Results 201 to 210 of about 17,972 (261)

Obesity‐ and Glucose‐Dependent Differential Autophagy Marker Expression in Adipose Tissues and Adipocytes

Obesity Science &Practice, Volume 12, Issue 3, June 2026.
ABSTRACT Background Autophagy is an evolutionarily highly conserved process and plays an important role in cellular homeostasis and metabolism. In obesity and obesity‐associated insulin resistance, both enhanced and suppressed autophagy have been observed in adipose tissues (AT).
Edita Islami, Andreas Schmid, Daniel Steger, Sebastian Köhler, Andreas Schäffler, Thomas Karrasch   +5 more
wiley   +1 more source

Blm10/PA200‐Activated 20S Proteasomes Promote α‐Synuclein Degradation and Bypass Proteasome Inhibition in Parkinson's Disease Models

Aging Cell, Volume 25, Issue 6, June 2026.
This study demonstrates that α‐synuclein expression stabilizes the proteasome activator Blm10, thereby linking α‐synuclein stress to changes in proteasome composition. Blm10/PA200‐capped 20S proteasomes efficiently degrade both monomeric and oligomeric α‐synuclein and remain resistant to α‐synuclein‐induced inhibition.
Tariq T. Ali, Anton Zhornyak, Madiha Merghani, Zora Buschenlange, Eri Sakata, Tiago F. Outeiro, Blagovesta Popova, Gerhard H. Braus   +7 more
wiley   +1 more source

The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations. [PDF]

Mol Cell, 2015
Jeronimo C, Watanabe S, Kaplan CD, Peterson CL, Robert F.   +4 more
europepmc   +1 more source

Oxidative Stress and Diminished Mitochondrial Proteostatic Reserve Are Linked to Enhanced mtUPR Initiation in Aged Mouse Muscle

Aging Cell, Volume 25, Issue 6, June 2026.
Aged mouse skeletal muscle exhibits greater mtUPR transcriptional initiation following repeated physical stress than young mice, coinciding with reduced mitochondrial proteostatic reserve and heightened oxidative burden. We implicate a mtROS‐JNK‐CHOP axis as a contributor to the enhanced response.
Grant R. Laskin, Baylah R. Mazonson, LaDora V. Thompson   +2 more
wiley   +1 more source

Dissecting the Molecular Roles of Histone Chaperones in Histone Acetylation by Type B Histone Acetyltransferases (HAT-B). [PDF]

J Biol Chem, 2015
Haigney A, Ricketts MD, Marmorstein R.
europepmc   +1 more source

Internalized Evolutionary Inertia on Body Plan Evolution

Evolution &Development, Volume 28, Issue 2, June 2026.
Animal development appears to intrinsically bias phenotypic evolution, though the exact mechanism is unclear. This review discusses potential mechanisms by which animal embryogenesis limits phenotypic diversification and considers whether inherent evolutionary inertia could allow us to predict future evolutionary paths.
Wenxin Zeng, Naoki Irie
wiley   +1 more source

Eviction of linker histone H1 by NAP-family histone chaperones enhances activated transcription. [PDF]

Epigenetics Chromatin, 2015
Zhang Q, Giebler HA, Isaacson MK, Nyborg JK.   +3 more
europepmc   +1 more source

Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP‐43 Proteinopathy

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
TDP‐43 pathology is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Peptidyl‐prolyl cis–trans isomerase A (PPIA), a foldase and chaperone protein, modulates TDP‐43 function in an acetylation‐dependent manner. Here, we show that inhibition of lysine deacetylation with vorinostat (SAHA) increases PPIA acetylation and ...
Serena Scozzari, Stefano Fabrizio Columbro, Monica Favagrossa, Massimo Tortarolo, Alfredo Cagnotto, Mario Salmona, Giovanni De Marco, Caterina Bendotti, Andrea Calvo, Laura Pasetto, Valentina Bonetto   +10 more
wiley   +1 more source

The aging paradox of Cushing's syndrome: Stress without clear senescence?

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Cushing's syndrome (CS), characterized by chronic endogenous hypercortisolism and disruption of the normal circadian cortisol rhythm, represents a unique human model for investigating the interplay between stress endocrinology and biological aging.
Israel Nunes Silveira, Alexandro Guterres   +1 more
wiley   +1 more source

Hydrogen Gas Enhances Salinity Tolerance in Tomato Seedlings by Regulating the S‐Nitrosylation of MEK1

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3656-3678, June 2026.
ABSTRACT Hydrogen gas (H2) effectively alleviates abiotic stress in horticultural plants. Protein S‐nitrosylation, a key post‐translational modification, serves as a critical mechanism for nitric oxide (NO) to exert its biological function under adverse conditions.
Hua Fang, Xuetong Wu, Dengjing Huang, Xinfang Chen, Zhiya Liu, Xuejuan Pan, Huan Chen, Dandan Zheng, Caicai Ma, Xuemei Hou, Shuya Wang, Chunlei Wang, Weibiao Liao   +12 more
wiley   +1 more source