Results 291 to 300 of about 404,910 (338)

Histone acetylation and disease

Cellular and Molecular Life Sciences, 2001
Differential acetylation of histones and transcription factors plays an important regulatory role in developmental processes, proliferation and differentiation. Aberrant acetylation or deacetylation leads to such diverse disorders as leukemia, epithelial cancers, fragile X syndrome and Rubinstein-Taybi syndrome.
S, Timmermann, H, Lehrmann, A, Polesskaya, A, Harel-Bellan   +3 more
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Histone acetylation and cancer

Current Opinion in Genetics & Development, 1999
In the past year, several papers have been published which implicate a link between alterations in chromatin structure and the development of cancer. Both histone hyperacetylation and hypoacetylation appear to be important in the neoplastic process, depending on the target gene involved. In the case of colon cancer, induction of the p21 gene by histone
S Y, Archer, R A, Hodin
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Histone Acetylation in Neurodevelopment

Current Pharmaceutical Design, 2013
Post-translational modification of histones is a primary mechanism through which epigenetic regulation of DNA transcription does occur. Among these modifications, regulation of histone acetylation state is an important tool to influence gene expression.
Antonio, Contestabile, Silvia, Sintoni
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Patterns of histone acetylation

European Journal of Biochemistry, 1990
The N‐terminal domains of all four core histones are subject to reversible acetylation at certain lysine residues. This modification has been functionally linked to transcription, histone deposition at replication and to histone removal during spermatogenesis.
A W, Thorne, D, Kmiciek, K, Mitchelson, P, Sautiere, C, Crane-Robinson   +4 more
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Genomewide histone acetylation microarrays

Methods, 2003
Histone acetylation and methylation are important regulators of gene activity. Chromatin immunoprecipitation (ChIP or ChrIP) has made it possible to examine not only the state of histone acetylation at a gene but also that of histone methylation and may soon be extended to other histone modifications such as phosphorylation and ubiquitination.
Daniel, Robyr, Michael, Grunstein
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Nonenzymatic acetylation of histones with acetyl-CoA

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1970
Abstract 1. When purified calf thymus histones were incubated with [1-14C]acetyl-CoA and treated to remove the acid-soluble fraction with trichloroacetic acid, a large amount of radioactivity still remained in the 15 % trichloroacetic acid-insoluble precipitate. 2.
W K, Paik, D, Pearson, H W, Lee, S, Kim
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Nonenzymic acetylation of histones with acetyl phosphate and acetyl adenylate

Biochemistry, 1975
Nonenzymatic acetylation of calf-thymus lysine- and arginine-rich histones was demonstrated to occur when these proteins were incubated with [14C]acetyl phosphate and [14C]acetyl adenylate. The levels of acetylation depend on both pH and on reagent concentration.
RAMPONI, GIAMPIETRO, MANAO, GIAMPAOLO, CAMICI, GUIDO   +2 more
openaire   +3 more sources

Histone Acetylation and Gastrointestinal Carcinogenesis

Annals of the New York Academy of Sciences, 2003
Abstract: The importance of altered histone acetylation in gastrointestinal carcinogenesis, especially in relation to invasion and metastasis, is described. Histone acetylation and chromatin remodeling linked with CpG island methylation play a major role in epigenetic regulation of gene expression.
Wataru, Yasui, Naohide, Oue, Shigehiro, Ono, Yoshitsugu, Mitani, Reiko, Ito, Hirofumi, Nakayama   +5 more
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Histone acetylation and X inactivation

Developmental Genetics, 1998
In mammals, the levels of X-linked gene products in males and females are equalised by the silencing, early in development, of most of the genes on one of the two female X chromosomes. Once established, the silent state is stable from one cell generation to the next. In eutherian mammals, the inactive X chromosome (Xi) differs from its active homologue
A M, Keohane, J S, Lavender, L P, O'Neill, B M, Turner   +3 more
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Histone Acetylation in Insect Chromosomes

Science, 1968
Acetylation of histones takes place along the salivary gland chromosomes of Chironomus thummi when RNA synthesis is active. It can be observed but not measured quantitatively by autoradiography of chromosome squashes.
V G, Allfrey, B G, Pogo, V C, Littau, E L, Gershey, A E, Mirsky   +4 more
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