Results 191 to 200 of about 42,139 (259)

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

Correction to "Alignment of Human KAT2A (GCN5) Histone Acetyltransferase and SARS-CoV-2 Orf8 Viral Proteins". [PDF]

Chronic Dis Transl Med
europepmc   +1 more source

ATAC and SAGA histone acetyltransferase modules facilitate transcription factor binding to nucleosomes independent of their acetylation activity. [PDF]

Nucleic Acids Res
Chesnutt KV, Yayli G, Toelzer C, Damilot M, Cox K, Gautam G, Berger I, Tora L, Poirier MG.   +8 more
europepmc   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

The transcription factor CAMTA2 interacts with the histone acetyltransferase GCN5 and regulates grain weight in wheat. [PDF]

Plant Cell
Zhang R, An K, Gao Y, Zhang Z, Zhang X, Zhang X, Rossi V, Cao Y, Xiao J, Xin M, Du J, Hu Z, Liu J, Peng H, Ni Z, Sun Q, Yao Y.   +16 more
europepmc   +1 more source

ATAC and SAGA histone acetyltransferase modules facilitate transcription factor binding to nucleosomes in an acetylation independent manner

, 2023
Chesnutt K, Yayli G, Toelzer C, Cox K, Gautam G, Berger I, Tora L, Poirier MG.   +7 more
europepmc   +1 more source

Stearoyl‐CoA Desaturase‐1 Drives Tumor Growth by Interacting With Histone Deacetylase‐2 and Deacetylating Nucleophosmin‐1

MedComm, Volume 7, Issue 6, June 2026.
Hypoxia induces SCD1 and PLIN2 to drive lipid droplet‐dependent metabolic adaptation in cancer cells. PLIN2 supports survival under stress, whereas SCD1 promotes proliferation upon reoxygenation and remodels the acetylome via HDAC2‐mediated NPM1 deacetylation and destabilization.
Coline Wery, Laetitia Montero‐Ruiz, Eric Bonneil, Mohammad Farran, Robin Jehay, Quentin Herrara Garfia, Gregory Fettweis, Silvia Blacher, Charles Pottier, Gael Cobraiville, Yasmine Boumahd, Olivier Peulen, Agnès Noël, Franck Dequiedt, Marianne Fillet, Nor Eddine Sounni   +15 more
wiley   +1 more source

Epigenetic control of SOX9 gene by the histone acetyltransferase P300 in human Sertoli cells. [PDF]

Heliyon
González D, Peña MJ, Bernal C, García-Acero M, Manotas MC, Suarez-Obando F, Rojas A.   +6 more
europepmc   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, Volume 2, Issue 2, Page 236-279, June 2026.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Negative regulation of HDAC3 transcription by histone acetyltransferase TIP60 in colon cancer. [PDF]

Genes Genomics
Lee SY, Park J, Seo SB.
europepmc   +1 more source