Results 51 to 60 of about 391,128 (337)

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Rice Homeodomain Protein WOX11 Recruits a Histone Acetyltransferase Complex to Establish Programs of Cell Proliferation of Crown Root Meristem[OPEN]

The Plant Cell, 2017
Rice WOX11 promotes crown root development by interacting with a histone acetylation complex to induce permissive chromatin of gene expression. Shoot-borne crown roots are the major root system in cereals. Previous work has shown that the Wuschel-related
Shaoli Zhou, Wei Jiang, F. Long, Saifeng Cheng, Wenjing Yang, Yu Zhao, Dao-Xiu Zhou   +6 more
semanticscholar   +1 more source

Gcn5: The Quintessential Histone Acetyltransferase [PDF]

, 2020
In this Special Issue, we bring together many of the original researchers involved in the initial studies to identify and characterize Gcn5, together with leaders from the field who have contributed to our understanding of this quintessential histone ...
Weake, Vikki M
core   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

MOF Regulates TNK2 Transcription Expression to Promote Cell Proliferation in Thyroid Cancer

Frontiers in Pharmacology, 2020
MOF is a well-known histone acetyltransferase to catalyze acetylation of histone H4 lysine 16 (K16), and it is relevant to diverse biological processes, such as gene transcription, cell cycle, early embryonic development and tumorigenesis.
Danyang Li, Danyang Li, Yang Yang, Yang Yang, Bo Chen, Xinghong Guo, Xinghong Guo, Shuang Gao, Meng Wang, Mingxiao Duan, Xiangzhi Li   +10 more
doaj   +1 more source

Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls

G3: Genes, Genomes, Genetics, 2023
Covalent modifications of chromatin regulate genomic structure and accessibility in diverse biological processes such as transcriptional regulation, cell cycle progression, and DNA damage repair.
Qihao Liu, Lorraine Pillus, Emily L Petty   +2 more
doaj   +1 more source

Histone acetyltransferase KAT6A upregulates PI3K/AKT signaling through TRIM24 binding

Cancer Research, 2017
Lysine acetyltransferase KAT6A is a chromatin regulator that contributes to histone modification and cancer, but the basis of its actions are not well understood.
D. Lv, Feng Jia, Yan-Li Hou, Y. Sang, A. Alvarez, Weiwei Zhang, Wei-Qiang Gao, Bo Hu, Shi-Yuan Cheng, J. Ge, Yan-Xin Li, H. Feng   +11 more
semanticscholar   +1 more source

H3 K36 Methylation Helps Determine the Timing of Cdc45 Association with Replication Origins [PDF]

, 2009
BackgroundReplication origins fire at different times during S-phase. Such timing is determined by the chromosomal context, which includes the activity of nearby genes, telomeric position effects and chromatin structure, such as the acetylation state of ...
Mariotti, F.R., Maria Vogelauer, Francesca Romana Mariotti, Devanshi Jain, Pryde, F., Jain, D., Alastair Kerr, Kerr, A., Rebecca Curley, Curley, R., Vogelauer, M., Fiona Pryde   +11 more
core   +2 more sources

Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression [PDF]

, 2009
The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. These proteins contain two related domains known as the chromo- and the chromoshadow-domain.
Fan Hua-Ying, Kingston Robert E., Violaine Saint-André, Christian Muchardt, Saint-Andre, Violaine, Imhof Axel, Batsché Eric, Jang Suk Min, Kingston, Robert E., Saliha Azebi, Robert E Kingston, Axel Imhof, Jang, Suk Min, Eskeland, Ragnhild, Eskeland Ragnhild, Muchardt Christian, Eric Batsché, Azebi Saliha, Fan, Hua-Ying, Muchardt, Christian, Batsche, Eric, Hua-Ying Fan, Marc Lavigne, Ragnhild Eskeland, Saint-André Violaine, Imhof, Axel, Lavigne, Marc, Azebi, Saliha, Suk Min Jang, Lavigne Marc   +29 more
core   +2 more sources

Phase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation

Communications Biology, 2021
Yang et al find that phase separation of the Epstein-Barr virus nuclear antigen 2 (EBNA2) is involved in the formation of accessible chromatin domains of the host genome.
Yiting Yang, Xidong Ye, Ranran Dai, Zhaoqiang Li, Yan Zhang, Wei Xue, Yongchang Zhu, Delong Feng, Litao Qin, Xin Wang, Bo Lei, Shixiu Liao, Bingtao Hao   +12 more
doaj   +1 more source