Results 301 to 310 of about 404,910 (338)
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Histone Acetylation and Chromatin Remodeling
Experimental Cell Research, 2001Chromatin represents a repressive barrier to the process of transcription. This molecular obstacle is a highly dynamic structure, able to compact the DNA of the entire genome into the confines of a nucleus, and yet it allows access to the genetic information held within.
P D, Gregory, K, Wagner, W, Hörz
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Temporal changes in histone acetylation
Mechanisms of Ageing and Development, 1978The incorporation of tritiated acetate was studied in developing and aging rats. Thymus, liver and serum were collected 30 minutes after injection of acetate. The trichloroacetic acid precipitable histone fraction was then extracted from liver and thymus and its radioactivity determined. Serum and cytoplasmic fractions were also counted. Serum activity
M, Petricevic, C W, Denko, L, Messineo
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DNA methylation models histone acetylation
Nature, 1998One of the main determinants of chromatin structure is histone acetylation1. Local chromosomal acetylation can be regulated dynamically, both through the involvement of transactivating factors with intrinsic histone acetylase activity, and through the recruitment of deacetylase complexes that repress gene expression2.
Eden, S. +4 more
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2015
Histone acetylation is the most widespread and pleiotropic of all histone modifications. Initially it was believed to alter gene expression simply by altering the physical compaction of chromatin but it is now recognised that the effects are far more subtle and varied than this.
Daniel Vitt +2 more
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Histone acetylation is the most widespread and pleiotropic of all histone modifications. Initially it was believed to alter gene expression simply by altering the physical compaction of chromatin but it is now recognised that the effects are far more subtle and varied than this.
Daniel Vitt +2 more
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Histone acetylation: chromatin in action
Trends in Biochemical Sciences, 1997Histone acetylation acts as a landmark and determinant for chromatin function. Active roles in the transcription and assembly of chromatin have been discovered for histone acetyltransferases and deacetylases. This review highlights these roles and discusses their significance for the maintenance of cell differentiation.
P A, Wade, D, Pruss, A P, Wolffe
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Acetylation of histones in nucleosomes
Molecular and Cellular Biochemistry, 1982A short review is given on the biochemistry of histone acetylation. Sites of acetylation in nucleosomal histones and enzymes involved in acetylation and deacetylation are discussed. Studies relating to the influence of these modifications on the structure of nucleosomes and chromatin are especially emphasized in this article.
D, Doenecke, D, Gallwitz
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Histone acetylation: facts and questions
Chromosoma, 1994The DNA of eukaryotic cells is organized in a complex with proteins, either as interphase chromatin or mitotic chromosomes. Nucleosomes, the structural subunits of chromatin, have long been considered as static structures, incompatible with processes occurring in chromatin.
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In Vitro Histone Acetylation Assay
Current Protocols in Pharmacology, 2017AbstractAcetylation is a core cellular process involved in maintaining genomic integrity, gene regulation, and metabolism. Histone acetyltransferases (HATs) are an enzyme family that regulates these processes by catalyzing the transfer of an acetyl moiety onto target proteins.
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Histone acetylation regulated by histone deacetylases during spermatogenesis
AndrologyAbstractBackgroundPhysical, chemical, and biological factors in the environment constantly influence in vivo and in vitro biological processes, including diverse histone modifications involved in cancer and metabolism. However, the intricate mechanisms of acetylation regulation remain poorly elucidated. In mammalian spermatogenesis, acetylation plays a
Xiangying Ou +4 more
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Histone Acetylation and Deacetylation
2012Gene expression in eukaryotic organisms can be influenced by a host of internal and external stimuli. The magnitude and duration of the response can often determine the effect of a diverse array of biological functions, many of which can be driven by gene expression.
Daniel M. Fass +5 more
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