Results 161 to 170 of about 391,128 (337)

Epigenetic dynamics of Helicobacter pylori-induced COX-2 activation [PDF]

, 2009
Background and Aims: Cyclooxigenase (COX)-2 is over expressed in gastrointestinal neoplasia and Helicobacter pylori (H. pylori) infection is casually linked to gastric cancer. We undertook this study to investigate the mechanism mediating H.
Peluso, Silvia
core   +1 more source

Yeast Nat4 regulates DNA damage checkpoint signaling through its N-terminal acetyltransferase activity on histone H4.

PLoS Genetics
The DNA damage response (DDR) constitutes a vital cellular process that safeguards genome integrity. This biological process involves substantial alterations in chromatin structure, commonly orchestrated by epigenetic enzymes.
Mamantia Constantinou, Evelina Charidemou, Izge Shanlitourk, Katerina Strati, Antonis Kirmizis   +4 more
doaj   +1 more source

Analysis of p300/CBP Histone Acetyltransferase Regulation Using Circular Permutation and Semisynthesis

, 2016
Analysis of p300/CBP Histone Acetyltransferase Regulation Using Circular Permutation and ...
Lerna Uzasci (1333521), Qing Wang (27728), Cara Marie Manlandro (2321656), Kannan R. Karukurichi (2321653), Philip A. Cole (1310328), Ling Wang (56577)   +5 more
core   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

3D structure prediction of histone acetyltransferase (HAC) proteins of the p300/CBP family and their interactome in Arabidopsis thaliana [PDF]

, 2014
Histone acetylation is an important posttranslational modification correlated with gene activation. In Arabidopsis thaliana the histone acetyltransferase (HAC) proteins of the CBP family are homologous to animal p300/CREB (cAMP-responsive element-binding
Jasmin Sutkovic, Amar Cemanovic, Rabab Elamawi, et al.   +2 more
core  

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Characterization of Gcn5 histone acetyltransferase in Schizosaccharomyces pombe

, 2009
The organisation of eukaryotic DNA into chromatin provides a natural barrier that prevents full access to the DNA thereby inhibiting events such as transcription, replication and repair. In order for these DNA-related events to occur, the chromatin needs
Anna Johnsson (226783)
core   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF

, 2010
The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid ...
FA', MAURO, FRANCIS Y., FENG Y, DENG S, ARANCIO O, LANDRY DW   +5 more
core