Results 191 to 200 of about 391,128 (337)

Characterization of Gcn5 histone acetyltransferase in Schizosaccharomyces pombe [Elektronisk resurs]

, 2009
The organisation of eukaryotic DNA into chromatin provides a natural barrier that prevents full access to the DNA thereby inhibiting events such as transcription, replication and repair. In order for these DNA-related events to occur, the chromatin needs
Johnsson, A
core  

CCNE1: A Cell Cycle Regulator That Influences Tumor Progression

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Liang Yan, Siyi Liu, Yanling Li, Qian He, Chen Long, Ning Tang, Yanhong Zhou   +6 more
wiley   +1 more source

A role for the poly-asparagine repeat in the Plasmodium histone acetyltransferase, PfGCN5. [PDF]

Nat Commun
Rubiano K, Morris A, Vitorino FDL, Travis J, Garcia BA, Mukherjee S, Goldberg DE.   +6 more
europepmc   +1 more source

Nicotinamide and Sodium Butyrate Double the Pool of Treatment‐Exclusive Metabolites in the Endophytic Fungus Curvularia sp. G6‐32

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Epigenetic modulators nicotinamide and sodium butyrate reshape the chemical landscape of the endophytic fungus Curvularia sp. G6‐32. Combining the OSMAC strategy with UHPLC‐MS/MS metabolomics and molecular networking reveals a more than twofold rise in treatment‐exclusive metabolites, including diketopiperazines and potentially bioactive natural ...
Guilherme Edison Almeida Pega, Laís Stella Perassolli Nicchio, Andressa Domingos Polli, Francielli Alana Pereira Valeze, Évelin Lemos de Oliveira, Eduardo Cesar Meurer, Débora Cristina Baldoqui, João Lúcio Azevedo, Julio Cesar Polonio   +8 more
wiley   +1 more source

Epigenetic Regulation of Cotton Plant Height by Histone Acetyltransferase GhHAT11 via Hormonal Pathway Modulation. [PDF]

Physiol Plant
Zhang X, Zhong X, Li Y, Liusui Y, Fu W, Wang Z, Huang G, Zhang J, Guo Y, Li B.   +9 more
europepmc   +1 more source

Targeting Microglial HDAC5 Suppresses NLRP3 Inflammation via NF‐κB Deacetylation to Alleviate Ischemic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Cerebral ischemia/reperfusion induced HDAC5 upregulation in microglia. Elevated HDAC5 promoted NLRP3‐mediated neuroinflammation via NF‐κB p65 deacetylation. RGD‐EV:miR‐9‐5p delivery suppressed microglial HDAC5 and attenuated ischemic brain injury. ABSTRACT Objective Histone deacetylases are implicated in ischemic stroke, yet the role of HDAC5 remains ...
Ru‐Yu Liang, Jia‐Qi Zhang, Tian‐Yi Jiang, Li‐Qing Tao, Wen She, Zhou‐Na Sun, Cui Qi, Jun Gao   +7 more
wiley   +1 more source

ATR-dependent phosphorylation of the histone acetyltransferase HBO1 suppresses chromatin binding and promotes replication stress responses. [PDF]

J Biol Chem
Zong C, Zhang J, Zhang Z, Cai Y, Wang Y, Fang Y, Zheng G, Li Q, Wang L, Shen J.   +9 more
europepmc   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Schistosoma japonicum histone acetyltransferase 1 (SjHAT1): A novel anti-schistosomal drug target. [PDF]

PLoS Pathog
Xu J, Wang YX, Huang P, Zhang YN, Sun H, Zhan TZ, Xia CM.   +6 more
europepmc   +1 more source

Citrus depressa peel extract and its polymethoxyflavones mitigate acetaminophen‐induced chronic liver injury in mice through antioxidant activation, epigenetic regulation, and gut microbiota modulation

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7629-7642, October 2026.
Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai, Zi‐Han Lin, Guor‐Jien Wei, Liang‐Yi Wu, Tien‐Yuan Wu, Yen‐Chen Tung, Ssu‐Han Huang, Zheng‐Yuan Su   +7 more
wiley   +1 more source