Results 31 to 40 of about 42,139 (259)

Histone chaperone exploits intrinsic disorder to switch acetylation specificity

Nature Communications, 2019
Histone chaperones have been shown to control the activity and specificity of histone-modifying enzymes. Here the authors establish a structural model of the acetyltransferase Rtt109 in complex with Asf1 and Vps75 and the histone dimer H3:H4, finding ...
Nataliya Danilenko, Lukas Lercher, John Kirkpatrick, Frank Gabel, Luca Codutti, Teresa Carlomagno   +5 more
doaj   +1 more source

Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation

BMC Genomics, 2010
Background Histone acetyltransferase enzymes (HATs) are implicated in regulation of transcription. HATs from different families may overlap in target and substrate specificity.
Wright Anthony PH, Seidel Chris, Gogol Madelaine, Xue-Franzén Yongtao, Fleharty Brian, Johnsson Anna, Nugent Rebecca L, Forsburg Susan L   +7 more
doaj   +1 more source

Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy

Frontiers in Oncology, 2020
Evidence for research over the past decade shows that epigenetic regulation mechanisms run through the development and prognosis of tumors. Therefore, small molecular compounds targeting epigenetic regulation have become a research hotspot in the ...
Donglu Wu, Donglu Wu, Ye Qiu, Ye Qiu, Yunshuang Jiao, Zhidong Qiu, Zhidong Qiu, Da Liu, Da Liu   +8 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions

Nature Communications
Interleukin-1α is a suggested dual-function cytokine that diverged from interleukin-1β in mammals potentially by acquiring additional biological roles that relate to highly conserved regions in the pro-domain of interleukin-1α, including a nuclear ...
Rose Wellens, Victor S. Tapia, Paula I. Seoane, Hayley Bennett, Antony Adamson, Graham Coutts, Jack Rivers-Auty, Martin Lowe, Jack P. Green, Gloria Lopez-Castejon, David Brough, Christopher Hoyle   +11 more
doaj   +1 more source

Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease

Cells, 2021
Cardiovascular disease is the leading cause of accelerated as well as chronological aging-related human morbidity and mortality worldwide. Genetic, immunologic, unhealthy lifestyles including daily consumption of high-carb/high-fat fast food, lack of ...
Asish K. Ghosh
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Ada2 and Ada3 Regulate Hyphal Growth, Asexual Development, and Pathogenicity in Beauveria bassiana by Maintaining Gcn5 Acetyltransferase Activity

Microbiology Spectrum, 2023
The histone acetyltransferase (HAT) Gcn5 ortholog is essential for a variety of fungi. Here, we characterize the roles of Ada2 and Ada3, which are functionally linked to Gcn5, in the insect-pathogenic fungus Beauveria bassiana.
Shun-Juan Hu, Hao Zheng, Xin-Peng Li, Zhi-Xing Li, Chao Xu, Juan Li, Jia-Hua Liu, Wen-Xiao Hu, Xian-Yan Zhao, Juan-Juan Wang, Lei Qiu   +10 more
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Beyond Wolbachia—Can a small molecule control insect reproduction?

Cell Reports
Kaur et al.1 demonstrate reduced histone acetylation as a key mechanism underpinning Wolbachia’s paternal-effect embryonic lethality trait in Drosophila melanogaster.
Robson Kriiger Loterio, Johanna Elisabeth Fraser   +1 more
doaj   +1 more source