Genetic code expansion for chemosensing and chemical actuation of biological functions
Bulletin of the Korean Chemical Society, EarlyView.Genetic code expansion (GCE) broadens the chemical repertoire for precise control of protein function in biological systems. This review highlights GCE‐based sensing and actuating systems that operate through selective interactions between noncanonical amino acids and chemical triggers.
Jieun Bae, Dong‐Hyun Kim, Minseob Koh
wiley +1 more source
Transcriptional regulation of human topoisomerase II beta : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]
, 2006 Pages 24 and 25 are missing from the original copy.Topoisomerase II has an essential role in maintaining the DNA in the correct topological state required for various cellular processes.
Mawson, Claire
core
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
Isolation and Partial Charcterization of Three Histone-Specific Acetyltransferases form Artemia [PDF]
, 1983 Inmaculada Estepa, Ángel Pestaña
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Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
The Role of Histone Acetyltransferases and Histone Deacetylases in Photoreceptor Differentiation and Degeneration [PDF]
, 2020 Meng Zhao, Ye Tao, Guang-Hua Peng
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Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
Nature Communications, 2017 A substantial obstacle in basic research is the use of poorly validated tool compounds with purported useful biological functions. Here, the authors systematically profile widely used histone acetyltransferase inhibitors and find that the majority are ...
Jayme L. Dahlin +14 more
doaj +1 more source
Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity
eLife, 2016 Salicylate and acetylsalicylic acid are potent and widely used anti-inflammatory drugs. They are thought to exert their therapeutic effects through multiple mechanisms, including the inhibition of cyclo-oxygenases, modulation of NF-κB activity, and ...
Kotaro Shirakawa +14 more
doaj +1 more source
A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation [PDF]
, 2016 Cheng‐Guo Duan +17 more
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Regulation of Chromatin Assembly/Disassembly by Rtt109p, a Histone H3 Lys56-specific Acetyltransferase, in Vivo [PDF]
, 2010 Geetha Durairaj +5 more
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