Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases
The FEBS Journal, EarlyView.Cortactin function is regulated by acetylation at several lysine residues within its tandem repeat region. Using genetic code expansion to generate cortactin variants containing precisely defined acetylation marks, we show that HDAC6 is the primary enzyme removing these modifications, with SIRT1 and SIRT2 also acting at selected sites but with lower ...
Jan Komarek +12 more
wiley +1 more source
Dietary polyphenols mediated regulation of oxidative stress and chromatin remodeling in inflammation [PDF]
, 2008 Aggarwal +20 more
core +1 more source
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
The FEBS Journal, EarlyView.TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
Tax abolishes histone H1 repression of p300 acetyltransferase activity at the HTLV-1 promoter
, 2006 Kasey L. Konesky +5 more
openalex +2 more sources
Journal of Integrative Plant Biology, EarlyView.The transcriptional adapter ADA2 interacts with the histone acetyltransferase GCN5 to regulate starch and storage protein content in wheat grains through histone acetylation. ADA2 undergoes phase separation and is modulated by GCN5, affecting histone acetyltransferase activity and gene transcription.
Xiaobang Zhang +15 more
wiley +1 more source
IL-1β–specific recruitment of GCN5 histone acetyltransferase induces the release of PAF1 from chromatin for the de-repression of inflammatory response genes [PDF]
, 2013 Nari Kim +3 more
openalex +1 more source
Mammalian histone acetyltransferase complexes.
Medicina, 2001 Over the last decade, great progress has been made in elucidating how the human genome operates in the chromatin context. This paper describes our work on two human acetyltransferases, PCAF and TIP60, and their interaction partners. This study provides new clues on the function of these enzymes.
openaire +1 more source
Epigenetic Regulation in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch +3 more
wiley +1 more source
PWO proteins are associated with PRC2 since their emergence in vascular plants
New Phytologist, EarlyView.Summary The Polycomb repressive complex 2 (PRC2), a conserved histone methyltransferase complex, plays a central role in transcriptional silencing across eukaryotes. Here, we investigate the evolution of PWWP‐DOMAIN INTERACTORS OF POLYCOMBS (PWOs), which interact with PRC2, and examine the conservation of the PWOs‐PRC2 interaction across plant ...
Ahamed Khan +11 more
wiley +1 more source
Histone Acetyltransferase and Deacetylase Inhibitors-New Aspects and Developments. [PDF]
Int J Mol Sci, 2023 Ibrahim HS, Sippl W.
europepmc +1 more source