Results 11 to 20 of about 73,046 (329)
Journal of Big Data, 2022 Dynamic changes in epigenetic landscape reflect a critical command of lineage-specific gene expression. In an effort to discern the epigenetic regulatory networks of myogenic differentiation, we have used systematic and integrative approaches to explore ...
Yuan Li +4 more
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Frontiers in Cell and Developmental Biology, 2023 Acetylation of lysine residues on histone tails is an important post-translational modification (PTM) that regulates chromatin dynamics to allow gene transcription as well as DNA replication and repair.
Tiina Viita, Jacques Côté
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Histone Acetyltransferases and Stem Cell Identity [PDF]
Cancers, 2021 Acetylation of histones is a key epigenetic modification involved in transcriptional regulation. The addition of acetyl groups to histone tails generally reduces histone-DNA interactions in the nucleosome leading to increased accessibility for transcription factors and core transcriptional machinery to bind their target sequences.
Ruicen He, Arthur Dantas, Karl Riabowol
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BMC Biology, 2007 Background Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 ...
Greenblatt Jack F +7 more
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Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells [PDF]
, 2016 Cancer stem cells (CSCs) play an important role in tumor initiation, progression, therapeutic failure and tumor relapse. In this study, we evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4’-chlorophenyl)thiazol-2-yl ...
Buglioni, Simonetta +14 more
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Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4. [PDF]
PLoS Genetics, 2013 Histone acetyltransferase 1 is an evolutionarily conserved type B histone acetyltransferase that is thought to be responsible for the diacetylation of newly synthesized histone H4 on lysines 5 and 12 during chromatin assembly.
Prabakaran Nagarajan +9 more
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Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]
, 2016 AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano +3 more
core +2 more sources
Frontiers in Plant Science, 2017 The epigenetic modulatory SAGA complex is involved in various developmental and stress responsive pathways in plants. Alternative transcripts of the SAGA complex's enzymatic subunit GCN5 have been identified in Brachypodium distachyon.
Alexandre Martel +3 more
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Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms
eLife, 2020 Histone acetylation and deposition of H2A.Z variant are integral aspects of active transcription. In Drosophila, the single DOMINO chromatin regulator complex is thought to combine both activities via an unknown mechanism.
Alessandro Scacchetti +8 more
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Sub-telomeric core X and Y' elements in S. cerevisiae suppress extreme variations in gene silencing. [PDF]
PLoS ONE, 2011 Telomere Position Effect (TPE) is governed by strong repression signals emitted by telomeres via the Sir2/3/4 Histone Deacetylase complex. These signals are then relayed by weak proto-silencers residing in the subtelomeric core X and Y' elements ...
Patricia Power +4 more
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