Results 141 to 150 of about 42,139 (259)

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

Histone acetyltransferase 1 promotes ovarian cancer progression by regulating cell proliferation and the cell cycle. [PDF]

Oncol Lett
Han X, Liu L, Li J, Zhi Y, Zhao L, Yuan L, Ouyang X, Liu J.   +7 more
europepmc   +1 more source

Integrative analysis of histone acetyltransferase KAT2A in human cancer. [PDF]

Cancer Biomark, 2023
Li H, Li C, Yang LZ, Liu J.
europepmc   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Enhancement of <i>Monascus</i> Azaphilone Pigments Production Without Citrinin Contamination by Targeting Overexpression of Histone Acetyltransferase MrEsa1 and Deletion of Polyketide Synthase PksCT. [PDF]

J Fungi (Basel)
Zhang J, Yang S, Wang Q, Liu Q, Chen J, Gong Y, Xu R, Shao Y.   +7 more
europepmc   +1 more source

Histone Acetyltransferase Rtt109 Regulates Development, Morphogenesis, and Citrinin Biosynthesis in Monascus purpureus. [PDF]

J Fungi (Basel), 2023
Shi R, Gong P, Luo Q, Chen W, Wang C.
europepmc   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, Volume 13, Issue 32, 9 June 2026.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

Expression of Concern: Histone acetyltransferase inhibition reverses opacity in rat galactose-induced cataract. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Histone Acetyltransferase KAT6A [PDF]

, 2020
openaire   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, Volume 13, Issue 31, 4 June 2026.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source