Results 161 to 170 of about 42,139 (259)

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

<i>Arabidopsis</i> HOOKLESS1 acts as a histone acetyltransferase to promote cotyledon greening during seedling de-etiolation. [PDF]

Proc Natl Acad Sci U S A
Peng Y, Peng T, Chu Y, Yan W, Yao R, Wen X, Qiu Y, Wang M, Xiao Z, Zhang D, Chen X, Yin Z, Wang Y, Guo H.   +13 more
europepmc   +1 more source

Histone Acetyltransferase p300 [PDF]

, 2020
openaire   +1 more source

Epigenetically driven impairment of BDNF–ARC signaling contributes to circadian and cognitive disarray in a mouse model of postoperative delirium

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Postoperative delirium (POD) is common in older surgical patients and is clinically associated with an increased risk of long‐term cognitive decline and dementia; disrupted BDNF signaling and circadian dysregulation are implicated, but their coordinated mechanisms remain unclear.
Hari Prasad Osuru, Navya Atluri, Tam Le, Jinny Park, Michal Jedrusiak, Elzbieta Dulko, Meghana Illendula, Nadia Lunardi   +7 more
wiley   +1 more source

Histone acetyltransferase HAF2 associates with pyruvate dehydrogenase complex to control H3K14ac and H3K23ac in ethylene response. [PDF]

Cell Rep
Chen CY, Shao Z, Wang G, Zhao B, Hardtke HA, Leong J, Zhou T, Zhang YJ, Qiao H.   +8 more
europepmc   +1 more source

Histone Acetyltransferase KAT2B [PDF]

, 2020
openaire   +1 more source

Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer-factor-mediated zygotic genome activation. [PDF]

Mol Cell
Marsh AJ, Pirogov S, Kaur Y, Ruffridge AJ, Sajwan S, Gibson TJ, Hunt G, Harrison MM, Mannervik M.   +8 more
europepmc   +1 more source

Histone Acetyltransferase KAT5 [PDF]

, 2020
openaire   +1 more source

Synergistic Antitumor Activity of HAT Inhibitor A485 and XPO1 Inhibitor KPT8602 in Multiple Myeloma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Multiple myeloma (MM) remains the second most common hematologic malignancy, necessitating the identification of novel therapeutic targets. MM is characterized by a distinct epigenetic landscape driven by aberrant chromatin activation and super‐enhancer addiction.
Hong Xu, Wenqi Wu, Yanan Jiang, Jinhuan Wang, Yixin Zhai, Zhigang Zhao   +5 more
wiley   +1 more source

Histone acetyltransferase GCN5 orchestrates flower development and is required for proper regulation of multiple key meristem and organ identity genes. [PDF]

Plant Cell
Wang J.
europepmc   +1 more source