Results 61 to 70 of about 724,595 (331)

Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant [PDF]

, 2013
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease.
A. D. McAinsh, A. Desai, A. F. Straight, A. Losada, A. Musacchio, B. A. Sullivan, B. E. Black, B. G. Mellone, B. R. Brinkley, BA Sullivan, C. E. Sunkel, C. E. Walczak, CJ Lawrence, D. Foltz, D. M. Glover, D. W. Cleveland, D. W. Gerlich, DK Palmer, DR Foltz, E. D. Salmon, ES Alnemri, G. J. Gorbsky, G. J. P. L. Kops, G. Karpen, G. P. Copenhaver, H. F. Willard, H. Maiato, H. Masumoto, I. M. Cheeseman, J Ohzeki, J. G. DeLuca, J. R. Swedlow, K. Bloom, K. C. Scott, K. F. Sullivan, K. H. A. Choo, K. Luger, K. Oegema, K. Yoda, KF Sullivan, L. E. T. Jansen, L. Wordeman, M. A. Lampson, M. Fitzgerald-Hayes, M. Yanagida, MD Blower, P. E. Warburton, P. Heun, P. Meraldi, P. S. Maddox, P. T. Stukenberg, PB Talbert, R. C. Allshire, R. Gassmann, R. J. O’Neill, R. L. Margolis, S Ando, S Henikoff, S Stoler, S. C. Harrison, S. Diekmann, S. Erhardt, S. M. Lens, S. Westermann, SA Ribeiro, T Hori, T Nishino, T. Fukagawa, T. Hirota, T. J. Yen, W. Brown, W. C. Earnshaw, WC Earnshaw   +72 more
core   +8 more sources

Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11

FEBS Open Bio, 2020
Ferroptosis is a type of adaptive cell death driven by cellular metabolism and iron‐dependent lipid peroxidation. Though multiple genes (including SLC7A11 and GPX4) have been demonstrated to play key roles in ferroptosis, little is known about the ...
Yishu Wang, Yao Zhao, Haihua Wang, Chengliang Zhang, Meiqi Wang, Yong Yang, Xin Xu, Zhenbo Hu   +7 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Pharmacological Inhibition of LSD1 for Cancer Treatment

Molecules, 2018
Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell ...
Guan-Jun Yang, Pui-Man Lei, Suk-Yu Wong, Dik-Lung Ma, Chung-Hang Leung   +4 more
doaj   +1 more source

Early Life Stress- and Drug-Induced Histone Modifications Within the Ventral Tegmental Area

Frontiers in Cell and Developmental Biology, 2020
Psychiatric illnesses are a major public health concern due to their prevalence and heterogeneity of symptom presentation resulting from a lack of efficacious treatments.
Ryan D. Shepard, Fereshteh S. Nugent
doaj   +1 more source

Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish

Antibiotics, 2021
Correlation studies about NOD1 and histones have not been reported. In the present study, we report the functional correlation between NOD1 and the histone H2A variant in response to Streptococcus agalactiae infection.
Xiaoman Wu, Fan Xiong, Hong Fang, Jie Zhang, Mingxian Chang   +4 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Nickel binding sites in histone proteins [PDF]

, 2012
Nickel compounds are well known as human carcinogens, though the molecular events that are responsible for this are not well understood. It has been proposed that a crucial element in the mechanism of carcinogenesis is the binding of Ni(II) ions within
Medici, Serenella, Peana, Massimiliano Francesco, Solinas, Costantino, Zoroddu, Maria Antonietta   +3 more
core  

New Insights in Transcriptional Regulation of the Ethylene Response in Arabidopsis

Frontiers in Plant Science, 2019
As any living organisms, plants must respond to a wide variety of environmental stimuli. Plant hormones regulate almost all aspects of plant growth and development.
Likai Wang, Likai Wang, Hong Qiao, Hong Qiao   +3 more
doaj   +1 more source

The First Analysis of Synaptonemal Complexes in Jawless Vertebrates: Chromosome Synapsis and Transcription Reactivation at Meiotic Prophase I in the Lamprey Lampetra fluviatilis (Petromyzontiformes, Cyclostomata)

Life, 2023
Transcription is known to be substage-specific in meiotic prophase I. If transcription is reactivated in the mid pachytene stage in mammals when synapsis is completed, then this process is observed in the zygotene stage in insects.
Sergey Matveevsky, Nikolay Tropin, Aleksandr Kucheryavyy, Oxana Kolomiets   +3 more
doaj   +1 more source