphorylation and Methylation of Histone 3 in CD-1 Mice

Frontiers in Aging Neuroscience, 2019
Gestational infection causes various neurological deficits in offspring, such as age-related spatial learning and memory (SLM) decline. How inflammation causes age-related SLM dysfunction remains unknown.
Zi-Xing Wu, Zi-Xing Wu, Lei Cao, Xue-Wei Li, Wei Jiang, Xue-Yan Li, Jing Xu, Fang Wang, Gui-Hai Chen   +8 more
doaj   +1 more source

Further biochemical characterization of Mycobacterium leprae laminin-binding proteins

Brazilian Journal of Medical and Biological Research, 2001
It has been demonstrated that the alpha2 chain of laminin-2 present on the surface of Schwann cells is involved in the process of attachment of Mycobacterium leprae to these cells. Searching for M. leprae laminin-binding molecules, in a previous study we
M.A.M. Marques, S. Mahapatra, E.N. Sarno, S. Santos, J.S. Spencer, P.J. Brennan, M.C.V. Pessolani   +6 more
doaj   +1 more source

Histone Deacetylase Inhibitors as Anticancer Drugs

International Journal of Molecular Sciences, 2017
Carcinogenesis cannot be explained only by genetic alterations, but also involves epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic regulation of gene expression and is controlled by the balance between histone ...
T. Eckschlager, Johana Plch, M. Stiborová, J. Hraběta   +3 more
semanticscholar   +1 more source

Characterization of a drought inducible trithorax-like H3K4 methyltransferase from barley

Biologia Plantarum, 2012
Histone H3 lysine 4 methylations catalyzed by histone lysine methyltransferases (HKMTs), like the Arabidopsis thaliana ATX1 and ATX2, are important epigenetic modifications related to chromatin decondensation and gene activation.
D. Papaefthimiou, A. S. Tsaftaris
doaj   +1 more source

How Histone Sensing Drives Alzheimer’s Disease

Frontiers in Bioscience-Landmark
The human DNA double helix is wrapped around proteins known as histones, which play a critical role in regulating gene expression. The goal of this opinion piece is to provide an overview of how histone sensing drives Alzheimer’s disease (AD).
Jia-Ping Wu
doaj   +1 more source