Results 121 to 130 of about 42,139 (259)

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof‐of‐Concept Synthesis of Landscape‐Level Regulation

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Oncogenic condensates act as biophysical sanctuaries that stabilize malignant survival programs. However, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive.
Doris Loh, Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Russel J. Reiter   +3 more
wiley   +1 more source

Histone acetyltransferase KAT6A contributes to colon cancer malignant progression by inhibiting ferroptosis. [PDF]

BMC Cancer
Huo J, Chen H, Zhang X, Sun D, Sheng H, Jiang Y.   +5 more
europepmc   +1 more source

Reframing Wnt/β‐Catenin Signalling in Liver Fibrosis: Transcriptional State Regulation by CBP and p300

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Liver fibrosis is a shared pathological phenotype of chronic liver diseases of diverse etiologies, including viral hepatitis, alcohol‐associated liver disease and metabolic dysfunction–associated steatohepatitis (MASH), as well as cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis, and may ...
Kiminori Kimura, Michinori Kohara
wiley   +1 more source

Mechanistic insights into histone recognition and H3K14 acetylation by the NuA3 histone acetyltransferase complex. [PDF]

Nat Commun
Shi W, Zhao L, Wang Y, Zhang Y, Liu S, Wang Y, Kornberg RD, Zhang H.   +7 more
europepmc   +1 more source

An N‐acetyltransferase‐MAPK fusion protein modulates developmental reprogramming in Physcomitrium patens

New Phytologist, Volume 251, Issue 1, Page 321-339, July 2026.
Summary We discovered a previously uncharacterized moss‐specific protein, Rosetta NATD‐MAPK 1 (RAK1) in Physcomitrium patens, which uniquely integrates MAP kinase (MAPK)‐dependent signaling with N‐acetyltransferase activity. Through phenotypical and biochemical analyses, we characterized RAK1 function in the regulation of the 2D‐to‐3D growth transition.
Cloe de Luxán‐Hernández, Thomas J. Ammitsøe, Jakob V. Kanne, Sabrina Stanimirovic, Rocío Redondo‐Rodríguez, Milena E. Roux, Liechi Zhang, Zoe Weeks, Michael Schutzbier, Gerhard Dürnberger, Elisabeth Roitinger, Oliver Spadiut, Masaki Ishikawa, Mitsuyasu Hasebe, Laura A. Moody, Yasin F. Dagdas, Eleazar Rodriguez, Morten Petersen   +17 more
wiley   +1 more source

Identification and functional characterization of the histone acetyltransferase gene family in Bursaphelenchus xylophilus. [PDF]

BMC Genomics
Wang L, Song Y, Sheng R, Latif MF, Xu M, Wang Y, Li M, Chen F.   +7 more
europepmc   +1 more source

Comprehensive Biophysical Profiling Evidences Self‐Oligomerization of Bacterially Expressed Pc Protein

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Polycomb (Pc), a core component of Polycomb Repressive Complex 1 (PRC1), is largely intrinsically disordered yet forms buffer‐ and concentration‐dependent higher‐order assemblies. Integrative biophysical analysis and cryo‐electron microscopy reveal dynamic, heterogeneous oligomers, whereas AlphaFold modeling suggests that structural organization is ...
Maria Zahid, Sabin Prajapati, Ghazaleh Alamdari, Kai Tittmann, Selin Kara   +4 more
wiley   +1 more source

Structure of the transcriptional co-activator SAGA complex, including the histone acetyltransferase module. [PDF]

Mol Cell
Mattoo RUH, Chen DH, Bushnell DA, Tamir S, Kornberg RD.   +4 more
europepmc   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

The MYST Family Histone Acetyltransferase SasC Governs Diverse Biological Processes in Aspergillus fumigatus. [PDF]

Cells, 2023
Kwon JY, Choi YH, Lee MW, Yu JH, Shin KS.   +4 more
europepmc   +1 more source