Results 131 to 140 of about 391,128 (337)

Enzyme kinetics and inhibition of histone acetyltransferase KAT8

European journal of medicinal chemistry, 2015
Lysine acetyltransferase 8 (KAT8) is a histone acetyltransferase (HAT) responsible for acetylating lysine 16 on histone H4 (H4K16) and plays a role in cell cycle progression as well as acetylation of the tumor suppressor protein p53.
H. Wapenaar, Petra E. van der Wouden, M. Groves, D. Rotili, A. Mai, F. Dekker   +5 more
semanticscholar   +1 more source

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brain

Life Science Alliance
Heterozygous mutations in the MYST family histone lysine acetyltransferase, KAT6B, cause intellectual disability disorders. This study identifies the histone and gene targets of KAT6B which include SOX2, a master regulator of neural stem and progenitor ...
Maria I Bergamasco, Waruni Abeysekera, Alexandra L Garnham, Yifang Hu, Connie SN Li-Wai-Suen, Bilal N Sheikh, Gordon K Smyth, Tim Thomas, Anne K Voss   +8 more
doaj   +1 more source

Molecular basis for histone acetyltransferase regulation by binding partners, associated domains, and autoacetylation

ACS Chemical Biology, 2015
Acetylation is a post-translational modification (PTM) that regulates chromatin dynamics and function. Dysregulation of acetylation or acetyltransferase activity has been correlated with several human diseases. Many, if not all histone acetyltransferases
C. McCullough, R. Marmorstein
semanticscholar   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion.

Cell Metabolism
Lactyl-coenzyme A (CoA)-dependent histone lysine lactylation impacts gene expression and plays fundamental roles in biological processes. However, mammalian lactyl-CoA synthetases and their regulation of histone lactylation have not yet been identified ...
Rongxuan Zhu, Xianglai Ye, Xiao-Tong Lu, Li-Wei Xiao, Ming Yuan, Hong Zhao, Dong Guo, Ying Meng, Hongkuan Han, Shu-Di Luo, Qingang Wu, Xiaoming Jiang, Jun Xu, Zhonghui Tang, Y. J. Tao, Zhi-Min Lu   +15 more
semanticscholar   +1 more source

Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. [PDF]

, 2010
Methylation of residues in histone tails is part of a network that regulates gene expression. JmjC domain containing proteins catalyze the oxidative removal of methyl groups on histone lysine residues.
Erck, C, Böttger, Angelika, Burrells Alison, Andreas Lengeling, Butler, Danica, Hahn, P., Erck, Christian, Wolf, A., Lengeling, A., Bottger, A., Jens Böse, Erck, C., Christopher J Schofield, Hahn, P, Wegener, Ivonne, Wegener Ivonne, Böse, Jens, Christian Erck, Angelika Böttger, Burrells, A, Ivonne Wegener, Butler, D, Butler Danica, Lengeling Andreas, Böse Jens, Burrells, A., Alexander Wolf, Hahn Phillip, Wolf, A, Bose, J., Lengeling, A, Erck Christian, Böttger Angelika, Danica Butler, Phillip Hahn, Butler, D., Wolf Alexander, Hahn, Phillip, Wolf, Alexander, Schofield, Christopher J, Alison Burrells, Schofield Christopher J., Böse, J, Lengeling, Andreas, Schofield, Christopher J., Wegener, I, Schofield, CJ, Wegener, I., Burrells, Alison, Schofield, Christopher, Böttger, A, Christopher J. Schofield   +51 more
core   +2 more sources

Modulation of Epigenetic Control by Advanced Molecular Tweezers

Chemistry – A European Journal, EarlyView.
Tailored dimeric molecular tweezers recognize the DNA‐binding part of Histone H4 and interrupt the essential histone‐DNA interaction. ABSTRACT This work addresses the question if supramolecular systems can be tailored to interfere with posttranslational modifications (PTM) and epigenetics.
My‐Hue‐Le, Bianca Kamba, Anja Matena, Christine Beuck, Victoria Momand, Spiros Salvanos, Jessica Vossen, Mike Blueggel, Thomas Schrader, Peter Bayer   +9 more
wiley   +1 more source

Azide-alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase PCAF [PDF]

, 2014
A novel strategy to prepare bisubstrate based inhibitors for histone acetyltransferases is presented. To obtain these, azido peptides derived from histone H3 incorporating either a serine or a phosphoserine residue were connected to a propargyl coenzyme ...
Liskamp, Rob M J, van Ameijde, Jeroen, Liskamp, Rob M. J., Molecular Pharmacy, Zwiebel, Addy P R, Ruijtenbeek, Rob, Zwiebel, Addy P. R., Sub Medicinal Chemistry & Chemical biol.   +7 more
core   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source