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TCA cycle rewiring underpins implantation and histone acetylation programming
Kafkia E +11 more
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SlPLT6 controls ripening initiation and quality traits through modulation of histone acetylation and methylation in tomato. [PDF]
He X +15 more
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Sex-Related Differences in Histone Acetylation and Tumor Development in a 4-Nitroquinoline 1-Oxide and Ethanol-Induced Oral Squamous Cell Carcinoma Mouse Model. [PDF]
Nazário WR +9 more
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Life Sciences, 1981
Abstract Myocardial histone acetylation was investigated in an isolated perfused heart preparation. Radioactive acetate rapidly accumulated in the intracellular compartment which preceded the covalent modification of histones. The acetylation of nucleohistones was rapid and reached a maximum during the first 20 min of perfusion.
P B, Taylor, E A, Cook
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Abstract Myocardial histone acetylation was investigated in an isolated perfused heart preparation. Radioactive acetate rapidly accumulated in the intracellular compartment which preceded the covalent modification of histones. The acetylation of nucleohistones was rapid and reached a maximum during the first 20 min of perfusion.
P B, Taylor, E A, Cook
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Histone Acetylation and Histone Deacetylation
Molecular Biotechnology, 2002Regulation of inflammatory gene transcription is controlled, at least in part, by the degree of local unwinding of nucleosomal DNA. This unwinding is regulated by histone acetylation--increased acetylation results in a more loosely wound structure allowing access of basal transcription factors and RNA polymerase II.
Kazuhiro, Ito, Ian M, Adcock
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Histone acetylation and disease
Cellular and Molecular Life Sciences, 2001Differential acetylation of histones and transcription factors plays an important regulatory role in developmental processes, proliferation and differentiation. Aberrant acetylation or deacetylation leads to such diverse disorders as leukemia, epithelial cancers, fragile X syndrome and Rubinstein-Taybi syndrome.
S, Timmermann +3 more
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Histone acetylation and cancer
Current Opinion in Genetics & Development, 1999In the past year, several papers have been published which implicate a link between alterations in chromatin structure and the development of cancer. Both histone hyperacetylation and hypoacetylation appear to be important in the neoplastic process, depending on the target gene involved. In the case of colon cancer, induction of the p21 gene by histone
S Y, Archer, R A, Hodin
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Histone Acetylation in Neurodevelopment
Current Pharmaceutical Design, 2013Post-translational modification of histones is a primary mechanism through which epigenetic regulation of DNA transcription does occur. Among these modifications, regulation of histone acetylation state is an important tool to influence gene expression.
Antonio, Contestabile, Silvia, Sintoni
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Patterns of histone acetylation
European Journal of Biochemistry, 1990The N‐terminal domains of all four core histones are subject to reversible acetylation at certain lysine residues. This modification has been functionally linked to transcription, histone deposition at replication and to histone removal during spermatogenesis.
A W, Thorne +4 more
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Genomewide histone acetylation microarrays
Methods, 2003Histone acetylation and methylation are important regulators of gene activity. Chromatin immunoprecipitation (ChIP or ChrIP) has made it possible to examine not only the state of histone acetylation at a gene but also that of histone methylation and may soon be extended to other histone modifications such as phosphorylation and ubiquitination.
Daniel, Robyr, Michael, Grunstein
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