Results 71 to 80 of about 391,128 (337)
MYST4 (MYST histone acetyltransferase (monocytic leukemia) 4) [PDF]
, 2006 Review on MYST4 (MYST histone acetyltransferase (monocytic leukemia) 4), with data on DNA, on the protein encoded, and where the gene is ...
Vizmanos, JL
core +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions
Nature CommunicationsInterleukin-1α is a suggested dual-function cytokine that diverged from interleukin-1β in mammals potentially by acquiring additional biological roles that relate to highly conserved regions in the pro-domain of interleukin-1α, including a nuclear ...
Rose Wellens +11 more
doaj +1 more source
BRD4 is a Histone Acetyltransferase that Evicts Nucleosomes from Chromatin
Nature Structural &Molecular Biology, 2016 Bromodomain protein 4 (BRD4) is a chromatin-binding protein implicated in cancer and autoimmune diseases that functions as a scaffold for transcription factors at promoters and super-enhancers.
B. N. Devaiah +8 more
semanticscholar +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Cells, 2021 Cardiovascular disease is the leading cause of accelerated as well as chronological aging-related human morbidity and mortality worldwide. Genetic, immunologic, unhealthy lifestyles including daily consumption of high-carb/high-fat fast food, lack of ...
Asish K. Ghosh
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Beyond Wolbachia—Can a small molecule control insect reproduction?
Cell ReportsKaur et al.1 demonstrate reduced histone acetylation as a key mechanism underpinning Wolbachia’s paternal-effect embryonic lethality trait in Drosophila melanogaster.
Robson Kriiger Loterio +1 more
doaj +1 more source
Microbiology Spectrum, 2023 The histone acetyltransferase (HAT) Gcn5 ortholog is essential for a variety of fungi. Here, we characterize the roles of Ada2 and Ada3, which are functionally linked to Gcn5, in the insect-pathogenic fungus Beauveria bassiana.
Shun-Juan Hu +10 more
doaj +1 more source
Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer
Stem Cells International, 2018 Protein acetylation is one of the most important posttranslational modifications catalyzed by acetyltransferases and deacetylases, through the addition and removal of acetyl groups to lysine residues. Lysine acetylation can affect protein-nucleic acid or
D. Trisciuoglio +2 more
semanticscholar +1 more source