Results 251 to 260 of about 189,363 (327)

Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator

, 1999
Raymond C. Trievel, Jeannie R. Rojas, David E. Sterner, Ravichandran N. Venkataramani, Lian Wang, Zhou Jian-xin, C. David Allis, Shelley L. Berger, Ronen Marmorstein   +8 more
openalex   +2 more sources

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source

From allergens to epigenetics: how histone acetylation shapes immune gene expression in allergic diseases. [PDF]

Epigenomics
Cai X, Afthab M, Hambo S, Salem M, Bhitale RR, Harb H.   +5 more
europepmc   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

AIPred: comprehensive prediction and analysis of non-histone acetylation via protein language model and interpretable machine learning. [PDF]

BMC Biol
Geng Y, Luo H, Gao F.
europepmc   +1 more source

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, EarlyView.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source

Unraveling the role of histone acetylation in sepsis biomarker discovery. [PDF]

Front Mol Biosci
Cheng F, Deng J, Du Z, Li L, Qiu Z, Zhu M, Zhao H, Wang Z.   +7 more
europepmc   +1 more source

Histone acetylation by SAGA Complex but not by NuA4 Complex is Required for filamentation programme in Candida albicans [PDF]

Priyanka Nagar, Basharat Bashir Teli, Divya Dinesh, Krishnamurthy Natarajan   +3 more
openalex   +1 more source

[Histone acetylation].

Postepy biochemii, 1986
openaire   +1 more source

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source