Results 31 to 40 of about 391,128 (337)

Autoacetylation of the Histone Acetyltransferase Rtt109 [PDF]

Journal of Biological Chemistry, 2011
Rtt109 is a yeast histone acetyltransferase (HAT) that associates with histone chaperones Asf1 and Vps75 to acetylate H3K56, H3K9, and H3K27 and is important in DNA replication and maintaining genomic integrity. Recently, mass spectrometry and structural studies of Rtt109 have shown that active site residue Lys-290 is acetylated.
Brittany N, Albaugh, Kevin M, Arnold, Susan, Lee, John M, Denu   +3 more
openaire   +2 more sources

Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs

Journal of Biological Chemistry, 2020
Polyamines regulate gene expression in Escherichia coli by translationally stimulating mRNAs encoding global transcription factors. In this study, we focused on histone acetylation, one of the mechanisms of epigenetic regulation of gene expression, to ...
A. Sakamoto, Yusuke Terui, Takeshi Uemura, K. Igarashi, K. Kashiwagi   +4 more
semanticscholar   +1 more source

Regulating histone acetyltransferases and deacetylases [PDF]

The EMBO Reports, 2003
Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with ...
Gaëlle, Legube, Didier, Trouche
openaire   +2 more sources

Improved drought stress tolerance in Arabidopsis by CRISPR/dCas9 fusion with a Histone AcetylTransferase

Scientific Reports, 2019
Drought episodes decrease plant growth and productivity, which in turn cause high economic losses. Plants naturally sense and respond to water stress by activating specific signalling pathways leading to physiological and developmental adaptations ...
Joaquin Felipe Roca Paixão, F. Gillet, T. Ribeiro, Caroline Bournaud, I. T. Lourenço-Tessutti, D. D. Noriega, Bruno Paes de Melo, J. de Almeida-Engler, M. F. Grossi-de-Sá   +8 more
semanticscholar   +1 more source

Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms

eLife, 2020
Histone acetylation and deposition of H2A.Z variant are integral aspects of active transcription. In Drosophila, the single DOMINO chromatin regulator complex is thought to combine both activities via an unknown mechanism.
Alessandro Scacchetti, Tamas Schauer, Alexander Reim, Zivkos Apostolou, Aline Campos Sparr, Silke Krause, Patrick Heun, Michael Wierer, Peter B Becker   +8 more
doaj   +1 more source

Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. [PDF]

PLoS Genetics, 2013
Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly.
Prabakaran Nagarajan, Zhongqi Ge, Bianca Sirbu, Cheryl Doughty, Paula A Agudelo Garcia, Michaela Schlederer, Anthony T Annunziato, David Cortez, Lukas Kenner, Mark R Parthun   +9 more
doaj   +1 more source

Histone acetyltransferase p300 induces de novo super-enhancers to drive cellular senescence

Molecules and Cells, 2019
Summary Accumulation of senescent cells during aging contributes to chronic inflammation and age-related diseases. While senescence is associated with profound alterations of the epigenome, a systematic view of epigenetic factors in regulating senescence
Payel Sen, Y. Lan, Catherine Y. Li, Simone Sidoli, G. Donahue, Zhixun Dou, Brian Frederick, Qijun Chen, L. J. Luense, B. Garcia, Weiwei Dang, F. Johnson, P. Adams, D. Schultz, S. Berger   +14 more
semanticscholar   +1 more source

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution [PDF]

, 2013
NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a ...
El-Mkami, H., Bowman, A., Dmitri I. Svergun, Hammond, C. M., Hassane El-mkami, Ward, R., David G. Norman, Ward, Richard, Norman, David G., Owen-Hughes, Tom; id_orcid, Svergun, Dmitri, El-Mkami, Hassane, Richard Ward, Stirling, A., Svergun, Dmitri I., Owen-Hughes, Tom, Norman, D. G., Stirling, Andrew, Andrew Stirling, Bowman, Andrew, Shang, Weifeng, Robinson, David A., El Mkami, Hassane, Colin M. Hammond, Andrew Bowman, Hammond, Colin M., Shang, W., Robinson, D. A., David A. Robinson, Weifeng Shang, Tom Owen-hughes, Owen-Hughes, T.   +31 more
core   +1 more source

Diversification of the Histone Acetyltransferase GCN5 through Alternative Splicing in Brachypodium distachyon

Frontiers in Plant Science, 2017
The epigenetic modulatory SAGA complex is involved in various developmental and stress responsive pathways in plants. Alternative transcripts of the SAGA complex's enzymatic subunit GCN5 have been identified in Brachypodium distachyon.
Alexandre Martel, Hardev Brar, Boris F. Mayer, Jean-Benoit Charron   +3 more
doaj   +1 more source

Sub-telomeric core X and Y' elements in S. cerevisiae suppress extreme variations in gene silencing. [PDF]

PLoS ONE, 2011
Telomere Position Effect (TPE) is governed by strong repression signals emitted by telomeres via the Sir2/3/4 Histone Deacetylase complex. These signals are then relayed by weak proto-silencers residing in the subtelomeric core X and Y' elements ...
Patricia Power, Daniel Jeffery, Muhammad Attiq Rehman, Arjun Chatterji, Krassimir Yankulov   +4 more
doaj   +1 more source