The Histone Acetyltransferase CgHat1 Regulates Growth, Development, and Pathogenicity of Colletotrichum gloeosporioides [PDF]
Journal of FungiColletotrichum gloeosporioides causes anthracnose on a wide range of plants, resulting in serious economic losses worldwide. However, the molecular mechanisms underlying its pathogenicity still remain largely unknown. In the past 20 years, the importance
Binghong Jia +7 more
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Histone acetyltransferase Gcn5-mediated histone H3 acetylation facilitates cryptococcal morphogenesis and sexual reproduction [PDF]
mSphere, 2023 Sexual reproduction is the primary driving force behind eukaryotic environmental adaptation and evolution. In the human fungal pathogen Cryptococcus neoformans, sexual reproduction plays a critical role in the emergence of highly virulent strains and ...
Man Chen +9 more
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Genome-wide identification and expression analysis of histone deacetylase and histone acetyltransferase genes in response to drought in poplars [PDF]
BMC GenomicsBackground Histone deacetylases (HDACs) and histone acetyltransferases (HATs) are involved in plant growth and development as well as in response to environmental changes, by dynamically regulating gene acetylation levels.
Huanhuan Li +4 more
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Gcn5 histone acetyltransferase is present in the mitoplasts
Biology Open, 2019 In Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines.
Arianna Montanari +4 more
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Structure of the NuA4 histone acetyltransferase complex [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Roger D Kornberg, Heqiao Zhang
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Latest Research Development in Histone Acetylation in the Pathogenesis of Asthma [PDF]
Zhongguo quanke yixue, 2022 Asthma is primarily marked by airway hyperresponsiveness, inflammation, and remodeling. Histone acetylation is one of the most common epigenetic modifications that regulates histone acetyltransferase and histone deacetylase, and imbalanced regulation may
CHEN Shaopeng, ZENG Minjuan, LAI Tianwen
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HAT1: Landscape of Biological Function and Role in Cancer
Cells, 2023 Histone modifications, as key chromatin regulators, play a pivotal role in the pathogenesis of several diseases, such as cancer. Acetylation, and more specifically lysine acetylation, is a reversible epigenetic process with a fundamental role in cell ...
Vincenza Capone +6 more
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The BRCA2 is a histone acetyltransferase [PDF]
Oncogene, 1998 Patients carrying mutations in BRCA1 or BRCA2 tumor suppressor genes have shown to have high risk in developing breast and ovarian cancers. Two potential functions of BRCA2 were proposed which includes role in the regulation of transcription and also in DNA repair.
H, Siddique +3 more
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Enhancer of Acetyltransferase Chameau (EAChm) Is a Novel Transcriptional Co-Activator. [PDF]
PLoS ONE, 2015 Acetylation of nucleosomal histones by diverse histone acetyltransferases (HAT) plays pivotal roles in many cellular events. Discoveries of novel HATs and HAT related factors have provided new insights to understand the roles and mechanisms of histone ...
Takeya Nakagawa +6 more
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Quiescent and proliferative fibroblasts exhibit differential p300 HAT activation through control of 5-methoxytryptophan production. [PDF]
PLoS ONE, 2014 Quiescent fibroblasts possess unique genetic program and exhibit high metabolic activity distinct from proliferative fibroblasts. In response to inflammatory stimulation, quiescent fibroblasts are more active in expressing cyclooxygenase-2 and other ...
Huei-Hsuan Cheng +5 more
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