Results 171 to 180 of about 42,139 (259)

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source

Tissue-specific localization of the ING4 targeting subunit of the HBO1 histone acetyltransferase in the cytoplasm and nucleus of secretory cells. [PDF]

Histochem Cell Biol
Dantas A, Shueili BA, Park J, Abdullah S, Bertschmann J, Krowicki H, Djamshidi M, Yang Y, Blote K, Thalappilly S, Riabowol K.   +10 more
europepmc   +1 more source

Lysine lactylation‐mediated post‐translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Lysine lactylation (Kla) serves as a metabolic–epigenetic switch governed by writer–eraser–reader regulatory systems, directly connecting the Warburg effect to diverse forms of tumour drug resistance. Intratumoural lactylation critically contributes to treatment failure in chemotherapy, targeted therapy and immunotherapy.
Juan Li, Yan Shang, Haojie Wu, Shenglong Yang, Maiqun Zuo, Hailong Zhao   +5 more
wiley   +1 more source

Histone Acetyltransferase MOF-Mediated AURKB K215 Acetylation Drives Breast Cancer Cell Proliferation via c-MYC Stabilization. [PDF]

Cells
Miao Y, Zhang N, Li F, Wang F, Chen Y, Li F, Cui X, Zhao Q, Cai Y, Jin J.   +9 more
europepmc   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Jiajun Qiao, Yue Xiao, Yi Cheng, Weihai Xu, Jing Shu, Shishi Li   +5 more
wiley   +1 more source

Design of a Bioluminescent Assay Platform for Quantitative Measurement of Histone Acetyltransferase Enzymatic Activity. [PDF]

Chembiochem
Swain ND, George Zheng Y.
europepmc   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Identification of the histone acetyltransferase gene family in the Artemisia annua genome. [PDF]

Front Plant Sci
Guo Y, You Y, Chen F, Liao Y.
europepmc   +1 more source

T Cell Exhaustion as a Regulated Differentiation Programme

European Journal of Immunology, Volume 56, Issue 6, June 2026.
This review highlights T cell exhaustion as an adaptive differentiation trajectory, not dysfunction, showing how precursor, intermediate, and terminal exhausted states maintain antigen recognition while limiting tissue damage in chronic immune activation.
Marc Veldhoen, Cristina Ferreira
wiley   +1 more source

Selective Recruitment of a Synthetic Histone Acetyltransferase Can Boost CHO Cell Productivity. [PDF]

Biotechnol J
Butterfield SP, Sizer RE, Saunders FL, White RJ.   +3 more
europepmc   +1 more source