Results 51 to 60 of about 421 (119)
Chz1, a Nuclear Chaperone for Histone H2AZ [PDF]
Molecular Cell, 2007 The histone variant H2AZ marks nucleosomes flanking the promoters of most genes of budding yeast. The incorporation of H2AZ into chromatin is dependent on the SWR1 complex, which catalyses the replacement of conventional histone H2A with H2AZ. In cells, the pool of unincorporated histone H2AZ has previously been found in association with Nap1, a ...
Luk, Ed +10 more
openaire +2 more sources
Nature CommunicationsChromatin condensation is dynamically regulated throughout the cell cycle and plays key roles in modulating gene accessibility. The DNA-histone dynamics in the nucleosome are central to the regulation mechanisms of chromatin condensation, which remain ...
Jia Gao +4 more
doaj +1 more source
Nucleosome thermodynamics, histone modifications, and histone chaperone function
The FASEB Journal, 2010 Genome accessibility is regulated to a large part by the posttranslational modification of histones (PTM). Surprisingly, and despite the fact that nucleosomes were first characterized over 35 years ago, very little is known about the free energy required to assemble and maintain ...
Karolin Luger +4 more
openaire +1 more source
Regulation of replicative histone RNA metabolism by the histone chaperone ASF1
Molecular Cell, 2022 SUMMARYIn S phase, duplication and assembly of the whole genome into chromatin requires upregulation of replicative histone gene expression. Here, we explored a potential role of histone chaperones in this process thereby linking chromatin assembly with histone production in human cells.
Mendiratta, Shweta +6 more
openaire +3 more sources
A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover. [PDF]
PLoS Genetics, 2011 Dynamic modification of histone proteins plays a key role in regulating gene expression. However, histones themselves can also be dynamic, which potentially affects the stability of histone modifications.
Kitty F Verzijlbergen +7 more
doaj +1 more source
Erratum: Histone chaperones: an escort network regulating histone traffic [PDF]
Nature Structural & Molecular Biology, 2007 Nat. Struct. Mol. Biol. 14, 997–1007 (2007); published online 5 November 2007; corrected after print 5 November 2007 In the print version of this article, the reference to the Review by Shilatifard and co-workers is incorrect. On page 1002, it should be referred to as 'Bhaumik et al.68' and on page 1006, the reference citation should read:
Leanne De Koning +3 more
openaire +1 more source
Histone chaperone regulates replication
The Journal of Cell Biology, 2008 Histone supply and demand are tightly coupled at the replication fork by a chaperone, according to Genevieve Almouzni (Curie Institute, Paris, France) and colleagues. The chaperone, Asf1, passes histones from parental to daughter DNA strands and unwinds just enough DNA to match its transfer activities.
openaire +2 more sources
Nature Communications, 2023 Here the authors investigated the direct collaboration between ubiquitinated histone H2B (ubH2B) with FACT at the nucleosome level. They found ubH2B enhances FACT’s chaperone property, recruits FACT to form a stable altered nucleosome state, and provides
Anfeng Luo +10 more
doaj +1 more source
UBR7 acts as a histone chaperone for post‐nucleosomal histone H3
The EMBO Journal, 2021 Histone chaperones modulate the stability of histones beginning from histone synthesis, through incorporation into DNA, and during recycling during transcription and replication. Following histone removal from DNA, chaperones regulate histone storage and degradation.
Ann K Hogan +16 more
openaire +2 more sources
In vivo Study of the Histone Chaperone Activity of Nucleolin by FRAP
Biochemistry Research International, 2011 Nucleolin is a major nucleolar protein involved in various aspects of ribosome biogenesis such as regulation of polymerase I transcription, pre-RNA maturation, and ribosome assembly.
Xavier Gaume +4 more
doaj +1 more source