Results 301 to 310 of about 189,363 (327)

Nonenzymatic acetylation of histones with acetyl-CoA

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1970
Abstract 1. When purified calf thymus histones were incubated with [1-14C]acetyl-CoA and treated to remove the acid-soluble fraction with trichloroacetic acid, a large amount of radioactivity still remained in the 15 % trichloroacetic acid-insoluble precipitate. 2.
W K, Paik, D, Pearson, H W, Lee, S, Kim
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Nonenzymic acetylation of histones with acetyl phosphate and acetyl adenylate

Biochemistry, 1975
Nonenzymatic acetylation of calf-thymus lysine- and arginine-rich histones was demonstrated to occur when these proteins were incubated with [14C]acetyl phosphate and [14C]acetyl adenylate. The levels of acetylation depend on both pH and on reagent concentration.
RAMPONI, GIAMPIETRO, MANAO, GIAMPAOLO, CAMICI, GUIDO   +2 more
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Histone Acetylation and Gastrointestinal Carcinogenesis

Annals of the New York Academy of Sciences, 2003
Abstract: The importance of altered histone acetylation in gastrointestinal carcinogenesis, especially in relation to invasion and metastasis, is described. Histone acetylation and chromatin remodeling linked with CpG island methylation play a major role in epigenetic regulation of gene expression.
Wataru, Yasui, Naohide, Oue, Shigehiro, Ono, Yoshitsugu, Mitani, Reiko, Ito, Hirofumi, Nakayama   +5 more
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Histone acetylation and X inactivation

Developmental Genetics, 1998
In mammals, the levels of X-linked gene products in males and females are equalised by the silencing, early in development, of most of the genes on one of the two female X chromosomes. Once established, the silent state is stable from one cell generation to the next. In eutherian mammals, the inactive X chromosome (Xi) differs from its active homologue
A M, Keohane, J S, Lavender, L P, O'Neill, B M, Turner   +3 more
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Histone Acetylation in Insect Chromosomes

Science, 1968
Acetylation of histones takes place along the salivary gland chromosomes of Chironomus thummi when RNA synthesis is active. It can be observed but not measured quantitatively by autoradiography of chromosome squashes.
V G, Allfrey, B G, Pogo, V C, Littau, E L, Gershey, A E, Mirsky   +4 more
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Histone Acetylation and Chromatin Remodeling

Experimental Cell Research, 2001
Chromatin represents a repressive barrier to the process of transcription. This molecular obstacle is a highly dynamic structure, able to compact the DNA of the entire genome into the confines of a nucleus, and yet it allows access to the genetic information held within.
P D, Gregory, K, Wagner, W, Hörz
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Temporal changes in histone acetylation

Mechanisms of Ageing and Development, 1978
The incorporation of tritiated acetate was studied in developing and aging rats. Thymus, liver and serum were collected 30 minutes after injection of acetate. The trichloroacetic acid precipitable histone fraction was then extracted from liver and thymus and its radioactivity determined. Serum and cytoplasmic fractions were also counted. Serum activity
M, Petricevic, C W, Denko, L, Messineo
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Histone Acetylation and Plant Development

2016
Reversible histone acetylation and deacetylation at the N-terminus of histone tails play a crucial role in regulation of gene activity. Hyperacetylation of histones relaxes chromatin structure and is associated with transcriptional activation, whereas hypoacetylation of histones induces chromatin compaction and gene repression.
X, Liu, S, Yang, C-W, Yu, C-Y, Chen, K, Wu   +4 more
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DNA methylation models histone acetylation

Nature, 1998
One of the main determinants of chromatin structure is histone acetylation1. Local chromosomal acetylation can be regulated dynamically, both through the involvement of transactivating factors with intrinsic histone acetylase activity, and through the recruitment of deacetylase complexes that repress gene expression2.
Eden, S., Hashimshony, I., Keshet, H., Cedar, H., Thorne, Alan   +4 more
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Targeting Histone Acetylation

2015
Histone acetylation is the most widespread and pleiotropic of all histone modifications. Initially it was believed to alter gene expression simply by altering the physical compaction of chromatin but it is now recognised that the effects are far more subtle and varied than this.
Daniel Vitt, Roland Baumgartner, Hella Kohlhof   +2 more
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