Results 61 to 70 of about 391,128 (337)
, 2021 In eukaryotes, CREB-binding protein (CBP), a coactivator of CREB, functions both as a platform for recruiting other components of the transcriptional machinery and as a histone acetyltransferase (HAT) that alters chromatin structure. We previously showed
Kemenes, I. +12 more
core +1 more source
The Major Cytoplasmic Histone Acetyltransferase in Yeast: Links to Chromatin Replication and Histone Metabolism [PDF]
, 1996 We have isolated the predominant cytoplasmic histone acetyltransferase activity from Saccharomyces cerevisiae. This enzyme acetylates the lysine at residue 12 of free histone H4 but does not modify histone H4 when packaged in chromatin.
Parthun, Mark R +2 more
core +1 more source
Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Regulating gene expression is critical to the normal function of a biological cell, and misregulation of gene expression often leads to a diseased cell.
Jian Sun +9 more
semanticscholar +1 more source
Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals [PDF]
BioEssays, 2018 Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair. Histone acetyltransferases were initially identified as co‐activators that link DNA‐binding transcription factors to the general ...
Voss, AK, Thomas, T
openaire +3 more sources
Histone chaperone exploits intrinsic disorder to switch acetylation specificity
Nature Communications, 2019 Histone chaperones have been shown to control the activity and specificity of histone-modifying enzymes. Here the authors establish a structural model of the acetyltransferase Rtt109 in complex with Asf1 and Vps75 and the histone dimer H3:H4, finding ...
Nataliya Danilenko +5 more
doaj +1 more source
mSphere, 2023 Sexual reproduction is the primary driving force behind eukaryotic environmental adaptation and evolution. In the human fungal pathogen Cryptococcus neoformans, sexual reproduction plays a critical role in the emergence of highly virulent strains and ...
Man Chen +9 more
doaj +1 more source
Distinct patterns of histone acetyltransferase and Mediator deployment at yeast protein-coding genes
Genes & Development, 2018 Here, Bruzzone et al. explore the relative contributions of the transcriptional coactivators Mediator and two histone acetyltransferase (HAT) complexes, NuA4 and SAGA, to RNA polymerase II association at specific genes and gene classes by rapid nuclear ...
M. Bruzzone +4 more
semanticscholar +1 more source
MYST3 (MYST histone acetyltransferase (monocytic leukemia) 3 [PDF]
, 2006 Review on MYST3 (MYST histone acetyltransferase (monocytic leukemia) 3, with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL, Senon, S
core +1 more source
BMC Genomics, 2010 Background Histone acetyltransferase enzymes (HATs) are implicated in regulation of transcription. HATs from different families may overlap in target and substrate specificity.
Wright Anthony PH +7 more
doaj +1 more source
Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy
Frontiers in Oncology, 2020 Evidence for research over the past decade shows that epigenetic regulation mechanisms run through the development and prognosis of tumors. Therefore, small molecular compounds targeting epigenetic regulation have become a research hotspot in the ...
Donglu Wu +8 more
doaj +1 more source