Results 61 to 70 of about 772,216 (334)
Chaperones and Beyond as Key Players in Pluripotency Maintenance
Frontiers in Cell and Developmental Biology, 2019 Pluripotency is orchestrated by distinct players and chaperones and their partners have emerged as pivotal molecules in proteostasis control to maintain stemness.
Camila Felix de Lima Fernandes +4 more
doaj +1 more source
First report of root and crown rot caused by Dactylonectria novozelandica on strawberry in Uruguay
Agrociencia Uruguay, 2022 Since 2015, a high mortality rate of strawberry plants has been observed in the north of Uruguay related to crown and root diseases caused by a pathogens complex. In 2016, associated with the death of plants, Cylindrocarpon spp.
Micaela Vigliecca +4 more
doaj +1 more source
Nickel binding sites in histone proteins [PDF]
, 2012 Nickel compounds are well known as human carcinogens, though the molecular events that are responsible for this are not well understood. It has been proposed that a crucial element in the mechanism of carcinogenesis is the binding of Ni(II) ions within
Medici, Serenella +3 more
core
Regulation of transcription by the Arabidopsis UVR8 photoreceptor involves a specific histone modification [PDF]
, 2016 The photoreceptor UV RESISTANCE LOCUS 8 (UVR8) specifically mediates photomorphogenic responses to UV-B wavelengths. UVR8 acts by regulating transcription of a set of genes, but the underlying mechanisms are unknown. Previous research indicated that UVR8
Herzyk, Pawel +2 more
core +1 more source
Non-mammalian model organisms in epigenetic research : an overview [PDF]
, 2020 Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik +3 more
core +2 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Antibiotics, 2021 Correlation studies about NOD1 and histones have not been reported. In the present study, we report the functional correlation between NOD1 and the histone H2A variant in response to Streptococcus agalactiae infection.
Xiaoman Wu +4 more
doaj +1 more source
Epigenomes in Cardiovascular Disease. [PDF]
, 2018 If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA +4 more
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer
Cells, 2019 Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes such as gene transcription and DNA damage repair. Importantly, the cellular machinery regulating histone ubiquitination is frequently altered in cancers.
Lucile M-P Jeusset, Kirk J McManus
doaj +1 more source