Results 21 to 30 of about 42,139 (259)
Sub-telomeric core X and Y' elements in S. cerevisiae suppress extreme variations in gene silencing. [PDF]
PLoS ONE, 2011 Telomere Position Effect (TPE) is governed by strong repression signals emitted by telomeres via the Sir2/3/4 Histone Deacetylase complex. These signals are then relayed by weak proto-silencers residing in the subtelomeric core X and Y' elements ...
Patricia Power +4 more
doaj +1 more source
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Frontiers in Physiology, 2023 Skeletal muscles, the largest organ responsible for energy metabolism in most mammals, play a vital role in maintaining the body’s homeostasis.
Junjie Xu, Chenglong Li, Xiaolong Kang
doaj +1 more source
Journal of Translational Medicine, 2023 NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT).
Siyi Lu +3 more
doaj +1 more source
Histone Acetyltransferases and Stem Cell Identity [PDF]
Cancers, 2021 Acetylation of histones is a key epigenetic modification involved in transcriptional regulation. The addition of acetyl groups to histone tails generally reduces histone-DNA interactions in the nucleosome leading to increased accessibility for transcription factors and core transcriptional machinery to bind their target sequences.
Ruicen He, Arthur Dantas, Karl Riabowol
openaire +2 more sources
MOF Regulates TNK2 Transcription Expression to Promote Cell Proliferation in Thyroid Cancer
Frontiers in Pharmacology, 2020 MOF is a well-known histone acetyltransferase to catalyze acetylation of histone H4 lysine 16 (K16), and it is relevant to diverse biological processes, such as gene transcription, cell cycle, early embryonic development and tumorigenesis.
Danyang Li +10 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2023 Covalent modifications of chromatin regulate genomic structure and accessibility in diverse biological processes such as transcriptional regulation, cell cycle progression, and DNA damage repair.
Qihao Liu +2 more
doaj +1 more source
Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals [PDF]
BioEssays, 2018 Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair. Histone acetyltransferases were initially identified as co‐activators that link DNA‐binding transcription factors to the general ...
Voss, AK, Thomas, T
openaire +3 more sources
Communications Biology, 2021 Yang et al find that phase separation of the Epstein-Barr virus nuclear antigen 2 (EBNA2) is involved in the formation of accessible chromatin domains of the host genome.
Yiting Yang +12 more
doaj +1 more source